ID   S35E1_RAT               Reviewed;         409 AA.
AC   P0C6B1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Solute carrier family 35 member E1;
GN   Name=Slc35e1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AABR03100834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR03100344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001102577.2; NM_001109107.2.
DR   AlphaFoldDB; P0C6B1; -.
DR   SMR; P0C6B1; -.
DR   STRING; 10116.ENSRNOP00000016399; -.
DR   jPOST; P0C6B1; -.
DR   PaxDb; P0C6B1; -.
DR   PRIDE; P0C6B1; -.
DR   Ensembl; ENSRNOT00000016399; ENSRNOP00000016399; ENSRNOG00000012287.
DR   GeneID; 498599; -.
DR   KEGG; rno:498599; -.
DR   UCSC; RGD:1561342; rat.
DR   CTD; 79939; -.
DR   RGD; 1561342; Slc35e1.
DR   eggNOG; KOG1441; Eukaryota.
DR   GeneTree; ENSGT00940000159007; -.
DR   InParanoid; P0C6B1; -.
DR   OrthoDB; 1453018at2759; -.
DR   PhylomeDB; P0C6B1; -.
DR   PRO; PR:P0C6B1; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   3: Inferred from homology;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..409
FT                   /note="Solute carrier family 35 member E1"
FT                   /id="PRO_0000319069"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         363
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96K37"
SQ   SEQUENCE   409 AA;  44384 MW;  91A6C5786622EBF4 CRC64;
     MAAAAAAGPG AGAGIPGASG GGGAREGARV AALCLLWYAL SAGGNVVNKV ILSAFPFPVT
     VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPASG PLLPPRFYPR YVLPLAFGKY
     FASVSAHVSI WKVPVSYAHT VKATMPIWVV LLSRIIMKEK QSTKVYLSLV PIISGVLLAT
     VTELSFDVWG LVSALAATLC FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL
     VDLSTFLVSS DLAYVSQWPW TLLLLVVSGF CNFAQNVIAF SILNLISPLS YSVANATKRI
     MVIAVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARRHLLPV STSDLSNREH
     LRSPMEKPHN GALFPQQGDF QYRNILLTDH FQYSRQGHPN SYALSRHDV