ABCGJ_DICDI
ID ABCGJ_DICDI Reviewed; 1449 AA.
AC Q8T675; Q55C34;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=ABC transporter G family member 19;
DE AltName: Full=ABC transporter ABCG.19;
GN Name=abcG19; ORFNames=DDB_G0269208;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AF482396; AAL91503.1; -; Genomic_DNA.
DR EMBL; AAFI02000005; EAL71954.1; -; Genomic_DNA.
DR RefSeq; XP_646647.1; XM_641555.1.
DR AlphaFoldDB; Q8T675; -.
DR SMR; Q8T675; -.
DR STRING; 44689.DDB0191237; -.
DR PaxDb; Q8T675; -.
DR PRIDE; Q8T675; -.
DR EnsemblProtists; EAL71954; EAL71954; DDB_G0269208.
DR GeneID; 8617619; -.
DR KEGG; ddi:DDB_G0269208; -.
DR dictyBase; DDB_G0269208; abcG19.
DR eggNOG; KOG0065; Eukaryota.
DR HOGENOM; CLU_000604_35_0_1; -.
DR InParanoid; Q8T675; -.
DR OMA; PYCFLAT; -.
DR PhylomeDB; Q8T675; -.
DR PRO; PR:Q8T675; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IGC:dictyBase.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1449
FT /note="ABC transporter G family member 19"
FT /id="PRO_0000391403"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 634..654
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 747..767
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1155..1175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1188..1208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1228..1248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1266..1286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1293..1313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1423..1443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 130..383
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 488..715
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 818..1062
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1152..1386
FT /note="ABC transmembrane type-2 2"
FT BINDING 854..861
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1449 AA; 165585 MW; C0B0A01F4C02C1DE CRC64;
MKEFELNEYS FQEVENLNIN TPNNNNNFGV VGDDFQLNSP DIQNSENQFK YIANELETDS
KQYLSNLDAE NNHNENDEDF KLRKYFENSQ RVALGNGQKP KKMGVSVRNL TVVGVGADQS
VISDLSTPIF KILNLFKPST WKEKGSTFDI LHDITLFNRD GGMLLVLGRP GSGCSTLLRL
ISNQRGSYVE VKGDITYGGI PAKEWKRYQG ESIYTPEEDT HHPTLTVRQT LDFALKCKTI
HNRLPDEKKR TYRKRIFDLL LGMFGIVHQA DTIVGNEFIR GLSGGERKRL TITEAMVSSA
SITCYDCSTR GLDAASALDY AKSIRIMSDT LDKTTIASFY QASDSIYNLF DNVAVIEKGR
LIYFGPGNKA KQYFIDLGFD CEPRKSTPDF LTGVTNPQER IIRQGFEGRV PETFADFEAA
WRNSSMYRDM LEEQKEYERK IEIEQPAVDF IQEVKAEKSK TTSKRSIYTT SFLTQVKALI
VRNFQIIWGD KLSLGSRYLS VFTQSFVYGS IFYNLETNIN GLFTRGGTLF SVILFNALLC
ECEMPLTFGQ RGILQKQHSY AMYRPSALHI AQIVTDIPLT IIQVFLFSIV VYFMFGLQYD
AGKFFIFCFT LVGATLATTN LFRMFGNFSP SLYISQNVMN IFIISMITYT GYTIPKPKMH
PWFSWFYWCN PFSYAFKALM ANEFGDLSFD CQDTAIPSDP NKIIVYDNSY RICASPGASM
GNLTVSGSKY IEESFHFRSD DLTQNVFILY LWWILYIVLN MFAMEYFDWT GGGYSHKVYK
KGKAPKMNDV EEEKKQNQIV ANATSKMKDT LKMRGGIFTW QNINYTVPVK GGKRLLLDNV
EGWIKPGQMT ALMGSSGAGK TTLLDVLAKR KTMGEVQGKC FLNGKPLEID FERITGYVEQ
MDVHNPGLTV REALRFSAKL RQEPSVLLEE KFDYVEHVLE MMEMKHLGDA LIGTLETGVG
ISVEERKRLT IGVELVAKPH ILFLDEPTSG LDAQSSYNIV KFIRKLADAG MPLVCTIHQP
SSVLFEHFDR ILLLAKGGKT VYFGDIGEGS KTLTSYFERY GVRPCTESEN PAEYILEATG
AGVHGKSDVN WSETWKQSPE LQEIERELAA LEAQGPSSTE DHGKPREFAT PIWYQTIEVY
KRLNIIWWRD PFYTYGSFIQ ASMAGLIMGF TFWSLKGSSS DMSQRVFFIF ETLILGILLI
FVVLPQFIMQ QEYFKRDFAS KFYSWFPFAI SIVAVEIPIV IISGTFFFFC SFWTAGLYTK
FNEINFYFWF ILILYLLFCV SFGQAVSAIS FNLFLAHTLI PLLIVFLFLF CGVMVIPSSI
PTFWRGWVYH LNPCRYFMEG IVTNVLKHTD VKCTSEDFTH FTNPEAVNGV TCKQYFPISE
PLTGYVEAIN EGDESKCGYC LYNNGEEYYN TLGWSFDNRW RNLAILICFW IFNILMVITF
VYITRKPRR
