S35C2_HUMAN
ID S35C2_HUMAN Reviewed; 365 AA.
AC Q9NQQ7; B7Z6V6; E1P5T0; Q53GK3; Q5JW05; Q96CJ8; Q9Y304;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Solute carrier family 35 member C2;
DE AltName: Full=Ovarian cancer-overexpressed gene 1 protein;
GN Name=SLC35C2; Synonyms=C20orf5, OVCOV1; ORFNames=CGI-15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=11856893; DOI=10.1159/000048828;
RA Leach R.E., Duniec-Dmuchowski Z.M., Tanaka T.S., Ko M.S.H., Krawetz S.A.;
RT "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band
RT q13.1-->q13.2 by fluorescent in situ hybridization.";
RL Cytogenet. Cell Genet. 94:252-253(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP CHARACTERIZATION.
RX PubMed=12461647; DOI=10.1007/s00335-002-2185-4;
RA Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H.,
RA Armant D.R., Krawetz S.A.;
RT "Identification, molecular characterization, and tissue expression of
RT OVCOV1.";
RL Mamm. Genome 13:619-624(2002).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [12]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=20837470; DOI=10.1074/jbc.m110.126003;
RA Lu L., Hou X., Shi S., Korner C., Stanley P.;
RT "Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch
RT signaling in mammalian cells.";
RL J. Biol. Chem. 285:36245-36254(2010).
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-336, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May play an important role in the cellular response to tissue
CC hypoxia. May be either a GDP-fucose transporter that competes with
CC SLC35C1 for GDP-fucose, or a factor that otherwise enhances the
CC fucosylation of Notch and is required for optimal Notch signaling in
CC mammalian cells. {ECO:0000269|PubMed:20837470}.
CC -!- INTERACTION:
CC Q9NQQ7-3; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-17295964, EBI-2876927;
CC Q9NQQ7-3; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-17295964, EBI-10827839;
CC Q9NQQ7-3; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-17295964, EBI-2803601;
CC Q9NQQ7-3; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-17295964, EBI-1754287;
CC Q9NQQ7-3; P05090: APOD; NbExp=3; IntAct=EBI-17295964, EBI-715495;
CC Q9NQQ7-3; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-17295964, EBI-714543;
CC Q9NQQ7-3; P07306: ASGR1; NbExp=3; IntAct=EBI-17295964, EBI-1172335;
CC Q9NQQ7-3; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-17295964, EBI-12069500;
CC Q9NQQ7-3; Q92843: BCL2L2; NbExp=3; IntAct=EBI-17295964, EBI-707714;
CC Q9NQQ7-3; O95393: BMP10; NbExp=3; IntAct=EBI-17295964, EBI-3922513;
CC Q9NQQ7-3; P06681: C2; NbExp=3; IntAct=EBI-17295964, EBI-2835920;
CC Q9NQQ7-3; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-17295964, EBI-12003442;
CC Q9NQQ7-3; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-17295964, EBI-9083477;
CC Q9NQQ7-3; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-17295964, EBI-12256978;
CC Q9NQQ7-3; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-17295964, EBI-11522780;
CC Q9NQQ7-3; O95406: CNIH1; NbExp=3; IntAct=EBI-17295964, EBI-12172273;
CC Q9NQQ7-3; P29400-2: COL4A5; NbExp=3; IntAct=EBI-17295964, EBI-12211159;
CC Q9NQQ7-3; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-17295964, EBI-6942903;
CC Q9NQQ7-3; P49447: CYB561; NbExp=3; IntAct=EBI-17295964, EBI-8646596;
CC Q9NQQ7-3; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-17295964, EBI-2680384;
CC Q9NQQ7-3; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-17295964, EBI-8639143;
CC Q9NQQ7-3; P52803: EFNA5; NbExp=3; IntAct=EBI-17295964, EBI-1753674;
CC Q9NQQ7-3; P54852: EMP3; NbExp=3; IntAct=EBI-17295964, EBI-3907816;
CC Q9NQQ7-3; Q92520: FAM3C; NbExp=3; IntAct=EBI-17295964, EBI-2876774;
CC Q9NQQ7-3; P37268: FDFT1; NbExp=3; IntAct=EBI-17295964, EBI-714550;
