S35B3_ANOGA
ID S35B3_ANOGA Reviewed; 377 AA.
AC Q7Q5D4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 2;
DE AltName: Full=PAPS transporter 2;
DE AltName: Full=Solute carrier family 35 member B3 homolog;
GN Name=Papst2 {ECO:0000250|UniProtKB:Q9VVD9}; ORFNames=AGAP006509;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi.
CC Essential for viability. Involved in glycosaminoglycan synthesis and
CC the subsequent signaling. May be involved in hh and dpp signaling by
CC controlling the sulfation of heparan sulfate (HS) (By similarity).
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9VVD9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000255}.
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DR EMBL; AAAB01008960; EAA11308.4; -; Genomic_DNA.
DR RefSeq; XP_316536.4; XM_316536.4.
DR AlphaFoldDB; Q7Q5D4; -.
DR SMR; Q7Q5D4; -.
DR STRING; 7165.AGAP006509-PA; -.
DR PaxDb; Q7Q5D4; -.
DR GeneID; 1277103; -.
DR KEGG; aga:AgaP_AGAP006509; -.
DR CTD; 1277103; -.
DR VEuPathDB; VectorBase:AGAP006509; -.
DR eggNOG; KOG1582; Eukaryota.
DR HOGENOM; CLU_036019_2_0_1; -.
DR InParanoid; Q7Q5D4; -.
DR OMA; QFGYYIG; -.
DR OrthoDB; 1116466at2759; -.
DR PhylomeDB; Q7Q5D4; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; ISS:UniProtKB.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Developmental protein; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..377
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 2"
FT /id="PRO_0000307351"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 377 AA; 42335 MW; CC999BACC479C692 CRC64;
MAGAKSEVIY LGDKDLNRNR HRDRDQSPER EIKILFFDLT HYNRTTQFLL CCGGVFALYL
VYGYMQELIF TLEGFRPYGW YLTLVQFAYY TAFGYIERSV ERTTVPRCIP LRTYALLAFL
TLGTMGLSNS SVGYLNYPTQ VIFKCCKLIP VLIGSVLIQG KKHGPMDFFA ATAMCLGLIL
FTLADSQVQP DFNRFGVFLI SLALLCDAAI GNVQEKAMRE HRAPNNEVVI YSYGIGFVYL
AVIMLLSGHL VQGVAFCARY PMETYGYAFL FSLTGYLGIQ IVLTLVRTCG APLAATVTTA
RKAVTIALSF VFFSKPFTIQ YLWSGLIVVF GIYLNVYSKR SKLTFADLGR MASTVYRWVL
RLPPAKDGGS RTSLLEV
