S35B2_DROME
ID S35B2_DROME Reviewed; 465 AA.
AC Q9VEI3; Q960E7;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 1;
DE AltName: Full=PAPS transporter 1;
DE AltName: Full=Protein slalom;
GN Name=sll; Synonyms=PAPST1; ORFNames=CG7623;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, AND
RP SUBCELLULAR LOCATION.
RX PubMed=12716889; DOI=10.1074/jbc.m302439200;
RA Kamiyama S., Suda T., Ueda R., Suzuki M., Okubo R., Kikuchi N., Chiba Y.,
RA Goto S., Toyoda H., Saigo K., Watanabe M., Narimatsu H., Jigami Y.,
RA Nishihara S.;
RT "Molecular cloning and identification of 3'-phosphoadenosine 5'-
RT phosphosulfate transporter.";
RL J. Biol. Chem. 278:25958-25963(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=12853478; DOI=10.1093/emboj/cdg345;
RA Lueders F., Segawa H., Stein D., Selva E.M., Perrimon N., Turco S.J.,
RA Haecker U.;
RT "Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter
RT essential for development in Drosophila.";
RL EMBO J. 22:3635-3644(2003).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi.
CC Required for the dorsoventral patterning, suggesting that it mediates
CC the transport of the sulfate donor required for the sulfotransferase
CC activity of pip (pipe). {ECO:0000269|PubMed:12716889,
CC ECO:0000269|PubMed:12853478}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=1.2 uM for PAPS {ECO:0000269|PubMed:12716889};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed throughout embryogenesis. During
CC oogenesis, it is expressed strongly in the nurse cells of the germline.
CC Maternally expressed at the syncytial blastoderm stage. Zygotically
CC expressed, from after germ-band elongation in the invaginating salivary
CC gland placodes. Remains expressed predominantly in this tissue
CC throughout embryogenesis, but low-level expression may also be present
CC throughout the embryo. {ECO:0000269|PubMed:12853478}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:12853478}.
CC -!- DISRUPTION PHENOTYPE: Flies display defects in wingless (wg) and
CC hedgehog (hh) signaling, probably due to the lack of sulfation of
CC glycosaminoglycans by sulfotransferases such as sfl.
CC {ECO:0000269|PubMed:12853478}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
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DR EMBL; AB107958; BAC79118.1; -; mRNA.
DR EMBL; AE014297; AAF55438.1; -; Genomic_DNA.
DR EMBL; AY052098; AAK93522.1; -; mRNA.
DR RefSeq; NP_001247153.1; NM_001260224.2.
DR RefSeq; NP_524389.1; NM_079665.4.
DR AlphaFoldDB; Q9VEI3; -.
DR BioGRID; 67147; 4.
DR IntAct; Q9VEI3; 7.
DR STRING; 7227.FBpp0082903; -.
DR TCDB; 2.A.7.11.2; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q9VEI3; -.
DR DNASU; 42115; -.
DR EnsemblMetazoa; FBtr0083462; FBpp0082903; FBgn0038524.
DR EnsemblMetazoa; FBtr0305308; FBpp0293851; FBgn0038524.
DR GeneID; 42115; -.
DR KEGG; dme:Dmel_CG7623; -.
DR UCSC; CG7623-RA; d. melanogaster.
DR CTD; 42115; -.
DR FlyBase; FBgn0038524; sll.
DR VEuPathDB; VectorBase:FBgn0038524; -.
DR eggNOG; KOG1581; Eukaryota.
DR GeneTree; ENSGT00940000157927; -.
DR HOGENOM; CLU_036019_3_1_1; -.
DR InParanoid; Q9VEI3; -.
DR OMA; CGAIGQV; -.
DR OrthoDB; 820879at2759; -.
DR PhylomeDB; Q9VEI3; -.
DR Reactome; R-DME-174362; Transport and synthesis of PAPS.
DR Reactome; R-DME-727802; Transport of nucleotide sugars.
DR SABIO-RK; Q9VEI3; -.
DR BioGRID-ORCS; 42115; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42115; -.
DR PRO; PR:Q9VEI3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038524; Expressed in cleaving embryo and 23 other tissues.
DR ExpressionAtlas; Q9VEI3; baseline and differential.
DR Genevisible; Q9VEI3; DM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; IDA:UniProtKB.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IMP:FlyBase.
DR GO; GO:0007310; P:oocyte dorsal/ventral axis specification; IMP:FlyBase.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..465
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 1"
FT /id="PRO_0000213378"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 22
FT /note="T -> S (in Ref. 4; AAK93522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 465 AA; 52282 MW; 5B9CA45AB2BBA7C7 CRC64;
MYAYNKMGRV PELVICSFIV VTLLVIHFFS DLLRASLGGY YNQDVTLSQL VESQNSDYAW
FLKLLVNCFG YSCVFVPGFL IYKYVGRINY LERGNKTFLH KAINMCITGN SGYDQLDAGT
STADKDRPAA STAPKRTSSQ EAVQLLWCFG GLMISYLTWG VLQEKIMTQN YLNFTGESAK
FKDSQFLVFS NRLLAFLVAL AYLQWQPSPV RHRAPLYKYS YASFSNIMSA WFQYEALKFV
NFPTQVLAKS CKIIPVMLMG KIMSKAKYES YEYVTALLIS LGMIFFMSGS SDSSKASGVT
TLTGIFLLSM YMVFDSFTAN WQGSLFKSYG MTPLQMMCGV NLFSSIFTGA SLSMQGGFMD
SLAFATEHPK FVFDMVVLSV CSAVGQLFIY HTIDVFGPVV FTIIMTLRQA VAIMLSCFIY
QHSISLLGIF GVLIVFVAIF LRVYCTQRLR AIRKRAEANK PKMAV