CC Q9NQQ7-3; O15552: FFAR2; NbExp=3; IntAct=EBI-17295964, EBI-2833872;
CC Q9NQQ7-3; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-17295964, EBI-12175685;
CC Q9NQQ7-3; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-17295964, EBI-713304;
CC Q9NQQ7-3; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-17295964, EBI-6166686;
CC Q9NQQ7-3; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-17295964, EBI-17231387;
CC Q9NQQ7-3; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-17295964, EBI-13345167;
CC Q9NQQ7-3; P11215: ITGAM; NbExp=3; IntAct=EBI-17295964, EBI-2568251;
CC Q9NQQ7-3; O43561-2: LAT; NbExp=3; IntAct=EBI-17295964, EBI-8070286;
CC Q9NQQ7-3; O95214: LEPROTL1; NbExp=3; IntAct=EBI-17295964, EBI-750776;
CC Q9NQQ7-3; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-17295964, EBI-2820517;
CC Q9NQQ7-3; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-17295964, EBI-12033434;
CC Q9NQQ7-3; P21145: MAL; NbExp=3; IntAct=EBI-17295964, EBI-3932027;
CC Q9NQQ7-3; Q969L2: MAL2; NbExp=3; IntAct=EBI-17295964, EBI-944295;
CC Q9NQQ7-3; Q13021: MALL; NbExp=3; IntAct=EBI-17295964, EBI-750078;
CC Q9NQQ7-3; P11836: MS4A1; NbExp=3; IntAct=EBI-17295964, EBI-2808234;
CC Q9NQQ7-3; Q8N912: NRAC; NbExp=3; IntAct=EBI-17295964, EBI-12051377;
CC Q9NQQ7-3; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17295964, EBI-10262547;
CC Q9NQQ7-3; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-17295964, EBI-1054848;
CC Q9NQQ7-3; Q8N138: ORMDL3; NbExp=3; IntAct=EBI-17295964, EBI-721750;
CC Q9NQQ7-3; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-17295964, EBI-16427978;
CC Q9NQQ7-3; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-17295964, EBI-981985;
CC Q9NQQ7-3; P26678: PLN; NbExp=3; IntAct=EBI-17295964, EBI-692836;
CC Q9NQQ7-3; Q04941: PLP2; NbExp=3; IntAct=EBI-17295964, EBI-608347;
CC Q9NQQ7-3; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-17295964, EBI-8652812;
CC Q9NQQ7-3; A5D903: PRB1; NbExp=3; IntAct=EBI-17295964, EBI-10173935;
CC Q9NQQ7-3; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-17295964, EBI-8636004;
CC Q9NQQ7-3; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-17295964, EBI-3917235;
CC Q9NQQ7-3; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-17295964, EBI-8652744;
CC Q9NQQ7-3; O75396: SEC22B; NbExp=3; IntAct=EBI-17295964, EBI-1058865;
CC Q9NQQ7-3; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-17295964, EBI-9679163;
CC Q9NQQ7-3; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-17295964, EBI-10329948;
CC Q9NQQ7-3; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-17295964, EBI-18159983;
CC Q9NQQ7-3; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-17295964, EBI-12854384;
CC Q9NQQ7-3; Q99726: SLC30A3; NbExp=3; IntAct=EBI-17295964, EBI-10294651;
CC Q9NQQ7-3; Q5T1Q4: SLC35F1; NbExp=3; IntAct=EBI-17295964, EBI-13365456;
CC Q9NQQ7-3; Q6ZP29-3: SLC66A1; NbExp=3; IntAct=EBI-17295964, EBI-12889586;
CC Q9NQQ7-3; Q9NRQ5: SMCO4; NbExp=3; IntAct=EBI-17295964, EBI-8640191;
CC Q9NQQ7-3; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-17295964, EBI-17280858;
CC Q9NQQ7-3; P0DN84: STRIT1; NbExp=3; IntAct=EBI-17295964, EBI-12200293;
CC Q9NQQ7-3; Q13277: STX3; NbExp=3; IntAct=EBI-17295964, EBI-1394295;
CC Q9NQQ7-3; Q9H7V2: SYNDIG1; NbExp=3; IntAct=EBI-17295964, EBI-726331;
CC Q9NQQ7-3; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-17295964, EBI-13075176;
CC Q9NQQ7-3; Q03518: TAP1; NbExp=3; IntAct=EBI-17295964, EBI-747259;
CC Q9NQQ7-3; P07204: THBD; NbExp=3; IntAct=EBI-17295964, EBI-941422;
CC Q9NQQ7-3; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-17295964, EBI-12845616;
CC Q9NQQ7-3; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17295964, EBI-8638294;
