ID   S35D2_PIG               Reviewed;         343 AA.
AC   Q15B89;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter;
DE   AltName: Full=Solute carrier family 35 member D2;
DE   Flags: Fragment;
GN   Name=SLC35D2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16978188; DOI=10.1111/j.1365-2052.2006.01499.x;
RA   Kim J.H., Lim H.T., Park E.W., Ovilo C., Lee J.H., Jeon J.T.;
RT   "A gene-based radiation hybrid map of the pig chromosome 6q32 region
RT   associated with a QTL for fat deposition traits.";
RL   Anim. Genet. 37:522-523(2006).
CC   -!- FUNCTION: Antiporter transporting nucleotide sugars such as UDP-N-
CC       acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose
CC       (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange
CC       for the corresponding nucleosides monophosphates (UMP for UDP-sugars
CC       and GMP for GDP-sugars). May take part in heparan sulfate synthesis by
CC       supplying UDP-Glc-NAc, the donor substrate, and thus be involved in
CC       growth factor signaling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ529289; ABG21116.1; -; mRNA.
DR   AlphaFoldDB; Q15B89; -.
DR   SMR; Q15B89; -.
DR   STRING; 9823.ENSSSCP00000004112; -.
DR   PaxDb; Q15B89; -.
DR   eggNOG; KOG1444; Eukaryota.
DR   InParanoid; Q15B89; -.
DR   ChiTaRS; SLC35D2; pig.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005461; F:UDP-glucuronic acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005463; F:UDP-N-acetylgalactosamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           <1..343
FT                   /note="UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose
FT                   transporter"
FT                   /id="PRO_0000313082"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..56
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..204
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..241
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..302
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        324..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   343 AA;  37806 MW;  E4D7119590B01378 CRC64;
     KGEAPAKSST HRHDEELGMA SAETLTVFLK LLAAGFYGVS SFLIVVVNKS VLTNYRFPSS
     LCVGLGQMVA TVAVLWVGKA LRVVKFPDFD RNVPRKTFPL PLLYFGNQIT GLFSTKKLNL
     PMFTVLRRFS ILFTMFAEGV LLKKTFSWGI KMTVFAMIIG AFVAASSDLA FDLEGYVFIL
     INDVLTAANG AYVKQKLDSK ELGKYGLLYY NALFMILPTL AIAYITGDAQ KAMDFEGWAD
     TLFLLQFTLS CVMGFILMYA TVLCTQYNSA LTTTIVGCIK NILITYIGMV FGGDYIFTWT
     NFIGLNISIA GSLVYSYITF SEEQLSKQSE ASNKLDNKGK GAV