ID   S35B4_MACFA             Reviewed;         331 AA.
AC   Q95KB4; Q9BE34;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Solute carrier family 35 member B4;
GN   Name=SLC35B4; ORFNames=QccE-22467, QmoA-11096;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain cortex, and Medulla oblongata;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC       UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from
CC       cytosol into Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95KB4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95KB4-2; Sequence=VSP_016201, VSP_016202;
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB060201; BAB41143.1; -; mRNA.
DR   EMBL; AB063006; BAB60758.1; -; mRNA.
DR   AlphaFoldDB; Q95KB4; -.
DR   STRING; 9541.XP_005550871.1; -.
DR   eggNOG; KOG1583; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="UDP-xylose and UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213386"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         103..166
FT                   /note="ANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGF
FT                   QAFVWWLLGIGA -> HPHHGVRLPHRHARRDPTQICEPHLFHLVLPEPLHPVALAGHP
FT                   VCLHWDLNVHRGVEQPRDHKK (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_016201"
FT   VAR_SEQ         167..331
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_016202"
FT   CONFLICT        80
FT                   /note="N -> D (in Ref. 1; BAB41143)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   331 AA;  37394 MW;  BA2E3DD7E5E3E6F5 CRC64;
     MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA
     IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK
     YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGIF
     QETLYKQFGK HSKEALFYNH ALPLPGFIFL ASDIYDHAVL FNKSELYEIP GIGVTLPIMW
     FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
     LFVFIGTLMY TEVWNNLGTT KSEPQKDNKK N