CC Q9NQQ7-3; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-17295964, EBI-11528917;
CC Q9NQQ7-3; P56557: TMEM50B; NbExp=3; IntAct=EBI-17295964, EBI-12366453;
CC Q9NQQ7-3; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-17295964, EBI-6656213;
CC Q9NQQ7-3; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-17295964, EBI-12015604;
CC Q9NQQ7-3; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-17295964, EBI-17249488;
CC Q9NQQ7-3; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-17295964, EBI-12003468;
CC Q9NQQ7-3; O60636: TSPAN2; NbExp=3; IntAct=EBI-17295964, EBI-3914288;
CC Q9NQQ7-3; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-17295964, EBI-12045841;
CC Q9NQQ7-3; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-17295964, EBI-11343401;
CC Q9NQQ7-3; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-17295964, EBI-4401271;
CC Q9NQQ7-3; O75841: UPK1B; NbExp=3; IntAct=EBI-17295964, EBI-12237619;
CC Q9NQQ7-3; O95292: VAPB; NbExp=3; IntAct=EBI-17295964, EBI-1188298;
CC Q9NQQ7-3; P15692-12: VEGFA; NbExp=3; IntAct=EBI-17295964, EBI-6622053;
CC Q9NQQ7-3; Q9UEU0: VTI1B; NbExp=3; IntAct=EBI-17295964, EBI-723716;
CC Q9NQQ7-3; O95070: YIF1A; NbExp=3; IntAct=EBI-17295964, EBI-2799703;
CC Q9NQQ7-3; Q9BSR8: YIPF4; NbExp=3; IntAct=EBI-17295964, EBI-751253;
CC Q9NQQ7-3; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-17295964, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000269|PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000269|PubMed:20837470}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NQQ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NQQ7-2; Sequence=VSP_009229;
CC Name=3;
CC IsoId=Q9NQQ7-3; Sequence=VSP_056729;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed although the level of
CC expression is tissue dependent. Overexpressed in ovarian cancer.
CC -!- INDUCTION: In hypoxic trophoblast cells.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD27724.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF455052; AAL59605.1; -; mRNA.
DR EMBL; AF132949; AAD27724.1; ALT_FRAME; mRNA.
DR EMBL; AK301022; BAH13392.1; -; mRNA.
DR EMBL; AK222928; BAD96648.1; -; mRNA.
DR EMBL; AL133227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW75748.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75747.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75750.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75751.1; -; Genomic_DNA.
DR EMBL; CH471077; EAW75752.1; -; Genomic_DNA.
DR EMBL; BC014191; AAH14191.1; -; mRNA.
DR EMBL; BC021138; AAH21138.1; -; mRNA.
DR EMBL; BC025277; AAH25277.1; -; mRNA.
DR CCDS; CCDS13396.1; -. [Q9NQQ7-1]
DR CCDS; CCDS13397.1; -. [Q9NQQ7-2]
DR CCDS; CCDS63292.1; -. [Q9NQQ7-3]
DR RefSeq; NP_001268386.1; NM_001281457.1.
DR RefSeq; NP_001268387.1; NM_001281458.1. [Q9NQQ7-3]
DR RefSeq; NP_001268388.1; NM_001281459.1.
DR RefSeq; NP_001268389.1; NM_001281460.1. [Q9NQQ7-1]
DR RefSeq; NP_057029.8; NM_015945.11. [Q9NQQ7-1]
DR RefSeq; NP_775096.1; NM_173073.3. [Q9NQQ7-2]
DR RefSeq; NP_775271.1; NM_173179.3. [Q9NQQ7-1]
DR RefSeq; XP_011527133.1; XM_011528831.1. [Q9NQQ7-1]
DR RefSeq; XP_011527134.1; XM_011528832.1. [Q9NQQ7-1]
DR RefSeq; XP_011527135.1; XM_011528833.1. [Q9NQQ7-1]
DR RefSeq; XP_016883345.1; XM_017027856.1.
DR RefSeq; XP_016883346.1; XM_017027857.1.
DR RefSeq; XP_016883347.1; XM_017027858.1.
DR RefSeq; XP_016883348.1; XM_017027859.1.
DR RefSeq; XP_016883349.1; XM_017027860.1.
DR RefSeq; XP_016883350.1; XM_017027861.1. [Q9NQQ7-2]
DR AlphaFoldDB; Q9NQQ7; -.
DR SMR; Q9NQQ7; -.
DR BioGRID; 119214; 104.
DR IntAct; Q9NQQ7; 90.
DR MINT; Q9NQQ7; -.
DR STRING; 9606.ENSP00000318960; -.
DR TCDB; 2.A.7.9.16; the drug/metabolite transporter (dmt) superfamily.
DR GlyGen; Q9NQQ7; 1 site.
DR iPTMnet; Q9NQQ7; -.
