ID   BEPR_BRUSU              Reviewed;         209 AA.
AC   Q8G2M8; G0K646;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=HTH-type transcriptional repressor BepR;
GN   Name=bepR; OrderedLocusNames=BR0290, BS1330_I0291;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
RN   [3]
RP   FUNCTION AS A REPRESSOR.
RC   STRAIN=1330;
RX   PubMed=19201794; DOI=10.1128/jb.01198-08;
RA   Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D.,
RA   Zorreguieta A.;
RT   "Interplay between two RND systems mediating antimicrobial resistance in
RT   Brucella suis.";
RL   J. Bacteriol. 191:2530-2540(2009).
CC   -!- FUNCTION: Represses expression of bepDE. {ECO:0000269|PubMed:19201794}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014291; AAN29239.1; -; Genomic_DNA.
DR   EMBL; CP002997; AEM17652.1; -; Genomic_DNA.
DR   RefSeq; WP_004687968.1; NZ_KN046804.1.
DR   AlphaFoldDB; Q8G2M8; -.
DR   SMR; Q8G2M8; -.
DR   EnsemblBacteria; AEM17652; AEM17652; BS1330_I0291.
DR   GeneID; 45123796; -.
DR   GeneID; 55590069; -.
DR   KEGG; bms:BR0290; -.
DR   KEGG; bsi:BS1330_I0291; -.
DR   PATRIC; fig|204722.21.peg.1776; -.
DR   HOGENOM; CLU_069356_12_3_5; -.
DR   OMA; MMEIIFH; -.
DR   PhylomeDB; Q8G2M8; -.
DR   Proteomes; UP000007104; Chromosome I.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR013572; Tscrpt_reg_MAATS_C.
DR   Pfam; PF08361; TetR_C_2; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..209
FT                   /note="HTH-type transcriptional repressor BepR"
FT                   /id="PRO_0000390652"
FT   DOMAIN          9..69
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   209 AA;  23478 MW;  0649CBE216984B3A CRC64;
     MRRTKAEAAE TREAILLAAE QVFLERGVNQ STLTEIACYA GVTRGAIYFH FEDKLDIFQS
     IIGRARFPQE EIMLQAARFD HPNPLHILEQ SIVAALELFA TDERQQVVFT IINQRCEYVG
     EMAPVIDRLK EMRSDVLALF IGLLKVAERR GELASEWSAE TAAQILLAMV GGFLNEWLHG
     EKGFDLIIHG SRVISTVIQS LRAPANIPQ