S35B4_HUMAN
ID S35B4_HUMAN Reviewed; 331 AA.
AC Q969S0; A4D1P3; A6NNS4; Q53GQ7; Q8TCU7; Q96K33;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter;
DE AltName: Full=Solute carrier family 35 member B4;
DE AltName: Full=YEA4 homolog;
GN Name=SLC35B4; Synonyms=YEA4; ORFNames=PSEC0055;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15911612; DOI=10.1074/jbc.m504783200;
RA Ashikov A., Routier F., Fuhlrott J., Helmus Y., Wild M., Gerardy-Schahn R.,
RA Bakker H.;
RT "The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide
RT sugar transporter with specificity for UDP-xylose and UDP-N-
RT acetylglucosamine.";
RL J. Biol. Chem. 280:27230-27235(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Liver;
RA Moriya Y., Ito K., Aburatani H., Suzuki H., Sugiyama Y.;
RT "Molecular cloning of full-length cDNA similar to Yeast Yea4p from human
RT liver cDNA library.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Kobayashi T., Burchell B.;
RT "Molecular cloning and characterisation of human yea4p.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 41-331 (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Liver;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from
CC cytosol into Golgi. {ECO:0000269|PubMed:15911612}.
CC -!- INTERACTION:
CC Q969S0; Q13520: AQP6; NbExp=3; IntAct=EBI-10281213, EBI-13059134;
CC Q969S0; P11912: CD79A; NbExp=3; IntAct=EBI-10281213, EBI-7797864;
CC Q969S0; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-10281213, EBI-1045797;
CC Q969S0; O00501: CLDN5; NbExp=3; IntAct=EBI-10281213, EBI-18400628;
CC Q969S0; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10281213, EBI-18013275;
CC Q969S0; Q96BA8: CREB3L1; NbExp=8; IntAct=EBI-10281213, EBI-6942903;
CC Q969S0; O00559: EBAG9; NbExp=3; IntAct=EBI-10281213, EBI-8787095;
CC Q969S0; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10281213, EBI-781551;
CC Q969S0; P30040: ERP29; NbExp=3; IntAct=EBI-10281213, EBI-946830;
CC Q969S0; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10281213, EBI-18304435;
CC Q969S0; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-10281213, EBI-18938272;
CC Q969S0; O15552: FFAR2; NbExp=3; IntAct=EBI-10281213, EBI-2833872;
CC Q969S0; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10281213, EBI-13345167;
CC Q969S0; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10281213, EBI-11721746;
CC Q969S0; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-10281213, EBI-18053395;
CC Q969S0; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-10281213, EBI-749265;
CC Q969S0; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-10281213, EBI-2820517;
CC Q969S0; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-10281213, EBI-6163737;
CC Q969S0; P15941-11: MUC1; NbExp=3; IntAct=EBI-10281213, EBI-17263240;
CC Q969S0; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-10281213, EBI-716063;
CC Q969S0; P15151: PVR; NbExp=3; IntAct=EBI-10281213, EBI-3919694;
CC Q969S0; Q9NX52-3: RHBDL2; NbExp=3; IntAct=EBI-10281213, EBI-12908426;
CC Q969S0; Q6ZMJ2-2: SCARA5; NbExp=3; IntAct=EBI-10281213, EBI-12823227;
CC Q969S0; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10281213, EBI-17595455;
CC Q969S0; P27105: STOM; NbExp=3; IntAct=EBI-10281213, EBI-1211440;
CC Q969S0; Q0VAB0: TBXA2R; NbExp=3; IntAct=EBI-10281213, EBI-18271435;
CC Q969S0; Q8N3G9: TMEM130; NbExp=3; IntAct=EBI-10281213, EBI-19763514;
CC Q969S0; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10281213, EBI-10982110;
CC Q969S0; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10281213, EBI-18178701;
CC Q969S0; O43914: TYROBP; NbExp=3; IntAct=EBI-10281213, EBI-2214794;
CC Q969S0; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-10281213, EBI-744988;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:15911612}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15911612}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q969S0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q969S0-2; Sequence=VSP_016197, VSP_016198;
CC Name=3;
CC IsoId=Q969S0-3; Sequence=VSP_016199, VSP_016200;
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55325.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ971941; CAI98963.1; -; mRNA.
DR EMBL; AB052892; BAB61040.1; -; mRNA.
DR EMBL; AJ315497; CAC84567.1; -; mRNA.
DR EMBL; AJ315498; CAC84568.1; -; mRNA.
DR EMBL; AK027603; BAB55225.1; -; mRNA.
DR EMBL; AK027726; BAB55325.1; ALT_INIT; mRNA.
DR EMBL; AK075368; BAC11573.1; -; mRNA.
DR EMBL; AK222874; BAD96594.1; -; mRNA.
