ID   S35E3_MOUSE             Reviewed;         313 AA.
AC   Q6PGC7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Solute carrier family 35 member E3;
GN   Name=Slc35e3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC006601; AAH06601.1; -; mRNA.
DR   EMBL; BC057101; AAH57101.1; -; mRNA.
DR   CCDS; CCDS24195.1; -.
DR   RefSeq; NP_084151.2; NM_029875.2.
DR   AlphaFoldDB; Q6PGC7; -.
DR   SMR; Q6PGC7; -.
DR   STRING; 10090.ENSMUSP00000078050; -.
DR   TCDB; 2.A.7.9.10; the drug/metabolite transporter (dmt) superfamily.
DR   PhosphoSitePlus; Q6PGC7; -.
DR   PaxDb; Q6PGC7; -.
DR   PRIDE; Q6PGC7; -.
DR   ProteomicsDB; 256677; -.
DR   Antibodypedia; 59245; 13 antibodies from 8 providers.
DR   DNASU; 215436; -.
DR   Ensembl; ENSMUST00000079041; ENSMUSP00000078050; ENSMUSG00000060181.
DR   GeneID; 215436; -.
DR   KEGG; mmu:215436; -.
DR   UCSC; uc007hdn.1; mouse.
DR   CTD; 55508; -.
DR   MGI; MGI:2448489; Slc35e3.
DR   VEuPathDB; HostDB:ENSMUSG00000060181; -.
DR   eggNOG; KOG1441; Eukaryota.
DR   GeneTree; ENSGT00730000111164; -.
DR   HOGENOM; CLU_048347_3_2_1; -.
DR   InParanoid; Q6PGC7; -.
DR   OMA; QGLGMLC; -.
DR   OrthoDB; 938634at2759; -.
DR   PhylomeDB; Q6PGC7; -.
DR   TreeFam; TF329429; -.
DR   BioGRID-ORCS; 215436; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Slc35e3; mouse.
DR   PRO; PR:Q6PGC7; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q6PGC7; protein.
DR   Bgee; ENSMUSG00000060181; Expressed in humerus cartilage element and 251 other tissues.
DR   Genevisible; Q6PGC7; MM.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005338; F:nucleotide-sugar transmembrane transporter activity; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..313
FT                   /note="Solute carrier family 35 member E3"
FT                   /id="PRO_0000297900"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  34892 MW;  1B3B5DFD2E84FFF6 CRC64;
     MASLADRVRG NGRIAAGLLF NLLVSICIVF LNKWIYVHHG FPNMSLTLVH FVVTWLGLYI
     CQKLNIFAPK SLPLSKLLLL ALSFCGFVVF TNLSLQNNTI GTYQLAKAMT TPVIIAIQTF
     WYQKRFSVRI QLTLIPITVG VILNSYYDVK FHSLGMVFAA LGVVVTSLYQ VWVGAKQHEL
     QVNSMQLLYY QAPMSSAMLL VAVPFFEPVF AEGGIFGPWS VSALLMVLLS GIIAFMVNLS
     IYWIIGNTSP VTYNMFGHFK FCITLCGGYI LFKDPLSVNQ GLGILCTLFG ILTYTHFKLS
     EQEGSKSKLV QRP