ID   S35D2_BOVIN             Reviewed;         355 AA.
AC   A2VE55;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter;
DE   AltName: Full=Solute carrier family 35 member D2;
GN   Name=SLC35D2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antiporter transporting nucleotide sugars such as UDP-N-
CC       acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose
CC       (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange
CC       for the corresponding nucleosides monophosphates (UMP for UDP-sugars
CC       and GMP for GDP-sugars). May take part in heparan sulfate synthesis by
CC       supplying UDP-GlcNAc, the donor substrate, and thus be involved in
CC       growth factor signaling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC133580; AAI33581.1; -; mRNA.
DR   RefSeq; NP_001075928.1; NM_001082459.2.
DR   AlphaFoldDB; A2VE55; -.
DR   SMR; A2VE55; -.
DR   STRING; 9913.ENSBTAP00000007164; -.
DR   PaxDb; A2VE55; -.
DR   PRIDE; A2VE55; -.
DR   Ensembl; ENSBTAT00000007164; ENSBTAP00000007164; ENSBTAG00000005445.
DR   GeneID; 613734; -.
DR   KEGG; bta:613734; -.
DR   CTD; 23169; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005445; -.
DR   VGNC; VGNC:34828; SLC35D1.
DR   eggNOG; KOG1444; Eukaryota.
DR   GeneTree; ENSGT00940000155665; -.
DR   HOGENOM; CLU_040726_1_0_1; -.
DR   InParanoid; A2VE55; -.
DR   OMA; IQSTVCV; -.
DR   OrthoDB; 1093260at2759; -.
DR   TreeFam; TF313307; -.
DR   Reactome; R-BTA-173599; Formation of the active cofactor, UDP-glucuronate.
DR   Reactome; R-BTA-727802; Transport of nucleotide sugars.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000005445; Expressed in oocyte and 100 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005461; F:UDP-glucuronic acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005463; F:UDP-N-acetylgalactosamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..355
FT                   /note="UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose
FT                   transporter"
FT                   /id="PRO_0000313079"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..68
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..156
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..253
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        275..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..314
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        336..355
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   355 AA;  39280 MW;  4F45D60684F90A30 CRC64;
     MAEVHRRQHA RVKGEAPAKS STHRHEEELG MASAETLTVF LKLLAAGFYG VSSFLIVVVN
     KSVLTNYRFP SSLCVGLGQM VATVAVLWVG KALRVVKFPD FDRNVPRKTF PLPLLYFGNQ
     ITGLFSTKKL NLPMFTVLRR FSILFTMFAE GVLLKKTFSW GIKMTVFAMI IGAFVAASSD
     LAFDLEGYVF ILINDVLTAA NGAYVKQKLD SKELGKYGLL YYNALFMILP TLAIAYFTGD
     AQKALDFEGW ADTLFLLQFT LSCVMGFILM YATVLCTQYN SALTTTIVGC IKNILITYIG
     MVFGGDYIFT WTNFIGLNIS IAGSLVYSYI TFSEEQLSKQ SEASSKLDIK GKGAV