DR EMBL; AC008154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24071.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83810.1; -; Genomic_DNA.
DR EMBL; BC008413; AAH08413.1; -; mRNA.
DR CCDS; CCDS34756.1; -. [Q969S0-1]
DR RefSeq; NP_116215.1; NM_032826.4. [Q969S0-1]
DR AlphaFoldDB; Q969S0; -.
DR BioGRID; 124349; 37.
DR IntAct; Q969S0; 33.
DR STRING; 9606.ENSP00000367770; -.
DR TCDB; 2.A.7.10.2; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q969S0; -.
DR PhosphoSitePlus; Q969S0; -.
DR SwissPalm; Q969S0; -.
DR BioMuta; SLC35B4; -.
DR DMDM; 74751727; -.
DR MassIVE; Q969S0; -.
DR MaxQB; Q969S0; -.
DR PaxDb; Q969S0; -.
DR PeptideAtlas; Q969S0; -.
DR PRIDE; Q969S0; -.
DR ProteomicsDB; 75824; -. [Q969S0-1]
DR ProteomicsDB; 75825; -. [Q969S0-2]
DR ProteomicsDB; 75826; -. [Q969S0-3]
DR Antibodypedia; 53731; 39 antibodies from 12 providers.
DR DNASU; 84912; -.
DR Ensembl; ENST00000378509.9; ENSP00000367770.4; ENSG00000205060.11. [Q969S0-1]
DR Ensembl; ENST00000470969.2; ENSP00000485857.1; ENSG00000205060.11. [Q969S0-2]
DR GeneID; 84912; -.
DR KEGG; hsa:84912; -.
DR MANE-Select; ENST00000378509.9; ENSP00000367770.4; NM_032826.5; NP_116215.1.
DR UCSC; uc003vrn.4; human. [Q969S0-1]
DR CTD; 84912; -.
DR DisGeNET; 84912; -.
DR GeneCards; SLC35B4; -.
DR HGNC; HGNC:20584; SLC35B4.
DR HPA; ENSG00000205060; Low tissue specificity.
DR MIM; 610923; gene.
DR neXtProt; NX_Q969S0; -.
DR OpenTargets; ENSG00000205060; -.
DR PharmGKB; PA134922110; -.
DR VEuPathDB; HostDB:ENSG00000205060; -.
DR eggNOG; KOG1583; Eukaryota.
DR GeneTree; ENSGT00390000002915; -.
DR HOGENOM; CLU_033007_1_0_1; -.
DR InParanoid; Q969S0; -.
DR OMA; NYAFDFN; -.
DR OrthoDB; 1209974at2759; -.
DR PhylomeDB; Q969S0; -.
DR TreeFam; TF312926; -.
DR PathwayCommons; Q969S0; -.
DR Reactome; R-HSA-727802; Transport of nucleotide sugars.
DR SignaLink; Q969S0; -.
DR BioGRID-ORCS; 84912; 7 hits in 1073 CRISPR screens.
DR ChiTaRS; SLC35B4; human.
DR GeneWiki; SLC35B4; -.
DR GenomeRNAi; 84912; -.
DR Pharos; Q969S0; Tbio.
DR PRO; PR:Q969S0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q969S0; protein.
DR Bgee; ENSG00000205060; Expressed in cerebellar vermis and 173 other tissues.
DR ExpressionAtlas; Q969S0; baseline and differential.
DR Genevisible; Q969S0; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:CACAO.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030173; C:integral component of Golgi membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0005464; F:UDP-xylose transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0006111; P:regulation of gluconeogenesis; IEA:Ensembl.
DR GO; GO:1990569; P:UDP-N-acetylglucosamine transmembrane transport; IDA:UniProtKB.
DR GO; GO:0015790; P:UDP-xylose transmembrane transport; IDA:UniProtKB.
DR InterPro; IPR013657; UAA.
DR PANTHER; PTHR10778; PTHR10778; 1.
DR Pfam; PF08449; UAA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..331
FT /note="UDP-xylose and UDP-N-acetylglucosamine transporter"
FT /id="PRO_0000213385"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 225..231
FT /note="ELYEIPV -> GEFGVRQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_016197"
FT VAR_SEQ 232..331
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_016198"
FT VAR_SEQ 251..253
FT /note="YVC -> TPT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016199"
FT VAR_SEQ 254..331
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016200"
FT CONFLICT 21
FT /note="L -> P (in Ref. 6; BAD96594)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="F -> S (in Ref. 6; BAD96594)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="I -> M (in Ref. 6; BAD96594)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="P -> S (in Ref. 6; BAD96594)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 331 AA; 37424 MW; 8C305DE30EFD4F82 CRC64;
MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA
IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK
YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGIF
QETLYKRFGK HSKEALFYNH ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW
FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N
