位置:首页 > 蛋白库 > S35C2_HUMAN
S35C2_HUMAN
ID   S35C2_HUMAN             Reviewed;         365 AA.
AC   Q9NQQ7; B7Z6V6; E1P5T0; Q53GK3; Q5JW05; Q96CJ8; Q9Y304;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Solute carrier family 35 member C2;
DE   AltName: Full=Ovarian cancer-overexpressed gene 1 protein;
GN   Name=SLC35C2; Synonyms=C20orf5, OVCOV1; ORFNames=CGI-15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX   PubMed=11856893; DOI=10.1159/000048828;
RA   Leach R.E., Duniec-Dmuchowski Z.M., Tanaka T.S., Ko M.S.H., Krawetz S.A.;
RT   "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band
RT   q13.1-->q13.2 by fluorescent in situ hybridization.";
RL   Cytogenet. Cell Genet. 94:252-253(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA   Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT   "Identification of novel human genes evolutionarily conserved in
RT   Caenorhabditis elegans by comparative proteomics.";
RL   Genome Res. 10:703-713(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Spleen;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Kidney;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, Colon, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   CHARACTERIZATION.
RX   PubMed=12461647; DOI=10.1007/s00335-002-2185-4;
RA   Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H.,
RA   Armant D.R., Krawetz S.A.;
RT   "Identification, molecular characterization, and tissue expression of
RT   OVCOV1.";
RL   Mamm. Genome 13:619-624(2002).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT   networks.";
RL   Cell 127:635-648(2006).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19413330; DOI=10.1021/ac9004309;
RA   Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT   "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT   refined SCX-based approach.";
RL   Anal. Chem. 81:4493-4501(2009).
RN   [12]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=20837470; DOI=10.1074/jbc.m110.126003;
RA   Lu L., Hou X., Shi S., Korner C., Stanley P.;
RT   "Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch
RT   signaling in mammalian cells.";
RL   J. Biol. Chem. 285:36245-36254(2010).
RN   [13]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [14]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [15]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-336, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May play an important role in the cellular response to tissue
CC       hypoxia. May be either a GDP-fucose transporter that competes with
CC       SLC35C1 for GDP-fucose, or a factor that otherwise enhances the
CC       fucosylation of Notch and is required for optimal Notch signaling in
CC       mammalian cells. {ECO:0000269|PubMed:20837470}.
CC   -!- INTERACTION:
CC       Q9NQQ7-3; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-17295964, EBI-2876927;
CC       Q9NQQ7-3; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-17295964, EBI-10827839;
CC       Q9NQQ7-3; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-17295964, EBI-2803601;
CC       Q9NQQ7-3; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-17295964, EBI-1754287;
CC       Q9NQQ7-3; P05090: APOD; NbExp=3; IntAct=EBI-17295964, EBI-715495;
CC       Q9NQQ7-3; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-17295964, EBI-714543;
CC       Q9NQQ7-3; P07306: ASGR1; NbExp=3; IntAct=EBI-17295964, EBI-1172335;
CC       Q9NQQ7-3; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-17295964, EBI-12069500;
CC       Q9NQQ7-3; Q92843: BCL2L2; NbExp=3; IntAct=EBI-17295964, EBI-707714;
CC       Q9NQQ7-3; O95393: BMP10; NbExp=3; IntAct=EBI-17295964, EBI-3922513;
CC       Q9NQQ7-3; P06681: C2; NbExp=3; IntAct=EBI-17295964, EBI-2835920;
CC       Q9NQQ7-3; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-17295964, EBI-12003442;
CC       Q9NQQ7-3; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-17295964, EBI-9083477;
CC       Q9NQQ7-3; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-17295964, EBI-12256978;
CC       Q9NQQ7-3; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-17295964, EBI-11522780;
CC       Q9NQQ7-3; O95406: CNIH1; NbExp=3; IntAct=EBI-17295964, EBI-12172273;
CC       Q9NQQ7-3; P29400-2: COL4A5; NbExp=3; IntAct=EBI-17295964, EBI-12211159;
CC       Q9NQQ7-3; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-17295964, EBI-6942903;
