ID   S35E4_RAT               Reviewed;         350 AA.
AC   Q5RKL7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Solute carrier family 35 member E4;
GN   Name=Slc35e4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC085693; AAH85693.1; -; mRNA.
DR   RefSeq; NP_695228.2; NM_153316.2.
DR   AlphaFoldDB; Q5RKL7; -.
DR   SMR; Q5RKL7; -.
DR   STRING; 10116.ENSRNOP00000005646; -.
DR   PaxDb; Q5RKL7; -.
DR   Ensembl; ENSRNOT00000005646; ENSRNOP00000005646; ENSRNOG00000004168.
DR   GeneID; 266687; -.
DR   KEGG; rno:266687; -.
DR   UCSC; RGD:708484; rat.
DR   CTD; 339665; -.
DR   RGD; 708484; Slc35e4.
DR   eggNOG; KOG1441; Eukaryota.
DR   GeneTree; ENSGT00730000111291; -.
DR   HOGENOM; CLU_022332_2_0_1; -.
DR   InParanoid; Q5RKL7; -.
DR   OMA; HWGARRP; -.
DR   OrthoDB; 1018705at2759; -.
DR   PhylomeDB; Q5RKL7; -.
DR   TreeFam; TF328788; -.
DR   PRO; PR:Q5RKL7; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000004168; Expressed in esophagus and 20 other tissues.
DR   ExpressionAtlas; Q5RKL7; baseline and differential.
DR   Genevisible; Q5RKL7; RN.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   Pfam; PF03151; TPT; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..350
FT                   /note="Solute carrier family 35 member E4"
FT                   /id="PRO_0000298929"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          125..179
FT                   /note="EamA"
SQ   SEQUENCE   350 AA;  37041 MW;  5905059BD4D90402 CRC64;
     MCRCPLEHHE VRMTSAEAIA VAGSAQEHGR PKWPPDKPQV LGQPALARVV VAALVWLLAG
     ASMSSLNKWI FTVHGFGRPL LLSALHMLAA AVACHWGAQR PVPHSIHRRV LLLSLTFGTS
     MACGNVGLST VPLDLAQLAT TTTPLFTLAL SALLLGRRHH PLQFAAMGPL CLGAACSLAG
     ELRAPPAGCG FLLVATCLRG FKSVQQSALL QEERLDAVTL LYATSLPSFC LLAGAALVLE
     AGAAPPLPPT DSRLWACVLL SCFLSVVYNL ASFSLLALTS ALTVHVLGNL TVVGNLILSR
     LLFGSHLSAL SYVGIALTLS GMFLYHNCES VASWATRRGL WNRDQPGKGL