S35B3_DROPS
ID S35B3_DROPS Reviewed; 392 AA.
AC Q29EY2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Adenosine 3'-phospho 5'-phosphosulfate transporter 2;
DE AltName: Full=PAPS transporter 2;
DE AltName: Full=Solute carrier family 35 member B3 homolog;
GN Name=Papst2 {ECO:0000250|UniProtKB:Q9VVD9}; ORFNames=GA20635;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Mediates the transport of adenosine 3'-phospho 5'-
CC phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal
CC sulfuryl donor for sulfation events that take place in the Golgi.
CC Essential for viability. Involved in glycosaminoglycan synthesis and
CC the subsequent signaling. May be involved in hh and dpp signaling by
CC controlling the sulfation of heparan sulfate (HS) (By similarity).
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9VVD9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9VVD9}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH379070; EAL29927.2; -; Genomic_DNA.
DR RefSeq; XP_001352431.2; XM_001352395.3.
DR RefSeq; XP_015043560.1; XM_015188074.1.
DR AlphaFoldDB; Q29EY2; -.
DR SMR; Q29EY2; -.
DR STRING; 7237.FBpp0286550; -.
DR EnsemblMetazoa; FBtr0288112; FBpp0286550; FBgn0080629.
DR EnsemblMetazoa; FBtr0365693; FBpp0328990; FBgn0080629.
DR GeneID; 4811890; -.
DR KEGG; dpo:Dpse_GA20635; -.
DR eggNOG; KOG1582; Eukaryota.
DR HOGENOM; CLU_036019_2_0_1; -.
DR InParanoid; Q29EY2; -.
DR OMA; QFGYYIG; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0080629; Expressed in male reproductive system and 2 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0000137; C:Golgi cis cisterna; IEA:EnsemblMetazoa.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046964; F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0046963; P:3'-phosphoadenosine 5'-phosphosulfate transport; ISS:UniProtKB.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:EnsemblMetazoa.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Developmental protein; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..392
FT /note="Adenosine 3'-phospho 5'-phosphosulfate transporter
FT 2"
FT /id="PRO_0000307352"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 11..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 43235 MW; C63851ED16234677 CRC64;
MGDGQAGSVI NINGSASGQQ APTSNSPTLT RKSSSSELPP ELRILCFDLT HYNQTTQFLL
SCAGVFILYI LYGYLQELIF TVEGFKPFGW FLTLVQFGYY IGFGLVERRL EAYRSGRRSL
WNVEPAPRCI PMKTYLVLAA LTLGTMGLSN SSLGYLNYPT QVIFKCCKLI PVLVGSILIQ
GKRYGPLDFA AASCMCIGLA WFTLADSQMT PNFNLLGVAM ISGALLCDAA IGNVQEKAMK
EHKAPSSEVV FYSYGLGFVY LFVIMLVTGN FFSGFAFCLE HPLQTFGYGF LFSLSGYLGI
QFVLALVRSS GAPIAATVTT ARKAVTIAFS FVLFSKPFTV QYLWSGLIVV LGIYLNVYSK
KNKLTFADIR SRFKQFGFRL ARSPSRKFLV EV
