BEPF_BRUSU
ID BEPF_BRUSU Reviewed; 411 AA.
AC Q8FWV8; G0KC76;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Efflux pump periplasmic linker BepF;
GN Name=bepF; OrderedLocusNames=BRA0335, BS1330_II0332;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
RN [3]
RP FUNCTION IN RESISTANCE, SUBUNIT, AND INDUCTION.
RC STRAIN=1330;
RX PubMed=19201794; DOI=10.1128/jb.01198-08;
RA Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D.,
RA Zorreguieta A.;
RT "Interplay between two RND systems mediating antimicrobial resistance in
RT Brucella suis.";
RL J. Bacteriol. 191:2530-2540(2009).
CC -!- FUNCTION: May contribute to resistance to some drugs, such as
CC deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence
CC of BepD and BepE. {ECO:0000269|PubMed:19201794}.
CC -!- SUBUNIT: Probably part of a tripartite efflux pump, which is composed
CC of an outer membrane efflux protein, an inner membrane protein and a
CC protein that expands the periplasmic space. Could form a tripartite
CC pump with BepC and BepG. {ECO:0000269|PubMed:19201794}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC -!- INDUCTION: Induced in the absence of BepD and BepE.
CC {ECO:0000269|PubMed:19201794}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000305}.
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DR EMBL; AE014292; AAN33535.1; -; Genomic_DNA.
DR EMBL; CP002998; AEM19814.1; -; Genomic_DNA.
DR RefSeq; WP_004690093.1; NZ_KN046805.1.
DR AlphaFoldDB; Q8FWV8; -.
DR SMR; Q8FWV8; -.
DR EnsemblBacteria; AEM19814; AEM19814; BS1330_II0332.
DR GeneID; 45053394; -.
DR GeneID; 55592033; -.
DR KEGG; bms:BRA0335; -.
DR KEGG; bsi:BS1330_II0332; -.
DR PATRIC; fig|204722.21.peg.170; -.
DR HOGENOM; CLU_018816_2_1_5; -.
DR OMA; LFRIMPK; -.
DR PhylomeDB; Q8FWV8; -.
DR Proteomes; UP000007104; Chromosome II.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR Pfam; PF16576; HlyD_D23; 1.
DR TIGRFAMs; TIGR01730; RND_mfp; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Periplasm; Transport.
FT CHAIN 1..411
FT /note="Efflux pump periplasmic linker BepF"
FT /id="PRO_0000390649"
FT COILED 118..196
FT /evidence="ECO:0000255"
SQ SEQUENCE 411 AA; 43995 MW; 5CFA08DBA6B0AAC5 CRC64;
MVAFWTCRNA WFQHLPFAKR GDENAPSGPR RLRPWFLVLA LGLAACSEDK SAPQQAAPLP
PIPVGVIKIT ERPTHPQLSF VGRVEATDSV DLIARVDGFL DKRTFTEGQA VKTGDLLFVL
QKDALQAALD AAQANLAKAQ ADADNLKLQT ERARSLYKQK TVSQAMLDDR VAAEKQALAV
VQQAQASLEQ AQINLGYTDI RAPFSGRIGM ANFSVGALVG PSSGPLATIV SQDPIYVTFP
VSDKTILDLT EGGRTATDRS NVAVSLTLSN GMTYPQTGAI DFTGIKINPN TDTLMVRAQF
PNPNNVLIDG QYVQVTAASK HPVEALLVPQ KAIMTDQSGN YVLAVGEDNK VIQRQITQGS
TFGSNVVVKS GLAVGDQVVV DGLQRIRPGQ KVDPQIVDAT TPAQKAMSVG N