CC       Q9NQQ7-3; P49447: CYB561; NbExp=3; IntAct=EBI-17295964, EBI-8646596;
CC       Q9NQQ7-3; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-17295964, EBI-2680384;
CC       Q9NQQ7-3; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-17295964, EBI-8639143;
CC       Q9NQQ7-3; P52803: EFNA5; NbExp=3; IntAct=EBI-17295964, EBI-1753674;
CC       Q9NQQ7-3; P54852: EMP3; NbExp=3; IntAct=EBI-17295964, EBI-3907816;
CC       Q9NQQ7-3; Q92520: FAM3C; NbExp=3; IntAct=EBI-17295964, EBI-2876774;
CC       Q9NQQ7-3; P37268: FDFT1; NbExp=3; IntAct=EBI-17295964, EBI-714550;
CC       Q9NQQ7-3; O15552: FFAR2; NbExp=3; IntAct=EBI-17295964, EBI-2833872;
CC       Q9NQQ7-3; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-17295964, EBI-12175685;
CC       Q9NQQ7-3; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-17295964, EBI-713304;
CC       Q9NQQ7-3; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-17295964, EBI-6166686;
CC       Q9NQQ7-3; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-17295964, EBI-17231387;
CC       Q9NQQ7-3; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-17295964, EBI-13345167;
CC       Q9NQQ7-3; P11215: ITGAM; NbExp=3; IntAct=EBI-17295964, EBI-2568251;
CC       Q9NQQ7-3; O43561-2: LAT; NbExp=3; IntAct=EBI-17295964, EBI-8070286;
CC       Q9NQQ7-3; O95214: LEPROTL1; NbExp=3; IntAct=EBI-17295964, EBI-750776;
CC       Q9NQQ7-3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-17295964, EBI-2820517;
CC       Q9NQQ7-3; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-17295964, EBI-12033434;
CC       Q9NQQ7-3; P21145: MAL; NbExp=3; IntAct=EBI-17295964, EBI-3932027;
CC       Q9NQQ7-3; Q969L2: MAL2; NbExp=3; IntAct=EBI-17295964, EBI-944295;
CC       Q9NQQ7-3; Q13021: MALL; NbExp=3; IntAct=EBI-17295964, EBI-750078;
CC       Q9NQQ7-3; P11836: MS4A1; NbExp=3; IntAct=EBI-17295964, EBI-2808234;
CC       Q9NQQ7-3; Q8N912: NRAC; NbExp=3; IntAct=EBI-17295964, EBI-12051377;
CC       Q9NQQ7-3; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17295964, EBI-10262547;
CC       Q9NQQ7-3; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-17295964, EBI-1054848;
CC       Q9NQQ7-3; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-17295964, EBI-721750;
CC       Q9NQQ7-3; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-17295964, EBI-16427978;
CC       Q9NQQ7-3; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-17295964, EBI-981985;
CC       Q9NQQ7-3; P26678: PLN; NbExp=3; IntAct=EBI-17295964, EBI-692836;
CC       Q9NQQ7-3; Q04941: PLP2; NbExp=3; IntAct=EBI-17295964, EBI-608347;
CC       Q9NQQ7-3; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-17295964, EBI-8652812;
CC       Q9NQQ7-3; A5D903: PRB1; NbExp=3; IntAct=EBI-17295964, EBI-10173935;
CC       Q9NQQ7-3; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-17295964, EBI-8636004;
CC       Q9NQQ7-3; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-17295964, EBI-3917235;
CC       Q9NQQ7-3; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-17295964, EBI-8652744;
CC       Q9NQQ7-3; O75396: SEC22B; NbExp=3; IntAct=EBI-17295964, EBI-1058865;
CC       Q9NQQ7-3; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-17295964, EBI-9679163;
CC       Q9NQQ7-3; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-17295964, EBI-10329948;
CC       Q9NQQ7-3; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-17295964, EBI-18159983;
CC       Q9NQQ7-3; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-17295964, EBI-12854384;
CC       Q9NQQ7-3; Q99726: SLC30A3; NbExp=3; IntAct=EBI-17295964, EBI-10294651;
CC       Q9NQQ7-3; Q5T1Q4: SLC35F1; NbExp=3; IntAct=EBI-17295964, EBI-13365456;
CC       Q9NQQ7-3; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-17295964, EBI-12889586;
CC       Q9NQQ7-3; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-17295964, EBI-8640191;
CC       Q9NQQ7-3; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-17295964, EBI-17280858;
CC       Q9NQQ7-3; P0DN84: STRIT1; NbExp=3; IntAct=EBI-17295964, EBI-12200293;
CC       Q9NQQ7-3; Q13277: STX3; NbExp=3; IntAct=EBI-17295964, EBI-1394295;
CC       Q9NQQ7-3; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-17295964, EBI-726331;
CC       Q9NQQ7-3; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-17295964, EBI-13075176;
