S35F3_MOUSE
ID S35F3_MOUSE Reviewed; 421 AA.
AC Q1LZI2; Q8BL51;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Putative thiamine transporter SLC35F3 {ECO:0000250|UniProtKB:Q8IY50};
DE AltName: Full=Solute carrier family 35 member F3;
GN Name=Slc35f3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a thiamine transporter.
CC {ECO:0000250|UniProtKB:Q8IY50}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AK046359; BAC32690.1; -; mRNA.
DR EMBL; BC115859; AAI15860.1; -; mRNA.
DR EMBL; BC115965; AAI15966.1; -; mRNA.
DR CCDS; CCDS40520.1; -.
DR RefSeq; NP_780643.2; NM_175434.3.
DR AlphaFoldDB; Q1LZI2; -.
DR STRING; 10090.ENSMUSP00000104390; -.
DR iPTMnet; Q1LZI2; -.
DR PhosphoSitePlus; Q1LZI2; -.
DR PaxDb; Q1LZI2; -.
DR PRIDE; Q1LZI2; -.
DR ProteomicsDB; 256680; -.
DR Antibodypedia; 34691; 44 antibodies from 16 providers.
DR DNASU; 210027; -.
DR Ensembl; ENSMUST00000108759; ENSMUSP00000104390; ENSMUSG00000057060.
DR GeneID; 210027; -.
DR KEGG; mmu:210027; -.
DR UCSC; uc009nys.1; mouse.
DR CTD; 148641; -.
DR MGI; MGI:2444426; Slc35f3.
DR VEuPathDB; HostDB:ENSMUSG00000057060; -.
DR eggNOG; KOG4314; Eukaryota.
DR GeneTree; ENSGT00390000008727; -.
DR HOGENOM; CLU_022280_0_1_1; -.
DR InParanoid; Q1LZI2; -.
DR OMA; MCKSPER; -.
DR OrthoDB; 639186at2759; -.
DR PhylomeDB; Q1LZI2; -.
DR TreeFam; TF313798; -.
DR BioGRID-ORCS; 210027; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Slc35f3; mouse.
DR PRO; PR:Q1LZI2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q1LZI2; protein.
DR Bgee; ENSMUSG00000057060; Expressed in epithelium of lens and 98 other tissues.
DR ExpressionAtlas; Q1LZI2; baseline and differential.
DR Genevisible; Q1LZI2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015888; P:thiamine transport; ISO:MGI.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR026505; Solute_c_fam_35_mem_F3/F4.
DR PANTHER; PTHR19346; PTHR19346; 1.
DR Pfam; PF00892; EamA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..421
FT /note="Putative thiamine transporter SLC35F3"
FT /id="PRO_0000307880"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 25..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 86..109
FT /note="LARLTFKTFDAPFTLTWFATNWNF -> ARQADFQDLRRTVHPDVVCHQLEL
FT (in Ref. 1; BAC32690)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="K -> R (in Ref. 1; BAC32690)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 421 AA; 46924 MW; 40259CC972850054 CRC64;
MKKHSARVAP LSACNSPVLT LTKVEGEERP REPPGPAEAQ APAGTEAGGR TSRHNWTCSQ
ERLKKVFWGV AVVFCVCASW AGSTQLARLT FKTFDAPFTL TWFATNWNFL FFPLYYAGHV
CKSTEKQSMK QRYRECCRFF GDNGLTLKVF FTKAAPFGVL WTLTNYLYLH AIKKINATDV
SVLFCCNKSF VFLLSWIVLR DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVG
SASMSALYKV LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPVILYFTR VEYWNSFDDI
PWGNLCGFSI LLLTFNIVLN FGIAVTYPTL MSLGIVLSVP VNAVVDHYTS QIVFNGVRVI
AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEETAES SGDLGTGPQS RSRRARPSFA
R
