ID   S35B4_DANRE             Reviewed;         331 AA.
AC   Q7ZW46;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Solute carrier family 35 member B4;
GN   Name=slc35b4; ORFNames=zgc:55288;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC       UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from
CC       cytosol into Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC045293; AAH45293.1; -; mRNA.
DR   AlphaFoldDB; Q7ZW46; -.
DR   SMR; Q7ZW46; -.
DR   STRING; 7955.ENSDARP00000095658; -.
DR   PaxDb; Q7ZW46; -.
DR   ZFIN; ZDB-GENE-030131-2457; slc35b4.
DR   eggNOG; KOG1583; Eukaryota.
DR   InParanoid; Q7ZW46; -.
DR   PhylomeDB; Q7ZW46; -.
DR   Reactome; R-DRE-727802; Transport of nucleotide sugars.
DR   PRO; PR:Q7ZW46; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005464; F:UDP-xylose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="UDP-xylose and UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213389"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  37221 MW;  0BD931C194132173 CRC64;
     MNTLFAVTLV FVGCCSNVVF LELLVRDFPG CGNIVTFAQF AFIALEGFIF ETNFGRKKPQ
     IPLSNYVIMV TMFFTVSVIN NYALDFNIAM PLHMIFRSGS LIANMILGII ILKNRYSMSK
     YLSIVLVSVG IFICTIMSAK QVNVEKGGTE EDGVYAFMHW LLGIAMLTFA LLMSARMGIF
     QETLYKKYGK HSKEALFYNH CLPLPGFLLL STNIYNHAVL FSQSPPMEVP VIGLSMPVMW
     FYLLMNVITQ YVCIRGVFIL TTECASLTVT LVVTLRKFLS LIISILYFQN PFTAWHWVGT
     AVVFLGTLLY TEVLSSIPAA FKGYKVDKKA E