CC       Q9NQQ7-3; Q03518: TAP1; NbExp=3; IntAct=EBI-17295964, EBI-747259;
CC       Q9NQQ7-3; P07204: THBD; NbExp=3; IntAct=EBI-17295964, EBI-941422;
CC       Q9NQQ7-3; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-17295964, EBI-12845616;
CC       Q9NQQ7-3; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17295964, EBI-8638294;
CC       Q9NQQ7-3; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-17295964, EBI-11528917;
CC       Q9NQQ7-3; P56557: TMEM50B; NbExp=3; IntAct=EBI-17295964, EBI-12366453;
CC       Q9NQQ7-3; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-17295964, EBI-6656213;
CC       Q9NQQ7-3; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-17295964, EBI-12015604;
CC       Q9NQQ7-3; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-17295964, EBI-17249488;
CC       Q9NQQ7-3; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-17295964, EBI-12003468;
CC       Q9NQQ7-3; O60636: TSPAN2; NbExp=3; IntAct=EBI-17295964, EBI-3914288;
CC       Q9NQQ7-3; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-17295964, EBI-12045841;
CC       Q9NQQ7-3; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-17295964, EBI-11343401;
CC       Q9NQQ7-3; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-17295964, EBI-4401271;
CC       Q9NQQ7-3; O75841: UPK1B; NbExp=3; IntAct=EBI-17295964, EBI-12237619;
CC       Q9NQQ7-3; O95292: VAPB; NbExp=3; IntAct=EBI-17295964, EBI-1188298;
CC       Q9NQQ7-3; P15692-12: VEGFA; NbExp=3; IntAct=EBI-17295964, EBI-6622053;
CC       Q9NQQ7-3; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-17295964, EBI-723716;
CC       Q9NQQ7-3; O95070: YIF1A; NbExp=3; IntAct=EBI-17295964, EBI-2799703;
CC       Q9NQQ7-3; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-17295964, EBI-751253;
CC       Q9NQQ7-3; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-17295964, EBI-751210;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000269|PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane {ECO:0000269|PubMed:20837470}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q9NQQ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NQQ7-2; Sequence=VSP_009229;
CC       Name=3;
CC         IsoId=Q9NQQ7-3; Sequence=VSP_056729;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed although the level of
CC       expression is tissue dependent. Overexpressed in ovarian cancer.
CC   -!- INDUCTION: In hypoxic trophoblast cells.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD27724.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF455052; AAL59605.1; -; mRNA.
DR   EMBL; AF132949; AAD27724.1; ALT_FRAME; mRNA.
DR   EMBL; AK301022; BAH13392.1; -; mRNA.
DR   EMBL; AK222928; BAD96648.1; -; mRNA.
DR   EMBL; AL133227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471077; EAW75748.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75747.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75750.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75751.1; -; Genomic_DNA.
DR   EMBL; CH471077; EAW75752.1; -; Genomic_DNA.
DR   EMBL; BC014191; AAH14191.1; -; mRNA.
DR   EMBL; BC021138; AAH21138.1; -; mRNA.
DR   EMBL; BC025277; AAH25277.1; -; mRNA.
DR   CCDS; CCDS13396.1; -. [Q9NQQ7-1]
DR   CCDS; CCDS13397.1; -. [Q9NQQ7-2]
DR   CCDS; CCDS63292.1; -. [Q9NQQ7-3]
DR   RefSeq; NP_001268386.1; NM_001281457.1.
DR   RefSeq; NP_001268387.1; NM_001281458.1. [Q9NQQ7-3]
DR   RefSeq; NP_001268388.1; NM_001281459.1.
DR   RefSeq; NP_001268389.1; NM_001281460.1. [Q9NQQ7-1]
DR   RefSeq; NP_057029.8; NM_015945.11. [Q9NQQ7-1]
DR   RefSeq; NP_775096.1; NM_173073.3. [Q9NQQ7-2]
DR   RefSeq; NP_775271.1; NM_173179.3. [Q9NQQ7-1]
DR   RefSeq; XP_011527133.1; XM_011528831.1. [Q9NQQ7-1]
DR   RefSeq; XP_011527134.1; XM_011528832.1. [Q9NQQ7-1]
DR   RefSeq; XP_011527135.1; XM_011528833.1. [Q9NQQ7-1]
DR   RefSeq; XP_016883345.1; XM_017027856.1.
DR   RefSeq; XP_016883346.1; XM_017027857.1.
DR   RefSeq; XP_016883347.1; XM_017027858.1.
DR   RefSeq; XP_016883348.1; XM_017027859.1.
DR   RefSeq; XP_016883349.1; XM_017027860.1.
DR   RefSeq; XP_016883350.1; XM_017027861.1. [Q9NQQ7-2]
DR   AlphaFoldDB; Q9NQQ7; -.
DR   SMR; Q9NQQ7; -.
DR   BioGRID; 119214; 104.
DR   IntAct; Q9NQQ7; 90.
DR   MINT; Q9NQQ7; -.
DR   STRING; 9606.ENSP00000318960; -.
DR   TCDB; 2.A.7.9.16; the drug/metabolite transporter (dmt) superfamily.
