S35F1_HUMAN
ID S35F1_HUMAN Reviewed; 408 AA.
AC Q5T1Q4; B4DJ02; E1P564; Q1RMG1; Q4G0U9; Q4G167; Q6N007;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Solute carrier family 35 member F1;
GN Name=SLC35F1; Synonyms=C6orf169;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408 (ISOFORM 1/2).
RC TISSUE=Cerebellum;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: Putative solute transporter. {ECO:0000305}.
CC -!- INTERACTION:
CC Q5T1Q4; Q13520: AQP6; NbExp=3; IntAct=EBI-13365456, EBI-13059134;
CC Q5T1Q4; P21964: COMT; NbExp=3; IntAct=EBI-13365456, EBI-372265;
CC Q5T1Q4; P36382: GJA5; NbExp=3; IntAct=EBI-13365456, EBI-750433;
CC Q5T1Q4; P48165: GJA8; NbExp=3; IntAct=EBI-13365456, EBI-17458373;
CC Q5T1Q4; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-13365456, EBI-17295964;
CC Q5T1Q4; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13365456, EBI-8638294;
CC Q5T1Q4; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-13365456, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T1Q4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T1Q4-2; Sequence=VSP_057263;
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH36493.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK295860; BAG58664.1; -; mRNA.
DR EMBL; AL449196; CAI16177.2; -; Genomic_DNA.
DR EMBL; AL133379; CAI16177.2; JOINED; Genomic_DNA.
DR EMBL; AL136478; CAI16177.2; JOINED; Genomic_DNA.
DR EMBL; Z95326; CAI16177.2; JOINED; Genomic_DNA.
DR EMBL; AL450405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48199.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48200.1; -; Genomic_DNA.
DR EMBL; BC028615; AAH28615.1; -; mRNA.
DR EMBL; BC036493; AAH36493.1; ALT_FRAME; mRNA.
DR EMBL; BC114925; AAI14926.1; -; mRNA.
DR EMBL; BX640761; CAE45867.1; -; mRNA.
DR CCDS; CCDS34524.1; -. [Q5T1Q4-1]
DR RefSeq; NP_001025029.2; NM_001029858.3. [Q5T1Q4-1]
DR RefSeq; XP_005266922.1; XM_005266865.4. [Q5T1Q4-1]
DR AlphaFoldDB; Q5T1Q4; -.
DR SMR; Q5T1Q4; -.
DR BioGRID; 128804; 20.
DR IntAct; Q5T1Q4; 12.
DR STRING; 9606.ENSP00000353557; -.
DR TCDB; 2.A.7.24.9; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q5T1Q4; -.
DR PhosphoSitePlus; Q5T1Q4; -.
DR BioMuta; SLC35F1; -.
DR DMDM; 160177559; -.
DR EPD; Q5T1Q4; -.
DR MassIVE; Q5T1Q4; -.
DR PaxDb; Q5T1Q4; -.
DR PeptideAtlas; Q5T1Q4; -.
DR PRIDE; Q5T1Q4; -.
DR ProteomicsDB; 64281; -. [Q5T1Q4-1]
DR Antibodypedia; 19478; 31 antibodies from 14 providers.
DR DNASU; 222553; -.
DR Ensembl; ENST00000360388.9; ENSP00000353557.4; ENSG00000196376.11. [Q5T1Q4-1]
DR Ensembl; ENST00000621341.1; ENSP00000484738.1; ENSG00000196376.11. [Q5T1Q4-2]
DR GeneID; 222553; -.
DR KEGG; hsa:222553; -.
DR MANE-Select; ENST00000360388.9; ENSP00000353557.4; NM_001029858.4; NP_001025029.2.
DR UCSC; uc003pxx.4; human. [Q5T1Q4-1]
DR CTD; 222553; -.
DR DisGeNET; 222553; -.
DR GeneCards; SLC35F1; -.
DR HGNC; HGNC:21483; SLC35F1.
DR HPA; ENSG00000196376; Group enriched (brain, retina).
DR neXtProt; NX_Q5T1Q4; -.
DR OpenTargets; ENSG00000196376; -.
DR PharmGKB; PA134985447; -.
DR VEuPathDB; HostDB:ENSG00000196376; -.
DR eggNOG; KOG2766; Eukaryota.
DR GeneTree; ENSGT00390000015655; -.
DR HOGENOM; CLU_039639_0_0_1; -.
DR InParanoid; Q5T1Q4; -.
DR OMA; VYIGLIC; -.
DR OrthoDB; 659967at2759; -.
DR PhylomeDB; Q5T1Q4; -.
DR TreeFam; TF313645; -.
DR PathwayCommons; Q5T1Q4; -.
DR SignaLink; Q5T1Q4; -.
DR BioGRID-ORCS; 222553; 7 hits in 1061 CRISPR screens.
DR ChiTaRS; SLC35F1; human.
DR GenomeRNAi; 222553; -.
DR Pharos; Q5T1Q4; Tdark.
DR PRO; PR:Q5T1Q4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T1Q4; protein.
DR Bgee; ENSG00000196376; Expressed in ventricular zone and 138 other tissues.
DR Genevisible; Q5T1Q4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR009262; SLC35_F1/F2/F6.
DR Pfam; PF06027; SLC35F; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="Solute carrier family 35 member F1"
FT /id="PRO_0000307307"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..59
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057263"
FT CONFLICT 11..13
FT /note="LQP -> AER (in Ref. 4; AAH36493)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="R -> G (in Ref. 4; AAH36493)"
FT /evidence="ECO:0000305"
FT CONFLICT 154
FT /note="T -> N (in Ref. 4; AAH28615)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="P -> Q (in Ref. 4; AAH28615)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 408 AA; 45346 MW; 2E459610FC84ECD8 CRC64;
MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ RIRKVLNREM
LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN YILLFLVYTT TLAVRQGEEN
LLAILRRRWW KYMILGLIDL EANYLVVKAY QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR
YKAVHFIGIV VCILGMGCMV GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI
IRTLSRVEFL GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL VLYSSTSTYI
AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE EEPHVRVA
