S35F4_MOUSE
ID S35F4_MOUSE Reviewed; 485 AA.
AC Q8BZK4; B8JJY8; Q8BL81; Q8BXC4; Q9JJG8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Solute carrier family 35 member F4;
GN Name=Slc35f4; ORFNames=MNCb-0335;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Diencephalon, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative solute transporter. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8BZK4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZK4-2; Sequence=VSP_029670, VSP_029671;
CC Name=3;
CC IsoId=Q8BZK4-3; Sequence=VSP_029672, VSP_029673;
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AB041538; BAA95023.1; -; mRNA.
DR EMBL; AK034308; BAC28670.1; -; mRNA.
DR EMBL; AK046093; BAC32602.1; -; mRNA.
DR EMBL; AK047949; BAC33198.1; -; mRNA.
DR EMBL; AC154316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT030637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC145720; AAI45721.1; -; mRNA.
DR CCDS; CCDS26997.1; -. [Q8BZK4-1]
DR RefSeq; NP_083514.1; NM_029238.2. [Q8BZK4-1]
DR AlphaFoldDB; Q8BZK4; -.
DR STRING; 10090.ENSMUSP00000073972; -.
DR PhosphoSitePlus; Q8BZK4; -.
DR PaxDb; Q8BZK4; -.
DR PRIDE; Q8BZK4; -.
DR ProteomicsDB; 256560; -. [Q8BZK4-1]
DR ProteomicsDB; 256561; -. [Q8BZK4-2]
DR ProteomicsDB; 256562; -. [Q8BZK4-3]
DR Antibodypedia; 50928; 24 antibodies from 9 providers.
DR DNASU; 75288; -.
DR Ensembl; ENSMUST00000074368; ENSMUSP00000073972; ENSMUSG00000021852. [Q8BZK4-1]
DR Ensembl; ENSMUST00000123534; ENSMUSP00000122405; ENSMUSG00000021852. [Q8BZK4-3]
DR Ensembl; ENSMUST00000138884; ENSMUSP00000119007; ENSMUSG00000021852. [Q8BZK4-2]
DR GeneID; 75288; -.
DR KEGG; mmu:75288; -.
DR UCSC; uc007tkf.1; mouse. [Q8BZK4-1]
DR UCSC; uc007tkg.1; mouse. [Q8BZK4-3]
DR UCSC; uc011zjs.1; mouse. [Q8BZK4-2]
DR CTD; 341880; -.
DR MGI; MGI:1922538; Slc35f4.
DR VEuPathDB; HostDB:ENSMUSG00000021852; -.
DR eggNOG; KOG4314; Eukaryota.
DR GeneTree; ENSGT00390000008727; -.
DR HOGENOM; CLU_022280_1_0_1; -.
DR InParanoid; Q8BZK4; -.
DR OMA; YSGHVVT; -.
DR PhylomeDB; Q8BZK4; -.
DR TreeFam; TF313798; -.
DR BioGRID-ORCS; 75288; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc35f4; mouse.
DR PRO; PR:Q8BZK4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BZK4; protein.
DR Bgee; ENSMUSG00000021852; Expressed in barrel cortex and 53 other tissues.
DR ExpressionAtlas; Q8BZK4; baseline and differential.
DR Genevisible; Q8BZK4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR009262; SLC35_F1/F2/F6.
DR InterPro; IPR026505; Solute_c_fam_35_mem_F3/F4.
DR PANTHER; PTHR19346; PTHR19346; 1.
DR Pfam; PF06027; SLC35F; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..485
FT /note="Solute carrier family 35 member F4"
FT /id="PRO_0000311966"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 225..285
FT /note="EamA"
FT REGION 32..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029670"
FT VAR_SEQ 151..175
FT /note="ITYKNFYCPFFMTWFSTNWNIMFFP -> MPVLHIHGSEDHLGTLDHLVSVI
FT IL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_029671"
FT VAR_SEQ 270..313
FT /note="IVAAIMAITGIVMMAYADNFHADSIIGVAFAVGSASTSALYKVL -> VMAH
FT LIPCAVPPCFLNLITALLFPGVSLKLAPLVLSTNCNWKMC (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029672"
FT VAR_SEQ 314..485
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029673"
FT CONFLICT 268
FT /note="V -> M (in Ref. 2; BAC32602)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 53704 MW; DD0107EFC5E0E0A1 CRC64;
MDVKAAPNGV ATIEDRILRI TGYYGYYPGY SSQKSTTRSS VTRCKPGPNC PSSHSSISRQ
LSPLSVTEDS SAPILELQSR GSSGVCGRRV ERQSRSGDDG TQTRPESSSQ ENGLKARCLS
CTSMVLKTIW GLLIILSVSS SWVGTTQIVK ITYKNFYCPF FMTWFSTNWN IMFFPVYYSG
HLATAQEKQS PIKKFRECSR IFGEDGLTLK LFLKRTAPFS ILWTLTNYLY LLALKKLTAT
DVSALFCCNK AFVFLLSWIV LKDRFMGVRI VAAIMAITGI VMMAYADNFH ADSIIGVAFA
VGSASTSALY KVLFKMFLGS ANFGEAAHFV STLGFFNLIF ISFTPIILYF TKVEHWSSFA
ALPWGCLCGM AGLWLAFNIL VNVGVVLTYP ILISIGTVLS VPGNAAVDLL KQEVIFNVVR
LAATIIICIG FLLMLLPEEW DEITLRFINS LKEKKSEEHV EDLTDVSVHL RSRSRVNGTV
SIPLA
