S35E1_HUMAN
ID S35E1_HUMAN Reviewed; 410 AA.
AC Q96K37; Q8NBQ2; Q96JV7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Solute carrier family 35 member E1;
GN Name=SLC35E1; ORFNames=PSEC0038;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Rectum tumor;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-410 (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-410 (ISOFORM 1).
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96K37; Q9BXU8: FTHL17; NbExp=3; IntAct=EBI-720094, EBI-12156897;
CC Q96K37; Q00013: MPP1; NbExp=3; IntAct=EBI-720094, EBI-711788;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96K37-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96K37-2; Sequence=VSP_010139;
CC Name=3;
CC IsoId=Q96K37-3; Sequence=VSP_031351, VSP_010140, VSP_010141;
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH14557.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAH62562.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB55306.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB55410.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11565.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX640756; CAE45863.1; -; mRNA.
DR EMBL; BC062562; AAH62562.1; ALT_INIT; mRNA.
DR EMBL; BC014557; AAH14557.1; ALT_FRAME; mRNA.
DR EMBL; AK027699; BAB55306.1; ALT_INIT; mRNA.
DR EMBL; AK027850; BAB55410.1; ALT_INIT; mRNA.
DR EMBL; AK075355; BAC11565.1; ALT_INIT; mRNA.
DR CCDS; CCDS12346.2; -. [Q96K37-1]
DR RefSeq; NP_079157.3; NM_024881.4. [Q96K37-1]
DR AlphaFoldDB; Q96K37; -.
DR SMR; Q96K37; -.
DR BioGRID; 123013; 99.
DR IntAct; Q96K37; 42.
DR MINT; Q96K37; -.
DR STRING; 9606.ENSP00000470652; -.
DR TCDB; 2.A.7.9.9; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q96K37; -.
DR PhosphoSitePlus; Q96K37; -.
DR SwissPalm; Q96K37; -.
DR BioMuta; SLC35E1; -.
DR DMDM; 172045863; -.
DR EPD; Q96K37; -.
DR jPOST; Q96K37; -.
DR MassIVE; Q96K37; -.
DR MaxQB; Q96K37; -.
DR PaxDb; Q96K37; -.
DR PeptideAtlas; Q96K37; -.
DR PRIDE; Q96K37; -.
DR ProteomicsDB; 77038; -. [Q96K37-1]
DR ProteomicsDB; 77039; -. [Q96K37-2]
DR Antibodypedia; 3098; 41 antibodies from 11 providers.
DR DNASU; 79939; -.
DR Ensembl; ENST00000595753.6; ENSP00000470652.1; ENSG00000127526.15. [Q96K37-1]
DR GeneID; 79939; -.
DR KEGG; hsa:79939; -.
DR MANE-Select; ENST00000595753.6; ENSP00000470652.1; NM_024881.5; NP_079157.3.
DR UCSC; uc010xph.3; human. [Q96K37-1]
DR CTD; 79939; -.
DR DisGeNET; 79939; -.
DR GeneCards; SLC35E1; -.
DR HGNC; HGNC:20803; SLC35E1.
DR HPA; ENSG00000127526; Low tissue specificity.
DR neXtProt; NX_Q96K37; -.
DR OpenTargets; ENSG00000127526; -.
DR PharmGKB; PA134916810; -.
DR VEuPathDB; HostDB:ENSG00000127526; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00940000159007; -.
DR HOGENOM; CLU_019048_1_0_1; -.
DR InParanoid; Q96K37; -.
DR OMA; FWYTVSS; -.
DR PhylomeDB; Q96K37; -.
DR TreeFam; TF324822; -.
DR PathwayCommons; Q96K37; -.
DR SignaLink; Q96K37; -.
DR BioGRID-ORCS; 79939; 26 hits in 1083 CRISPR screens.
DR ChiTaRS; SLC35E1; human.
DR GenomeRNAi; 79939; -.
DR Pharos; Q96K37; Tdark.
DR PRO; PR:Q96K37; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96K37; protein.
DR Bgee; ENSG00000127526; Expressed in renal medulla and 215 other tissues.
DR ExpressionAtlas; Q96K37; baseline and differential.
DR Genevisible; Q96K37; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..410
FT /note="Solute carrier family 35 member E1"
FT /id="PRO_0000071941"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 363
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 1..300
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010139"
FT VAR_SEQ 1..156
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_031351"
FT VAR_SEQ 253..260
FT /note="TYVYQWPW -> GLPSENVL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_010140"
FT VAR_SEQ 261..410
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_010141"
FT CONFLICT 242
FT /note="D -> V (in Ref. 1; CAE45863)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="N -> I (in Ref. 4; BAC11565)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 410 AA; 44773 MW; 691D67A89A1D2114 CRC64;
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV ILSAFPFPVT
VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG PLLPPRFYPR YVLPLAFGKY
FASVSAHVSI WKVPVSYAHT VKATMPIWVV LLSRIIMKEK QSTKVYLSLI PIISGVLLAT
VTELSFDMWG LVSALAATLC FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL
VDLSAFLVSS DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV TTADLSSKER
HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP NSYSLNRYDV
