S35E2_HUMAN
ID S35E2_HUMAN Reviewed; 266 AA.
AC P0CK97; B3KWR0; O75035; Q2TAY8; Q569F8; Q5CZA4; Q5QPR8; Q9Y3J8;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Solute carrier family 35 member E2A {ECO:0000305};
GN Name=SLC35E2A {ECO:0000312|HGNC:HGNC:20863};
GN Synonyms=SLC35E2 {ECO:0000312|HGNC:HGNC:20863};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Rhodes S.;
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Choriocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- INTERACTION:
CC P0CK97; Q08AM2: ADAM33; NbExp=3; IntAct=EBI-18054851, EBI-10225815;
CC P0CK97; P60201-2: PLP1; NbExp=3; IntAct=EBI-18054851, EBI-12188331;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P0CK97-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P0CK97-2; Sequence=VSP_040665;
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
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DR EMBL; AL049665; CAB41241.1; -; mRNA.
DR EMBL; AL031282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062371; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC101666; AAI01667.1; -; mRNA.
DR EMBL; BC112289; AAI12290.1; -; mRNA.
DR RefSeq; NP_001186716.1; NM_001199787.1. [P0CK97-2]
DR RefSeq; NP_878258.1; NM_182838.2. [P0CK97-1]
DR AlphaFoldDB; P0CK97; -.
DR SMR; P0CK97; -.
DR BioGRID; 115235; 4.
DR IntAct; P0CK97; 2.
DR STRING; 9606.ENSP00000246421; -.
DR iPTMnet; P0CK97; -.
DR PhosphoSitePlus; P0CK97; -.
DR SwissPalm; P0CK97; -.
DR BioMuta; SLC35E2; -.
DR DMDM; 325530285; -.
DR jPOST; P0CK97; -.
DR MassIVE; P0CK97; -.
DR MaxQB; P0CK97; -.
DR PaxDb; P0CK97; -.
DR PeptideAtlas; P0CK97; -.
DR PRIDE; P0CK97; -.
DR TopDownProteomics; P0CK97-2; -. [P0CK97-2]
DR DNASU; 9906; -.
DR GeneID; 9906; -.
DR UCSC; uc001ahy.4; human. [P0CK97-1]
DR CTD; 9906; -.
DR GeneCards; SLC35E2A; -.
DR HGNC; HGNC:20863; SLC35E2A.
DR neXtProt; NX_P0CK97; -.
DR eggNOG; KOG1441; Eukaryota.
DR HOGENOM; CLU_019048_2_2_1; -.
DR InParanoid; P0CK97; -.
DR OrthoDB; 1104499at2759; -.
DR PhylomeDB; P0CK97; -.
DR TreeFam; TF331257; -.
DR PathwayCommons; P0CK97; -.
DR SignaLink; P0CK97; -.
DR BioGRID-ORCS; 9906; 17 hits in 1017 CRISPR screens.
DR ChiTaRS; SLC35E2A; human.
DR GenomeRNAi; 9906; -.
DR Pharos; P0CK97; Tdark.
DR PRO; PR:P0CK97; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P0CK97; protein.
DR Genevisible; P0CK97; HS.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..266
FT /note="Solute carrier family 35 member E2A"
FT /id="PRO_0000405314"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 245..266
FT /note="VPQALHRVALSMALPCPMLPAS -> AQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040665"
FT CONFLICT 204
FT /note="R -> W (in Ref. 3; BC062371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29079 MW; 16C1B2648C0322D5 CRC64;
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD ENVLTVTITE
TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL GGEPSMLGAV QMLSTTVIGC
VKTLVPCCLY QHKARLSYPP NFLMTMLFVG LMRFATVVLG LVSLKNVAVS FAETVKSSAP
IFTVIMSRMI LGEYTGRPSD REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP
GDFQVPQALH RVALSMALPC PMLPAS
