S35F4_HUMAN
ID S35F4_HUMAN Reviewed; 521 AA.
AC A4IF30; A6NDQ3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Solute carrier family 35 member F4;
GN Name=SLC35F4; Synonyms=C14orf36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative solute transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A4IF30-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4IF30-2; Sequence=VSP_029669;
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AL136520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101318; AAI01319.1; -; mRNA.
DR EMBL; BC101320; AAI01321.1; -; mRNA.
DR EMBL; BC101321; AAI01322.1; -; mRNA.
DR CCDS; CCDS86392.1; -. [A4IF30-2]
DR RefSeq; NP_001193849.1; NM_001206920.1.
DR RefSeq; NP_001293016.1; NM_001306087.1.
DR RefSeq; XP_011535027.1; XM_011536725.1.
DR RefSeq; XP_016876749.1; XM_017021260.1. [A4IF30-2]
DR AlphaFoldDB; A4IF30; -.
DR IntAct; A4IF30; 1.
DR STRING; 9606.ENSP00000342518; -.
DR TCDB; 2.A.7.24.14; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; A4IF30; -.
DR PhosphoSitePlus; A4IF30; -.
DR BioMuta; SLC35F4; -.
DR PaxDb; A4IF30; -.
DR PeptideAtlas; A4IF30; -.
DR PRIDE; A4IF30; -.
DR Antibodypedia; 50928; 24 antibodies from 9 providers.
DR DNASU; 341880; -.
DR Ensembl; ENST00000339762.10; ENSP00000342518.6; ENSG00000151812.15. [A4IF30-1]
DR Ensembl; ENST00000554729.5; ENSP00000451990.1; ENSG00000151812.15. [A4IF30-2]
DR GeneID; 341880; -.
DR KEGG; hsa:341880; -.
DR UCSC; uc010apa.2; human. [A4IF30-1]
DR CTD; 341880; -.
DR DisGeNET; 341880; -.
DR GeneCards; SLC35F4; -.
DR HGNC; HGNC:19845; SLC35F4.
DR HPA; ENSG00000151812; Tissue enhanced (brain, retina, seminal vesicle).
DR neXtProt; NX_A4IF30; -.
DR OpenTargets; ENSG00000151812; -.
DR PharmGKB; PA134959551; -.
DR VEuPathDB; HostDB:ENSG00000151812; -.
DR eggNOG; KOG4314; Eukaryota.
DR GeneTree; ENSGT00390000008727; -.
DR HOGENOM; CLU_022280_0_1_1; -.
DR InParanoid; A4IF30; -.
DR OrthoDB; 639186at2759; -.
DR PhylomeDB; A4IF30; -.
DR TreeFam; TF313798; -.
DR PathwayCommons; A4IF30; -.
DR BioGRID-ORCS; 341880; 2 hits in 246 CRISPR screens.
DR ChiTaRS; SLC35F4; human.
DR GenomeRNAi; 341880; -.
DR Pharos; A4IF30; Tdark.
DR PRO; PR:A4IF30; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; A4IF30; protein.
DR Bgee; ENSG00000151812; Expressed in cerebellar hemisphere and 99 other tissues.
DR ExpressionAtlas; A4IF30; baseline and differential.
DR Genevisible; A4IF30; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR009262; SLC35_F1/F2/F6.
DR InterPro; IPR026505; Solute_c_fam_35_mem_F3/F4.
DR PANTHER; PTHR19346; PTHR19346; 1.
DR Pfam; PF06027; SLC35F; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..521
FT /note="Solute carrier family 35 member F4"
FT /id="PRO_0000311965"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 261..321
FT /note="EamA"
FT VAR_SEQ 1..159
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029669"
SQ SEQUENCE 521 AA; 57809 MW; 8509C6BAB218E5B8 CRC64;
MDELLLDLFH KLTSGRQLAA GNGLCGISHK EQEVWKPGHN ILVKMRKEDK SLVWLIHSTL
ARYTQVTNFL GTSRSSVTRC KPGANCPSSH SGISRQLSPL SVTEDSSAPI LELQNQGSSG
VCGHRVERQN RSADDGTQTH SENSSQENRI KARCLSCTSM VLKGIWGLLI ILSVSSSWVG
TTQIVKITYK NFYCPFFMTW FSTNWNIMFF PVYYSGHLAT AQEKQSPMKK FRECSRIFGE
DGLTLKLFLK RTAPFSILWT LTNYLYLLAL KKLTATDVSA LFCCNKAFVF LLSWIVLKDR
FMGVRIVAAI MAITGIVMMA YADNFHADSI IGVAFAVGSA STSALYKVLF KMFLGSANFG
EAAHFVSTLG FFNLIFISFT PVILYFTKVE HWSSFAALPW GCLCGMAGLW LAFNILVNVG
VVLTYPILIS IGTVLSVPGN AAVDLLKQEV IFNVVRLAAT IIICIGFLLM LLPEEWDEIT
LRFINSLKEK KSEEHVDDVT DPSIHLRGRG RANGTVSIPL A
