S35D3_MOUSE
ID S35D3_MOUSE Reviewed; 422 AA.
AC Q8BGF8; Q9CXD4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Solute carrier family 35 member D3;
DE AltName: Full=Fringe connection-like protein 1;
GN Name=Slc35d3; Synonyms=Frcl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Corpus striatum, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17062724; DOI=10.1182/blood-2006-08-040196;
RA Chintala S., Tan J., Gautam R., Rusiniak M.E., Guo X., Li W., Gahl W.A.,
RA Huizing M., Spritz R.A., Hutton S., Novak E.K., Swank R.T.;
RT "The Slc35d3 gene, encoding an orphan nucleotide sugar transporter,
RT regulates platelet-dense granules.";
RL Blood 109:1533-1540(2007).
CC -!- FUNCTION: May play a role in hemostasis as a regulator of the
CC biosynthesis of platelet-dense granules. {ECO:0000269|PubMed:17062724}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:17062724}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35D subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31067.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK018094; BAB31067.1; ALT_SEQ; mRNA.
DR EMBL; AK042761; BAC31356.1; -; mRNA.
DR EMBL; AK044973; BAC32165.1; -; mRNA.
DR EMBL; AK047610; BAC33098.1; -; mRNA.
DR CCDS; CCDS23719.1; -.
DR RefSeq; NP_083805.1; NM_029529.3.
DR AlphaFoldDB; Q8BGF8; -.
DR SMR; Q8BGF8; -.
DR STRING; 10090.ENSMUSP00000060589; -.
DR iPTMnet; Q8BGF8; -.
DR PhosphoSitePlus; Q8BGF8; -.
DR MaxQB; Q8BGF8; -.
DR PaxDb; Q8BGF8; -.
DR PRIDE; Q8BGF8; -.
DR ProteomicsDB; 260774; -.
DR Antibodypedia; 33021; 71 antibodies from 23 providers.
DR DNASU; 76157; -.
DR Ensembl; ENSMUST00000059805; ENSMUSP00000060589; ENSMUSG00000050473.
DR GeneID; 76157; -.
DR KEGG; mmu:76157; -.
DR UCSC; uc007enk.1; mouse.
DR CTD; 340146; -.
DR MGI; MGI:1923407; Slc35d3.
DR VEuPathDB; HostDB:ENSMUSG00000050473; -.
DR eggNOG; KOG1444; Eukaryota.
DR GeneTree; ENSGT00940000160083; -.
DR HOGENOM; CLU_040726_3_0_1; -.
DR InParanoid; Q8BGF8; -.
DR OMA; VRGTKYM; -.
DR OrthoDB; 972218at2759; -.
DR PhylomeDB; Q8BGF8; -.
DR TreeFam; TF313307; -.
DR BioGRID-ORCS; 76157; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q8BGF8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BGF8; protein.
DR Bgee; ENSMUSG00000050473; Expressed in striatum and 36 other tissues.
DR ExpressionAtlas; Q8BGF8; baseline and differential.
DR Genevisible; Q8BGF8; MM.
DR GO; GO:0005769; C:early endosome; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005461; F:UDP-glucuronic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005463; F:UDP-N-acetylgalactosamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005462; F:UDP-N-acetylglucosamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0097009; P:energy homeostasis; IMP:MGI.
DR GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IMP:MGI.
DR GO; GO:0032527; P:protein exit from endoplasmic reticulum; IMP:MGI.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..422
FT /note="Solute carrier family 35 member D3"
FT /id="PRO_0000307728"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 339..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 383
FT /note="S -> F (in Ref. 1; BAB31067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 422 AA; 44917 MW; 9CACD625C45507D8 CRC64;
MRQLCRGRVL GISVAIAHGV FSGSLNILLK FLISRYQFSF LTLVQCLTSS TAALSLELLR
RLGLIAVPPF GLSLARSFAG VAVLSTLQSS LTLWSLRGLS LPMYVVFKRC LPLVTMLIGV
LVLKNGAPSP GVLAAVLITT CGAALAGAGD LTGDPIGYVT GVLAVLVHAA YLVLIQKASA
DTEHGPLTAQ YVIAVSATPL LVICSFASTD SIHAWTFPGW KDPAMVSIFV ACILIGCAMN
FTTLHCTYIN SAVTTSFVGV VKSIATITVG MVAFSDVEPT SLFIAGVVVN TLGSIIYCVA
KFLETRRQSN YEDLESQAEG EERQPSGDQL PFVMEELPAK SGNSEPESAE GAGDSVQQGG
QESRGSIRGI SLAARSSRAE GHSDEVGRRS LKDTYLEVWR LVRGTKYMKK DYLMENEALP
SP
