S35C2_MOUSE
ID S35C2_MOUSE Reviewed; 364 AA.
AC Q8VCX2;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier family 35 member C2;
DE AltName: Full=Ovarian cancer-overexpressed gene 1 protein;
GN Name=Slc35c2; Synonyms=Ovcov1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP DEVELOPMENTAL STAGE.
RX PubMed=12461647; DOI=10.1007/s00335-002-2185-4;
RA Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H.,
RA Armant D.R., Krawetz S.A.;
RT "Identification, molecular characterization, and tissue expression of
RT OVCOV1.";
RL Mamm. Genome 13:619-624(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play an important role in the cellular response to tissue
CC hypoxia. May be either a GDP-fucose transporter that competes with
CC SLC35C1 for GDP-fucose, or a factor that otherwise enhances the
CC fucosylation of Notch and is required for optimal Notch signaling in
CC mammalian cells (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment
CC membrane {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Higher expression at embryo stage 7.5 dpc than 11-
CC 17 dpc. {ECO:0000269|PubMed:12461647}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC {ECO:0000305}.
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DR EMBL; BC018327; AAH18327.1; -; mRNA.
DR CCDS; CCDS17074.1; -.
DR RefSeq; NP_001239502.1; NM_001252573.1.
DR RefSeq; NP_001239503.1; NM_001252574.1.
DR RefSeq; NP_659142.1; NM_144893.2.
DR RefSeq; XP_006499433.1; XM_006499370.3.
DR RefSeq; XP_006499434.1; XM_006499371.3.
DR RefSeq; XP_006499435.1; XM_006499372.3.
DR RefSeq; XP_006499438.1; XM_006499375.3.
DR AlphaFoldDB; Q8VCX2; -.
DR SMR; Q8VCX2; -.
DR STRING; 10090.ENSMUSP00000104923; -.
DR TCDB; 2.A.7.9.8; the drug/metabolite transporter (dmt) superfamily.
DR GlyGen; Q8VCX2; 1 site.
DR iPTMnet; Q8VCX2; -.
DR PhosphoSitePlus; Q8VCX2; -.
DR jPOST; Q8VCX2; -.
DR MaxQB; Q8VCX2; -.
DR PaxDb; Q8VCX2; -.
DR PRIDE; Q8VCX2; -.
DR ProteomicsDB; 256885; -.
DR Antibodypedia; 53835; 49 antibodies from 14 providers.
DR DNASU; 228875; -.
DR Ensembl; ENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
DR Ensembl; ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
DR Ensembl; ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
DR Ensembl; ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
DR GeneID; 228875; -.
DR KEGG; mmu:228875; -.
DR UCSC; uc008nxd.2; mouse.
DR CTD; 51006; -.
DR MGI; MGI:2385166; Slc35c2.
DR VEuPathDB; HostDB:ENSMUSG00000017664; -.
DR eggNOG; KOG1443; Eukaryota.
DR GeneTree; ENSGT00510000048078; -.
DR HOGENOM; CLU_022332_1_3_1; -.
DR InParanoid; Q8VCX2; -.
DR OMA; PVCAAMN; -.
DR OrthoDB; 1337371at2759; -.
DR PhylomeDB; Q8VCX2; -.
DR TreeFam; TF314994; -.
DR BioGRID-ORCS; 228875; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Slc35c2; mouse.
DR PRO; PR:Q8VCX2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VCX2; protein.
DR Bgee; ENSMUSG00000017664; Expressed in lacrimal gland and 257 other tissues.
DR ExpressionAtlas; Q8VCX2; baseline and differential.
DR Genevisible; Q8VCX2; MM.
DR GO; GO:0005801; C:cis-Golgi network; ISO:MGI.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0036065; P:fucosylation; IDA:MGI.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:MGI.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:MGI.
DR GO; GO:0036066; P:protein O-linked fucosylation; IDA:MGI.
DR GO; GO:0015786; P:UDP-glucose transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..364
FT /note="Solute carrier family 35 member C2"
FT /id="PRO_0000213400"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQQ7"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 364 AA; 40302 MW; 334B742A566FB891 CRC64;
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS
ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL SNWSFLYITV SLYTMTKSSA
VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW
TLTQILLQKA DLGLQNPIDT MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL
WVLGSLLLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE EDGEEEYFVT
QGQQ
