S35E2_MOUSE
ID S35E2_MOUSE Reviewed; 405 AA.
AC Q8C811;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Solute carrier family 35 member E2A {ECO:0000305};
GN Name=Slc35e2a; Synonyms=Slc35e2 {ECO:0000312|MGI:MGI:2444240};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Cerebellum, Mammary gland, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
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DR EMBL; AK048716; BAC33431.1; -; mRNA.
DR EMBL; AK145065; BAE26216.1; -; mRNA.
DR EMBL; AK157354; BAE34060.1; -; mRNA.
DR EMBL; AL627405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC058728; AAH58728.1; -; mRNA.
DR CCDS; CCDS38995.1; -.
DR RefSeq; NP_796160.1; NM_177186.4.
DR RefSeq; XP_006539015.1; XM_006538952.3.
DR RefSeq; XP_006539016.1; XM_006538953.3.
DR AlphaFoldDB; Q8C811; -.
DR SMR; Q8C811; -.
DR STRING; 10090.ENSMUSP00000101233; -.
DR iPTMnet; Q8C811; -.
DR PhosphoSitePlus; Q8C811; -.
DR MaxQB; Q8C811; -.
DR PaxDb; Q8C811; -.
DR PRIDE; Q8C811; -.
DR ProteomicsDB; 256558; -.
DR Antibodypedia; 62304; 51 antibodies from 14 providers.
DR DNASU; 320541; -.
DR Ensembl; ENSMUST00000043829; ENSMUSP00000041449; ENSMUSG00000042202.
DR Ensembl; ENSMUST00000105608; ENSMUSP00000101233; ENSMUSG00000042202.
DR Ensembl; ENSMUST00000118607; ENSMUSP00000113189; ENSMUSG00000042202.
DR GeneID; 320541; -.
DR KEGG; mmu:320541; -.
DR UCSC; uc008wdw.2; mouse.
DR CTD; 320541; -.
DR MGI; MGI:2444240; Slc35e2.
DR VEuPathDB; HostDB:ENSMUSG00000042202; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00940000159351; -.
DR HOGENOM; CLU_019048_2_0_1; -.
DR InParanoid; Q8C811; -.
DR OMA; VWNWRSL; -.
DR OrthoDB; 1104499at2759; -.
DR PhylomeDB; Q8C811; -.
DR TreeFam; TF331257; -.
DR BioGRID-ORCS; 320541; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q8C811; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8C811; protein.
DR Bgee; ENSMUSG00000042202; Expressed in manus and 217 other tissues.
DR Genevisible; Q8C811; MM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; IMP:MGI.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..405
FT /note="Solute carrier family 35 member E2A"
FT /id="PRO_0000305058"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 44279 MW; BBAE003CFF0189B0 CRC64;
MSAAAKSQVP EEAAPGCEEE PKGKTLLTWG SLFGHRSEKI VFTKGDGSPE ESLLTVTITE
TTVIESDLGV WSSRALIYLT LWFFFSFCTL FLNKYILSLL EGEPSMLGAV QMLSTTLIGC
VKIFVPCCLY QHKTRLSYPP NFIMTMLFVG LMRFATVVLG LVSLKNVAVS FAETVKSSAP
IFTVIMSRMI LGEYTGLLVN LSLIPVMGGL ALCTATEISF NILGFSAALS TNIMDCLQNV
FSKKLLSGDK YRFSAPELQF YTSAAAVALL IPAWTFFMDI PVIGRSGKSF SYSQDIVLLL
LTDGALFHLQ SVTAYALMGK ISPVTFSVAS TVKHALSIWL SIIVFGNKIT SLSAIGTILV
TLGVLLYNKA RQYQQETMQS LVTATSRNPE DDTEPLVPQD SRQHH
