S35E4_HUMAN
ID S35E4_HUMAN Reviewed; 350 AA.
AC Q6ICL7; Q567P0;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Solute carrier family 35 member E4;
GN Name=SLC35E4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ICL7; Q13520: AQP6; NbExp=3; IntAct=EBI-12867720, EBI-13059134;
CC Q6ICL7; P34972: CNR2; NbExp=3; IntAct=EBI-12867720, EBI-2835940;
CC Q6ICL7; Q96P66: GPR101; NbExp=3; IntAct=EBI-12867720, EBI-17935713;
CC Q6ICL7; O15529: GPR42; NbExp=3; IntAct=EBI-12867720, EBI-18076404;
CC Q6ICL7; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12867720, EBI-18053395;
CC Q6ICL7; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-12867720, EBI-6163737;
CC Q6ICL7; P15941-11: MUC1; NbExp=3; IntAct=EBI-12867720, EBI-17263240;
CC Q6ICL7; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12867720, EBI-17247926;
CC Q6ICL7; Q14973: SLC10A1; NbExp=3; IntAct=EBI-12867720, EBI-3923031;
CC Q6ICL7; Q9UKG4: SLC13A4; NbExp=3; IntAct=EBI-12867720, EBI-12808018;
CC Q6ICL7; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-12867720, EBI-6268651;
CC Q6ICL7; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12867720, EBI-8638294;
CC Q6ICL7; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12867720, EBI-10982110;
CC Q6ICL7; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-12867720, EBI-13356252;
CC Q6ICL7; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-12867720, EBI-1055364;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ICL7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ICL7-2; Sequence=VSP_027480, VSP_027481;
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
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DR EMBL; CR456351; CAG30237.1; -; mRNA.
DR EMBL; BC040191; AAH40191.1; -; mRNA.
DR EMBL; BC093099; AAH93099.1; -; mRNA.
DR EMBL; BC107119; AAI07120.1; -; mRNA.
DR CCDS; CCDS13882.1; -. [Q6ICL7-1]
DR CCDS; CCDS82708.1; -. [Q6ICL7-2]
DR RefSeq; NP_001001479.1; NM_001001479.3. [Q6ICL7-1]
DR RefSeq; NP_001305299.1; NM_001318370.1. [Q6ICL7-2]
DR RefSeq; NP_001305300.1; NM_001318371.1.
DR RefSeq; XP_016884283.1; XM_017028794.1. [Q6ICL7-1]
DR RefSeq; XP_016884284.1; XM_017028795.1. [Q6ICL7-1]
DR AlphaFoldDB; Q6ICL7; -.
DR SMR; Q6ICL7; -.
DR BioGRID; 130914; 17.
DR IntAct; Q6ICL7; 15.
DR STRING; 9606.ENSP00000339626; -.
DR TCDB; 2.A.7.9.11; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q6ICL7; -.
DR PhosphoSitePlus; Q6ICL7; -.
DR BioMuta; SLC35E4; -.
DR DMDM; 74748762; -.
DR jPOST; Q6ICL7; -.
DR MassIVE; Q6ICL7; -.
DR PaxDb; Q6ICL7; -.
DR PeptideAtlas; Q6ICL7; -.
DR PRIDE; Q6ICL7; -.
DR ProteomicsDB; 66400; -. [Q6ICL7-1]
DR Antibodypedia; 62513; 18 antibodies from 9 providers.
DR DNASU; 339665; -.
DR Ensembl; ENST00000343605.5; ENSP00000339626.4; ENSG00000100036.13. [Q6ICL7-1]
DR Ensembl; ENST00000406566.1; ENSP00000384377.1; ENSG00000100036.13. [Q6ICL7-2]
DR GeneID; 339665; -.
DR KEGG; hsa:339665; -.
DR MANE-Select; ENST00000343605.5; ENSP00000339626.4; NM_001001479.4; NP_001001479.1.
DR UCSC; uc003ais.2; human. [Q6ICL7-1]
DR CTD; 339665; -.
DR DisGeNET; 339665; -.
DR GeneCards; SLC35E4; -.
DR HGNC; HGNC:17058; SLC35E4.
DR HPA; ENSG00000100036; Tissue enhanced (testis).
DR neXtProt; NX_Q6ICL7; -.
DR OpenTargets; ENSG00000100036; -.
DR PharmGKB; PA134883803; -.
DR VEuPathDB; HostDB:ENSG00000100036; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00730000111291; -.
DR HOGENOM; CLU_022332_2_0_1; -.
DR InParanoid; Q6ICL7; -.
DR OMA; HWGARRP; -.
DR OrthoDB; 1018705at2759; -.
DR PhylomeDB; Q6ICL7; -.
DR TreeFam; TF328788; -.
DR PathwayCommons; Q6ICL7; -.
DR SignaLink; Q6ICL7; -.
DR BioGRID-ORCS; 339665; 12 hits in 1074 CRISPR screens.
DR ChiTaRS; SLC35E4; human.
DR GenomeRNAi; 339665; -.
DR Pharos; Q6ICL7; Tdark.
DR PRO; PR:Q6ICL7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ICL7; protein.
DR Bgee; ENSG00000100036; Expressed in left testis and 105 other tissues.
DR ExpressionAtlas; Q6ICL7; baseline and differential.
DR Genevisible; Q6ICL7; HS.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..350
FT /note="Solute carrier family 35 member E4"
FT /id="PRO_0000298927"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 125..179
FT /note="EamA"
FT REGION 19..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 208..234
FT /note="ALLQEERLDAVTLLYATSLPSFCLLAG -> LSFQICKMELMIPMERVRMRS
FT AGQGQE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027480"
FT VAR_SEQ 235..350
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027481"
SQ SEQUENCE 350 AA; 36747 MW; C725DD27F32728B1 CRC64;
MCRCPPEHHD GRMTSAEVGA AAGGAQAAGP PEWPPGSPQA LRQPGRARVA MAALVWLLAG
ASMSSLNKWI FTVHGFGRPL LLSALHMLVA ALACHRGARR PMPGGTRCRV LLLSLTFGTS
MACGNVGLRA VPLDLAQLVT TTTPLFTLAL SALLLGRRHH PLQLAAMGPL CLGAACSLAG
EFRTPPTGCG FLLAATCLRG LKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE
AGVAPPPTAG DSRLWACILL SCLLSVLYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
LLFGSRLSAL SYVGIALTLS GMFLYHNCEF VASWAARRGL WRRDQPSKGL