DR PhosphoSitePlus; Q9NQQ7; -.
DR BioMuta; SLC35C2; -.
DR DMDM; 41017506; -.
DR jPOST; Q9NQQ7; -.
DR MassIVE; Q9NQQ7; -.
DR MaxQB; Q9NQQ7; -.
DR PaxDb; Q9NQQ7; -.
DR PeptideAtlas; Q9NQQ7; -.
DR PRIDE; Q9NQQ7; -.
DR ProteomicsDB; 82169; -. [Q9NQQ7-1]
DR ProteomicsDB; 82170; -. [Q9NQQ7-2]
DR TopDownProteomics; Q9NQQ7-2; -. [Q9NQQ7-2]
DR Antibodypedia; 53835; 49 antibodies from 14 providers.
DR DNASU; 51006; -.
DR Ensembl; ENST00000243896.6; ENSP00000243896.2; ENSG00000080189.15. [Q9NQQ7-1]
DR Ensembl; ENST00000317734.12; ENSP00000318960.9; ENSG00000080189.15. [Q9NQQ7-3]
DR Ensembl; ENST00000372227.5; ENSP00000361301.1; ENSG00000080189.15. [Q9NQQ7-1]
DR Ensembl; ENST00000372230.10; ENSP00000361304.5; ENSG00000080189.15. [Q9NQQ7-1]
DR Ensembl; ENST00000543605.5; ENSP00000439974.2; ENSG00000080189.15. [Q9NQQ7-2]
DR GeneID; 51006; -.
DR KEGG; hsa:51006; -.
DR MANE-Select; ENST00000372230.10; ENSP00000361304.5; NM_015945.12; NP_057029.8.
DR UCSC; uc002xrp.5; human. [Q9NQQ7-1]
DR CTD; 51006; -.
DR GeneCards; SLC35C2; -.
DR HGNC; HGNC:17117; SLC35C2.
DR HPA; ENSG00000080189; Low tissue specificity.
DR MIM; 619530; gene.
DR neXtProt; NX_Q9NQQ7; -.
DR OpenTargets; ENSG00000080189; -.
DR PharmGKB; PA32850; -.
DR VEuPathDB; HostDB:ENSG00000080189; -.
DR eggNOG; KOG1443; Eukaryota.
DR GeneTree; ENSGT00510000048078; -.
DR HOGENOM; CLU_022332_1_3_1; -.
DR InParanoid; Q9NQQ7; -.
DR OMA; PVCAAMN; -.
DR OrthoDB; 1337371at2759; -.
DR PhylomeDB; Q9NQQ7; -.
DR TreeFam; TF314994; -.
DR PathwayCommons; Q9NQQ7; -.
DR SignaLink; Q9NQQ7; -.
DR BioGRID-ORCS; 51006; 17 hits in 1083 CRISPR screens.
DR ChiTaRS; SLC35C2; human.
DR GeneWiki; SLC35C2; -.
DR GenomeRNAi; 51006; -.
DR Pharos; Q9NQQ7; Tdark.
DR PRO; PR:Q9NQQ7; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NQQ7; protein.
DR Bgee; ENSG00000080189; Expressed in tendon of biceps brachii and 165 other tissues.
DR ExpressionAtlas; Q9NQQ7; baseline and differential.
DR Genevisible; Q9NQQ7; HS.
DR GO; GO:0005801; C:cis-Golgi network; IDA:MGI.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0036066; P:protein O-linked fucosylation; IEA:Ensembl.
DR GO; GO:0015786; P:UDP-glucose transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..365
FT /note="Solute carrier family 35 member C2"
FT /id="PRO_0000213399"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 344..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MGRVSTSHQPLRGVPAPADSGAPVLQPPRM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056729"
FT VAR_SEQ 137..157
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009229"
FT CONFLICT 66
FT /note="L -> S (in Ref. 2; AAD27724)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="I -> V (in Ref. 4; BAD96648)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="F -> L (in Ref. 3; BAH13392)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 365 AA; 40432 MW; 5EACE6A4953411A9 CRC64;
MGRWALDVAF LWKAVLTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS
ALSRALVQCS SHRARVVLSW ADYLRRVAPT ALATALDVGL SNWSFLYVTV SLYTMTKSSA
VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW
TLTQMLLQKA ELGLQNPIDT MFHLQPLMFL GLFPLFAVFE GLHLSTSEKI FRFQDTGLLL
RVLGSLFLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
LGFALCLSGI SLHVALKALH SRGDGGPKAL KGLGSSPDLE LLLRSSQREE GDNEEEEYFV
AQGQQ
