S35F2_MOUSE
ID S35F2_MOUSE Reviewed; 375 AA.
AC Q7TML3; Q9DB62;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Solute carrier family 35 member F2;
GN Name=Slc35f2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-28, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Putative solute transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AK005182; BAB23867.1; -; mRNA.
DR EMBL; BC055843; AAH55843.1; -; mRNA.
DR CCDS; CCDS40639.1; -.
DR RefSeq; NP_082336.3; NM_028060.3.
DR AlphaFoldDB; Q7TML3; -.
DR SMR; Q7TML3; -.
DR STRING; 10090.ENSMUSP00000046528; -.
DR iPTMnet; Q7TML3; -.
DR PhosphoSitePlus; Q7TML3; -.
DR EPD; Q7TML3; -.
DR jPOST; Q7TML3; -.
DR MaxQB; Q7TML3; -.
DR PaxDb; Q7TML3; -.
DR PeptideAtlas; Q7TML3; -.
DR PRIDE; Q7TML3; -.
DR ProteomicsDB; 256679; -.
DR Antibodypedia; 31913; 70 antibodies from 19 providers.
DR DNASU; 72022; -.
DR Ensembl; ENSMUST00000048670; ENSMUSP00000046528; ENSMUSG00000042195.
DR GeneID; 72022; -.
DR KEGG; mmu:72022; -.
DR UCSC; uc009pmn.2; mouse.
DR CTD; 54733; -.
DR MGI; MGI:1919272; Slc35f2.
DR VEuPathDB; HostDB:ENSMUSG00000042195; -.
DR eggNOG; KOG2766; Eukaryota.
DR GeneTree; ENSGT00390000015655; -.
DR HOGENOM; CLU_039639_0_0_1; -.
DR InParanoid; Q7TML3; -.
DR OMA; MILSWWV; -.
DR OrthoDB; 659967at2759; -.
DR PhylomeDB; Q7TML3; -.
DR TreeFam; TF313645; -.
DR BioGRID-ORCS; 72022; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Slc35f2; mouse.
DR PRO; PR:Q7TML3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q7TML3; protein.
DR Bgee; ENSMUSG00000042195; Expressed in jejunum and 157 other tissues.
DR Genevisible; Q7TML3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR009262; SLC35_F1/F2/F6.
DR Pfam; PF06027; SLC35F; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..375
FT /note="Solute carrier family 35 member F2"
FT /id="PRO_0000307310"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8IXU6"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IXU6"
FT MOD_RES 22
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 28
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 372
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IXU6"
FT CONFLICT 89
FT /note="L -> V (in Ref. 2; AAH55843)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="R -> G (in Ref. 1; BAB23867)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 41635 MW; 09479EF60C99CBF6 CRC64;
MEAESPASAG ASEPRALGTV DSIGSQLSRI RRKLFTWDIL KTIALGQMLS LCICGTAITS
QYLAEKYRVN TPMLQSFINY CLLFLVYTLM LAFQSGSDNL LEILRRKWWK YTLLGLADVE
ANYLIVRAYQ YTTLTSVQLL DCFGIPVLMA LSWFILRARY KVIHFIAVFV CLLGVGTMVG
ADILAGREDN SGSDVLIGDI LVLLGASLYA VSNVCEEYIV KKLSRQEFLG MVGLFGTIIS
GIQLLIVEYK DIARIQWDWK IALLFVAFAL CMFCLYSFMP LVIKVTSATS VNLGILTADL
YSLFFGLFLF EYKFSGLYIL SFTVIMVGFI LYCSTPTRTV EPPESSVPPV TSIGIDNLGL
KLEESGLPET HSAVL
