BEPG_BRUSU
ID BEPG_BRUSU Reviewed; 1074 AA.
AC Q8FWV9; G0KC75;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Efflux pump membrane transporter BepG;
GN Name=bepG; OrderedLocusNames=BRA0334, BS1330_II0331;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
RN [3]
RP FUNCTION IN RESISTANCE, SUBUNIT, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=1330;
RX PubMed=19201794; DOI=10.1128/jb.01198-08;
RA Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D.,
RA Zorreguieta A.;
RT "Interplay between two RND systems mediating antimicrobial resistance in
RT Brucella suis.";
RL J. Bacteriol. 191:2530-2540(2009).
CC -!- FUNCTION: May contribute to resistance to some drugs, such as
CC deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence
CC of BepD and BepE. {ECO:0000269|PubMed:19201794}.
CC -!- SUBUNIT: Probably part of a tripartite efflux pump, which is composed
CC of an outer membrane efflux protein, an inner membrane protein and a
CC protein that expands the periplasmic space. Could form a tripartite
CC pump with BepC and BepF. {ECO:0000269|PubMed:19201794}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Induced in the absence of BepDE.
CC {ECO:0000269|PubMed:19201794}.
CC -!- DISRUPTION PHENOTYPE: Shows no differences in the resistance profile to
CC different dyes, detergents and antimicrobials.
CC {ECO:0000269|PubMed:19201794}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000305}.
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DR EMBL; AE014292; AAN33534.1; -; Genomic_DNA.
DR EMBL; CP002998; AEM19813.1; -; Genomic_DNA.
DR RefSeq; WP_006191785.1; NZ_KN046805.1.
DR AlphaFoldDB; Q8FWV9; -.
DR SMR; Q8FWV9; -.
DR EnsemblBacteria; AEM19813; AEM19813; BS1330_II0331.
DR GeneID; 45053393; -.
DR KEGG; bms:BRA0334; -.
DR KEGG; bsi:BS1330_II0331; -.
DR PATRIC; fig|204722.22.peg.3114; -.
DR HOGENOM; CLU_002755_1_1_5; -.
DR OMA; QYESFII; -.
DR PhylomeDB; Q8FWV9; -.
DR Proteomes; UP000007104; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.2090.10; -; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; HAE1.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
DR TIGRFAMs; TIGR00915; 2A0602; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1074
FT /note="Efflux pump membrane transporter BepG"
FT /id="PRO_0000390651"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 876..896
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 930..950
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 975..995
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1007..1027
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1050..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 114902 MW; 79F0B440F8A96438 CRC64;
MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY PGASAETVEA
AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD PNLNTVNVQN RVRLAEANLP
QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY DELFLNNYGV INVVDRLARV PGVGQAQSFG
TFNYSMRIWF NTDALTSLNL TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG
RLTDAKQFEN IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN
AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF VLVVVVVFIF
LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM ILAIGIVVDD AIVVVENVER
VMAETGLPPK EAAKQAMQEI TAPIIAITLV LLSVFVPVAF IPGITGALYA QFALTVSVAM
LISAINALTL SPALCGVFLK PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF
LSIVLVAGLG AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT
KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA EVNRRTAAIP
SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA QGLVMAANQN PKLSRVFTTF
ATDTPQLNLN IDRQKALSLG VSPNNIIQAL QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR
KTVEDIYRIN VRSSHGDMVP LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA
LAAMAQVSKT TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV
GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA KERREEGVPL
EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR RAVGTSVFGG MIAASAVGIF
LIPMLYVVLE RVREWGHARI LRKPLYEEEK QEKADGDASG PTVPPTQPED RGLS