DR   GlyGen; Q9NQQ7; 1 site.
DR   iPTMnet; Q9NQQ7; -.
DR   PhosphoSitePlus; Q9NQQ7; -.
DR   BioMuta; SLC35C2; -.
DR   DMDM; 41017506; -.
DR   jPOST; Q9NQQ7; -.
DR   MassIVE; Q9NQQ7; -.
DR   MaxQB; Q9NQQ7; -.
DR   PaxDb; Q9NQQ7; -.
DR   PeptideAtlas; Q9NQQ7; -.
DR   PRIDE; Q9NQQ7; -.
DR   ProteomicsDB; 82169; -. [Q9NQQ7-1]
DR   ProteomicsDB; 82170; -. [Q9NQQ7-2]
DR   TopDownProteomics; Q9NQQ7-2; -. [Q9NQQ7-2]
DR   Antibodypedia; 53835; 49 antibodies from 14 providers.
DR   DNASU; 51006; -.
DR   Ensembl; ENST00000243896.6; ENSP00000243896.2; ENSG00000080189.15. [Q9NQQ7-1]
DR   Ensembl; ENST00000317734.12; ENSP00000318960.9; ENSG00000080189.15. [Q9NQQ7-3]
DR   Ensembl; ENST00000372227.5; ENSP00000361301.1; ENSG00000080189.15. [Q9NQQ7-1]
DR   Ensembl; ENST00000372230.10; ENSP00000361304.5; ENSG00000080189.15. [Q9NQQ7-1]
DR   Ensembl; ENST00000543605.5; ENSP00000439974.2; ENSG00000080189.15. [Q9NQQ7-2]
DR   GeneID; 51006; -.
DR   KEGG; hsa:51006; -.
DR   MANE-Select; ENST00000372230.10; ENSP00000361304.5; NM_015945.12; NP_057029.8.
DR   UCSC; uc002xrp.5; human. [Q9NQQ7-1]
DR   CTD; 51006; -.
DR   GeneCards; SLC35C2; -.
DR   HGNC; HGNC:17117; SLC35C2.
DR   HPA; ENSG00000080189; Low tissue specificity.
DR   MIM; 619530; gene.
DR   neXtProt; NX_Q9NQQ7; -.
DR   OpenTargets; ENSG00000080189; -.
DR   PharmGKB; PA32850; -.
DR   VEuPathDB; HostDB:ENSG00000080189; -.
DR   eggNOG; KOG1443; Eukaryota.
DR   GeneTree; ENSGT00510000048078; -.
DR   HOGENOM; CLU_022332_1_3_1; -.
DR   InParanoid; Q9NQQ7; -.
DR   OMA; PVCAAMN; -.
DR   OrthoDB; 1337371at2759; -.
DR   PhylomeDB; Q9NQQ7; -.
DR   TreeFam; TF314994; -.
DR   PathwayCommons; Q9NQQ7; -.
DR   SignaLink; Q9NQQ7; -.
DR   BioGRID-ORCS; 51006; 17 hits in 1083 CRISPR screens.
DR   ChiTaRS; SLC35C2; human.
DR   GeneWiki; SLC35C2; -.
DR   GenomeRNAi; 51006; -.
DR   Pharos; Q9NQQ7; Tdark.
DR   PRO; PR:Q9NQQ7; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q9NQQ7; protein.
DR   Bgee; ENSG00000080189; Expressed in tendon of biceps brachii and 165 other tissues.
DR   ExpressionAtlas; Q9NQQ7; baseline and differential.
DR   Genevisible; Q9NQQ7; HS.
DR   GO; GO:0005801; C:cis-Golgi network; IDA:MGI.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:MGI.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0036066; P:protein O-linked fucosylation; IEA:Ensembl.
DR   GO; GO:0015786; P:UDP-glucose transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Golgi apparatus; Membrane;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..365
FT                   /note="Solute carrier family 35 member C2"
FT                   /id="PRO_0000213399"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          344..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         335
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18669648,
FT                   ECO:0007744|PubMed:23186163"
FT   MOD_RES         336
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MGRVSTSHQPLRGVPAPADSGAPVLQPPRM (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056729"
FT   VAR_SEQ         137..157
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_009229"
FT   CONFLICT        66
FT                   /note="L -> S (in Ref. 2; AAD27724)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        126
FT                   /note="I -> V (in Ref. 4; BAD96648)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        247
FT                   /note="F -> L (in Ref. 3; BAH13392)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   365 AA;  40432 MW;  5EACE6A4953411A9 CRC64;
     MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS
     ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA
     VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW
     TLTQMLLQKA ELGLQNPIDT MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL
     RVLGSLFLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
     LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE GDNEEEEYFV
     AQGQQ
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024