ID   S35B4_PONAB             Reviewed;         331 AA.
AC   Q5R8M3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=UDP-xylose and UDP-N-acetylglucosamine transporter;
DE   AltName: Full=Solute carrier family 35 member B4;
GN   Name=SLC35B4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sugar transporter that specifically mediates the transport of
CC       UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from
CC       cytosol into Golgi. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35B
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR859728; CAH91887.1; -; mRNA.
DR   RefSeq; NP_001126093.1; NM_001132621.1.
DR   AlphaFoldDB; Q5R8M3; -.
DR   STRING; 9601.ENSPPYP00000020214; -.
DR   Ensembl; ENSPPYT00000021007; ENSPPYP00000020214; ENSPPYG00000018016.
DR   GeneID; 100173046; -.
DR   KEGG; pon:100173046; -.
DR   CTD; 84912; -.
DR   eggNOG; KOG1583; Eukaryota.
DR   GeneTree; ENSGT00390000002915; -.
DR   HOGENOM; CLU_033007_1_0_1; -.
DR   InParanoid; Q5R8M3; -.
DR   OMA; NYAFDFN; -.
DR   OrthoDB; 1209974at2759; -.
DR   TreeFam; TF312926; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0005464; F:UDP-xylose transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006111; P:regulation of gluconeogenesis; IEA:Ensembl.
DR   InterPro; IPR013657; UAA.
DR   PANTHER; PTHR10778; PTHR10778; 1.
DR   Pfam; PF08449; UAA; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="UDP-xylose and UDP-N-acetylglucosamine transporter"
FT                   /id="PRO_0000213388"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  37424 MW;  FE177DC35BFD4AD2 CRC64;
     MRPALAVGLV FAGCCSNVIF LELLARKHPG CGNIVTFAQF LFIAVEGFLF EADLGRKPPA
     IPIRYYAIMV TMFFTVSVVN NYALNLNIAM PLHMIFRSGS LIANMILGII ILKKRYSIFK
     YTSIALVSVG IFICTFMSAK QVTSQSSLSE NDGFQAFVWW LLGIGALTFA LLMSARMGLF
     QETLYKRFGK HSKEALFYNH ALPLPGFVFL ASDIYDHAVL FNKSELYEIP VIGVTLPIMW
     FYLLMNIITQ YVCIRGVFIL TTECASLTVT LVVTLRKFVS LIFSILYFQN PFTLWHWLGT
     LFVFIGTLMY TEVWNNLGTT KSEPQKDSKK N