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BEPF_BRUSU
ID   BEPF_BRUSU              Reviewed;         411 AA.
AC   Q8FWV8; G0KC76;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Efflux pump periplasmic linker BepF;
GN   Name=bepF; OrderedLocusNames=BRA0335, BS1330_II0332;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
RN   [3]
RP   FUNCTION IN RESISTANCE, SUBUNIT, AND INDUCTION.
RC   STRAIN=1330;
RX   PubMed=19201794; DOI=10.1128/jb.01198-08;
RA   Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D.,
RA   Zorreguieta A.;
RT   "Interplay between two RND systems mediating antimicrobial resistance in
RT   Brucella suis.";
RL   J. Bacteriol. 191:2530-2540(2009).
CC   -!- FUNCTION: May contribute to resistance to some drugs, such as
CC       deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence
CC       of BepD and BepE. {ECO:0000269|PubMed:19201794}.
CC   -!- SUBUNIT: Probably part of a tripartite efflux pump, which is composed
CC       of an outer membrane efflux protein, an inner membrane protein and a
CC       protein that expands the periplasmic space. Could form a tripartite
CC       pump with BepC and BepG. {ECO:0000269|PubMed:19201794}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- INDUCTION: Induced in the absence of BepD and BepE.
CC       {ECO:0000269|PubMed:19201794}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; AE014292; AAN33535.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19814.1; -; Genomic_DNA.
DR   RefSeq; WP_004690093.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FWV8; -.
DR   SMR; Q8FWV8; -.
DR   EnsemblBacteria; AEM19814; AEM19814; BS1330_II0332.
DR   GeneID; 45053394; -.
DR   GeneID; 55592033; -.
DR   KEGG; bms:BRA0335; -.
DR   KEGG; bsi:BS1330_II0332; -.
DR   PATRIC; fig|204722.21.peg.170; -.
DR   HOGENOM; CLU_018816_2_1_5; -.
DR   OMA; LFRIMPK; -.
DR   PhylomeDB; Q8FWV8; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Periplasm; Transport.
FT   CHAIN           1..411
FT                   /note="Efflux pump periplasmic linker BepF"
FT                   /id="PRO_0000390649"
FT   COILED          118..196
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   411 AA;  43995 MW;  5CFA08DBA6B0AAC5 CRC64;
     MVAFWTCRNA WFQHLPFAKR GDENAPSGPR RLRPWFLVLA LGLAACSEDK SAPQQAAPLP
     PIPVGVIKIT ERPTHPQLSF VGRVEATDSV DLIARVDGFL DKRTFTEGQA VKTGDLLFVL
     QKDALQAALD AAQANLAKAQ ADADNLKLQT ERARSLYKQK TVSQAMLDDR VAAEKQALAV
     VQQAQASLEQ AQINLGYTDI RAPFSGRIGM ANFSVGALVG PSSGPLATIV SQDPIYVTFP
     VSDKTILDLT EGGRTATDRS NVAVSLTLSN GMTYPQTGAI DFTGIKINPN TDTLMVRAQF
     PNPNNVLIDG QYVQVTAASK HPVEALLVPQ KAIMTDQSGN YVLAVGEDNK VIQRQITQGS
     TFGSNVVVKS GLAVGDQVVV DGLQRIRPGQ KVDPQIVDAT TPAQKAMSVG N
 
 
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