S35E4_MOUSE
ID S35E4_MOUSE Reviewed; 351 AA.
AC Q8K3D6; Q5F205;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Solute carrier family 35 member E4;
GN Name=Slc35e4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK039786; BAC30453.1; -; mRNA.
DR EMBL; AL731853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020181; AAH20181.1; -; mRNA.
DR RefSeq; NP_694782.1; NM_153142.3.
DR AlphaFoldDB; Q8K3D6; -.
DR SMR; Q8K3D6; -.
DR STRING; 10090.ENSMUSP00000105622; -.
DR PhosphoSitePlus; Q8K3D6; -.
DR PaxDb; Q8K3D6; -.
DR PRIDE; Q8K3D6; -.
DR ProteomicsDB; 256559; -.
DR Antibodypedia; 62513; 18 antibodies from 9 providers.
DR DNASU; 103710; -.
DR Ensembl; ENSMUST00000109995; ENSMUSP00000105622; ENSMUSG00000048807.
DR GeneID; 103710; -.
DR KEGG; mmu:103710; -.
DR UCSC; uc007htv.1; mouse.
DR CTD; 339665; -.
DR MGI; MGI:2144150; Slc35e4.
DR VEuPathDB; HostDB:ENSMUSG00000048807; -.
DR eggNOG; KOG1441; Eukaryota.
DR GeneTree; ENSGT00730000111291; -.
DR HOGENOM; CLU_022332_2_0_1; -.
DR InParanoid; Q8K3D6; -.
DR OrthoDB; 1018705at2759; -.
DR PhylomeDB; Q8K3D6; -.
DR TreeFam; TF328788; -.
DR BioGRID-ORCS; 103710; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Slc35e4; mouse.
DR PRO; PR:Q8K3D6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8K3D6; protein.
DR Bgee; ENSMUSG00000048807; Expressed in gastrula and 204 other tissues.
DR ExpressionAtlas; Q8K3D6; baseline and differential.
DR Genevisible; Q8K3D6; MM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..351
FT /note="Solute carrier family 35 member E4"
FT /id="PRO_0000298928"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 125..179
FT /note="EamA"
FT CONFLICT 208
FT /note="Missing (in Ref. 1; BAC30453 and 3; AAH20181)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 37253 MW; D1CCE2DF8DA36A44 CRC64;
MCRCPLEHHE GMMTSAEAVA VAGSAQEHGR PKWPPDKPQV LGQPAPARVV VAALVWLLAG
ASMSSLNKWI FTVHGFGRPL LLSALHMLAA ALACHWGAQR PVPHSIHRRV LLLSLTFGTS
MACGNVGLST VPLDLAQLAT TTTPLFTMAL SALLLGRRHH PLQFAAMGPL CLGAACSLAG
ELRAPPAGCG FLLVATCLRG FKSVQQSGAL LQEERLDTVT LLYATSLPSF CLLASAALVL
EAGTAPPLPP TDSRLWACVL LSCFLSVVYN LASFSLLALT SALTVHVLGN LMVVGNLILS
RLLFGSHLSA LSYLGITLTL SGMFLYHNCE LVASWATRWG LWNRDQPGKG L
