S35E3_HUMAN
ID S35E3_HUMAN Reviewed; 313 AA.
AC Q7Z769; A8K0T0; Q0P5Y5; Q9P0V1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Solute carrier family 35 member E3;
DE AltName: Full=Bladder cancer-overexpressed gene 1 protein;
GN Name=SLC35E3; Synonyms=BLOV1; ORFNames=UNQ3043/PRO9859;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Luscombe M.J., Knowles M.A.;
RT "A novel gene which is overexpressed in advanced bladder cancer.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- INTERACTION:
CC Q7Z769; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-13389236, EBI-10827839;
CC Q7Z769; P27449: ATP6V0C; NbExp=3; IntAct=EBI-13389236, EBI-721179;
CC Q7Z769; Q92843: BCL2L2; NbExp=3; IntAct=EBI-13389236, EBI-707714;
CC Q7Z769; Q13323: BIK; NbExp=3; IntAct=EBI-13389236, EBI-700794;
CC Q7Z769; Q12982: BNIP2; NbExp=3; IntAct=EBI-13389236, EBI-752094;
CC Q7Z769; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-13389236, EBI-12003442;
CC Q7Z769; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-13389236, EBI-10267100;
CC Q7Z769; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-13389236, EBI-18304435;
CC Q7Z769; O15552: FFAR2; NbExp=3; IntAct=EBI-13389236, EBI-2833872;
CC Q7Z769; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-13389236, EBI-713304;
CC Q7Z769; O00258: GET1; NbExp=3; IntAct=EBI-13389236, EBI-18908258;
CC Q7Z769; O00155: GPR25; NbExp=3; IntAct=EBI-13389236, EBI-10178951;
CC Q7Z769; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-13389236, EBI-12133176;
CC Q7Z769; P60201-2: PLP1; NbExp=3; IntAct=EBI-13389236, EBI-12188331;
CC Q7Z769; Q99942: RNF5; NbExp=3; IntAct=EBI-13389236, EBI-348482;
CC Q7Z769; Q96GQ5: RUSF1; NbExp=3; IntAct=EBI-13389236, EBI-8636004;
CC Q7Z769; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-13389236, EBI-9679163;
CC Q7Z769; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-13389236, EBI-3907610;
CC Q7Z769; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-13389236, EBI-742688;
CC Q7Z769; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-13389236, EBI-17280858;
CC Q7Z769; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13389236, EBI-8638294;
CC Q7Z769; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-13389236, EBI-8642211;
CC Q7Z769; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-13389236, EBI-2852148;
CC Q7Z769; P49638: TTPA; NbExp=3; IntAct=EBI-13389236, EBI-10210710;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF73127.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF148713; AAF73127.1; ALT_FRAME; mRNA.
DR EMBL; AY358943; AAQ89302.1; -; mRNA.
DR EMBL; AK289645; BAF82334.1; -; mRNA.
DR EMBL; CH471054; EAW97196.1; -; Genomic_DNA.
DR EMBL; BC008412; AAH08412.1; -; mRNA.
DR EMBL; BC021103; AAH21103.1; -; mRNA.
DR EMBL; BC030504; AAH30504.1; -; mRNA.
DR EMBL; BC049192; AAH49192.1; -; mRNA.
DR CCDS; CCDS41808.1; -.
DR RefSeq; NP_061126.2; NM_018656.2.
DR AlphaFoldDB; Q7Z769; -.
DR SMR; Q7Z769; -.
DR BioGRID; 120688; 25.
DR IntAct; Q7Z769; 24.
DR STRING; 9606.ENSP00000381089; -.
DR TCDB; 2.A.7.9.15; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q7Z769; -.
DR PhosphoSitePlus; Q7Z769; -.
DR BioMuta; SLC35E3; -.
DR DMDM; 74738870; -.
DR EPD; Q7Z769; -.
DR MassIVE; Q7Z769; -.
DR PaxDb; Q7Z769; -.
DR PeptideAtlas; Q7Z769; -.
DR PRIDE; Q7Z769; -.
DR ProteomicsDB; 69488; -.
DR Antibodypedia; 59245; 13 antibodies from 8 providers.
DR DNASU; 55508; -.
DR Ensembl; ENST00000398004.4; ENSP00000381089.2; ENSG00000175782.11.
DR GeneID; 55508; -.
DR KEGG; hsa:55508; -.
DR MANE-Select; ENST00000398004.4; ENSP00000381089.2; NM_018656.5; NP_061126.2.
DR UCSC; uc001suh.4; human.
DR CTD; 55508; -.
DR DisGeNET; 55508; -.
DR GeneCards; SLC35E3; -.
DR HGNC; HGNC:20864; SLC35E3.
DR HPA; ENSG00000175782; Low tissue specificity.
DR neXtProt; NX_Q7Z769; -.
DR OpenTargets; ENSG00000175782; -.
DR PharmGKB; PA128394684; -.
DR VEuPathDB; HostDB:ENSG00000175782; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00730000111164; -.
DR HOGENOM; CLU_048347_3_2_1; -.
DR InParanoid; Q7Z769; -.
DR OMA; QGLGMLC; -.
DR OrthoDB; 938634at2759; -.
DR PhylomeDB; Q7Z769; -.
DR TreeFam; TF329429; -.
DR PathwayCommons; Q7Z769; -.
DR SignaLink; Q7Z769; -.
DR BioGRID-ORCS; 55508; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; SLC35E3; human.
DR GenomeRNAi; 55508; -.
DR Pharos; Q7Z769; Tdark.
DR PRO; PR:Q7Z769; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q7Z769; protein.
DR Bgee; ENSG00000175782; Expressed in endothelial cell and 184 other tissues.
DR ExpressionAtlas; Q7Z769; baseline and differential.
DR Genevisible; Q7Z769; HS.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Solute carrier family 35 member E3"
FT /id="PRO_0000297899"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 61
FT /note="C -> S (in Ref. 5; AAH49192)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="T -> A (in Ref. 1; AAF73127)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="G -> D (in Ref. 1; AAF73127)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35066 MW; 275821E8A9CBE263 CRC64;
MALLVDRVRG HWRIAAGLLF NLLVSICIVF LNKWIYVYHG FPNMSLTLVH FVVTWLGLYI
CQKLDIFAPK SLPPSRLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF
CYQKTFSTRI QLTLIPITLG VILNSYYDVK FNFLGMVFAA LGVLVTSLYQ VWVGAKQHEL
QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF GEGGIFGPWS VSALLMVLLS GVIAFMVNLS
IYWIIGNTSP VTYNMFGHFK FCITLFGGYV LFKDPLSINQ ALGILCTLFG ILAYTHFKLS
EQEGSRSKLA QRP
