S35B4_DICDI
ID S35B4_DICDI Reviewed; 351 AA.
AC Q869W7; Q554D3;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 2.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=UDP-N-acetylglucosamine transporter slc35b4;
DE AltName: Full=Solute carrier family 35 member B4;
GN Name=slc35b4; ORFNames=DDB_G0275061;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL69811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000013; EAL69811.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_643778.1; XM_638686.1.
DR AlphaFoldDB; Q869W7; -.
DR SMR; Q869W7; -.
DR STRING; 44689.DDB0167452; -.
DR TCDB; 2.A.7.10.3; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q869W7; -.
DR EnsemblProtists; EAL69811; EAL69811; DDB_G0275061.
DR GeneID; 8619823; -.
DR KEGG; ddi:DDB_G0275061; -.
DR dictyBase; DDB_G0275061; slc35b4.
DR eggNOG; KOG1583; Eukaryota.
DR InParanoid; Q869W7; -.
DR PhylomeDB; Q869W7; -.
DR Reactome; R-DDI-727802; Transport of nucleotide sugars.
DR PRO; PR:Q869W7; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..351
FT /note="UDP-N-acetylglucosamine transporter slc35b4"
FT /id="PRO_0000330913"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 40145 MW; AC200274F943B887 CRC64;
MIFDSLISLI PISMIMVGCC SNVISLELIM KQSQSHAILV TFFQFATVAF ISFFVNIRWK
QVFSIFWIPI GLRERKIPLK TYFLMVSIFF ILSVLNNKAL DCDIPIPFHM IFRSSSLLST
IVIGSIFYRK SYSKQQILSL IMVTLGIIFA TFSSMPDSKK EISLGHEPNL LRFSIGMLML
IAAMFLSSIL GLIQEHTYKL YGKDRHYETI FYSHLFSLPF FLLFKDDILH HIQLNNDSAL
MALPFGFGSF PTLWVYLIVN VLTQYVCIQG VFILTGKTST LTCTLVISIR KFLSIIISVI
YFNNHFTSLL FTGTILVFLG TFMYSTSGKV IEKPLPPTKQ VKEIEKEKKL N
