S35B3_CAEEL
ID S35B3_CAEEL Reviewed; 364 AA.
AC Q20787; Q1W0S3;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 2;
DE AltName: Full=Adenosine 3'-phosphate 5'-phosphosulfate transporter;
DE AltName: Full=PAPS transporter 2;
DE AltName: Full=Solute carrier family 35 member B3 homolog;
GN Name=pst-2; ORFNames=F54E7.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q20787-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20787-2; Sequence=VSP_028734;
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
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DR EMBL; FO080172; CCD61761.1; -; Genomic_DNA.
DR EMBL; FO080172; CCD61762.1; -; Genomic_DNA.
DR PIR; T34304; T34304.
DR RefSeq; NP_001040855.1; NM_001047390.3. [Q20787-1]
DR RefSeq; NP_001040856.1; NM_001047391.2. [Q20787-2]
DR AlphaFoldDB; Q20787; -.
DR SMR; Q20787; -.
DR STRING; 6239.F54E7.1a; -.
DR EPD; Q20787; -.
DR PaxDb; Q20787; -.
DR EnsemblMetazoa; F54E7.1a.1; F54E7.1a.1; WBGene00018827. [Q20787-1]
DR EnsemblMetazoa; F54E7.1b.1; F54E7.1b.1; WBGene00018827. [Q20787-2]
DR GeneID; 175787; -.
DR KEGG; cel:CELE_F54E7.1; -.
DR UCSC; F54E7.1a; c. elegans. [Q20787-1]
DR CTD; 175787; -.
DR WormBase; F54E7.1a; CE01312; WBGene00018827; pst-2. [Q20787-1]
DR WormBase; F54E7.1b; CE40069; WBGene00018827; pst-2. [Q20787-2]
DR eggNOG; KOG1582; Eukaryota.
DR GeneTree; ENSGT00940000157040; -.
DR HOGENOM; CLU_036019_2_0_1; -.
DR InParanoid; Q20787; -.
DR OMA; QFGYYIG; -.
DR OrthoDB; 1116466at2759; -.
DR PhylomeDB; Q20787; -.
DR Reactome; R-CEL-174362; Transport and synthesis of PAPS.
DR Reactome; R-CEL-727802; Transport of nucleotide sugars.
DR PRO; PR:Q20787; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00018827; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IDA:WormBase.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:WormBase.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; IDA:WormBase.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; IDA:WormBase.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..364
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 2"
FT /id="PRO_0000213383"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 2..118
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_028734"
SQ SEQUENCE 364 AA; 40836 MW; C455622EAF486FFC CRC64;
MTAAQIHSDC SVHMLPRHVK EDVEPIHLLG FNIARKPKWL QFVLLSLAIF ILYIGYGYMQ
ELIFKLPGMK PFGWTLTLIQ FLIYSGCGYT ECIIWHNTKR MIPWRIYGVI AFFTVATMGL
SNASVGYLNY PTQVIFKCCK LIPVLIGGIL IQGKRYGWID IGAAMLMSLG IIMFTLADNK
VSPNFDSRGY IMICGALLAD AVIGNIQEKN MKKYGGSSNE MVLYSYGIGS VFIFAFVVLS
GEVFSAIPFF LENSWKTFGY ALILSCLGYL GVNVVLTHIK VFGALVAVTV TTLRKALTII
LSFMLFSKPF TIEYVYAGSV VMLAIYLNLY SKNKTSWDNM IRRFVARAMG YHDVSVARKD
PMTV
