S35B3_AEDAE
ID S35B3_AEDAE Reviewed; 382 AA.
AC Q17CE7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 2;
DE AltName: Full=PAPS transporter 2;
DE AltName: Full=Solute carrier family 35 member B3 homolog;
GN Name=Papst2 {ECO:0000250|UniProtKB:Q9VVD9}; ORFNames=AAEL004594;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT44004.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi.
CC Essential for viability. Involved in glycosaminoglycan synthesis and
CC the subsequent signaling. May be involved in hh and dpp signaling by
CC controlling the sulfation of heparan sulfate (HS) (By similarity).
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9VVD9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000255}.
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DR EMBL; CH477309; EAT44004.1; -; Genomic_DNA.
DR RefSeq; XP_001649448.1; XM_001649398.1.
DR AlphaFoldDB; Q17CE7; -.
DR SMR; Q17CE7; -.
DR STRING; 7159.AAEL004594-PA; -.
DR eggNOG; KOG1582; Eukaryota.
DR HOGENOM; CLU_036019_2_0_1; -.
DR InParanoid; Q17CE7; -.
DR OMA; QFGYYIG; -.
DR PhylomeDB; Q17CE7; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; ISS:UniProtKB.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Developmental protein; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..382
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 2"
FT /id="PRO_0000307350"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 42557 MW; FE89A24C9DB4DAE1 CRC64;
MSVSNRNGNG SEVIYVGDRS TNRPPRNAPS PDEDRKEVKI LFFDLTYYNT TTKFLLCCAG
VFVLYLLYGY MQELIFTLDG FKPYGWFLTL VQFAYYTVFG YVERSLESKR VPRCIPMKTY
VLLAFLTLGT MGLSNSSLGY LNYPTQVIFK CCKLVPVLIG SILIQGKKHG PLDFLAAIAM
CLGLTLFTLA DSQVSPNFNP FGVLLISLAL LCDAAIGNVQ EKAMREHKAP NNEVVIYSYG
IGFVYLSVIM LLTGNLFSGI TFCMKYPVET FGYAFLFSLS GYLGIQIVLT LVRTCGAPLA
ATVTTARKAV TIALSFVFFS KPFTINYLWS GLIVVLGIYL NVYSKRSKLT FADLNRTAER
IYRKLVPQRG GSSSTKKLLL EV
