S35F6_MOUSE
ID S35F6_MOUSE Reviewed; 372 AA.
AC Q8VE96; Q3UB33; Q8BKN1; Q9D5B2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Solute carrier family 35 member F6;
DE AltName: Full=ANT2-binding protein;
DE Short=ANT2BP;
DE AltName: Full=Transport and Golgi organization 9 homolog;
DE Flags: Precursor;
GN Name=Slc35f6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Amnion, Bone marrow, Embryo, Kidney, Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the maintenance of mitochondrial membrane
CC potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes
CC pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as
CC a nucleotide-sugar transporter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SLC25A5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Lysosome membrane
CC {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29891.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK015555; BAB29891.1; ALT_FRAME; mRNA.
DR EMBL; AK049408; BAC33740.1; -; mRNA.
DR EMBL; AK051359; BAC34613.1; -; mRNA.
DR EMBL; AK149968; BAE29202.1; -; mRNA.
DR EMBL; AK151122; BAE30131.1; -; mRNA.
DR EMBL; AK159707; BAE35306.1; -; mRNA.
DR EMBL; AK169121; BAE40901.1; -; mRNA.
DR EMBL; AK169163; BAE40942.1; -; mRNA.
DR EMBL; BC019457; AAH19457.1; -; mRNA.
DR CCDS; CCDS19161.1; -.
DR RefSeq; NP_783606.2; NM_175675.3.
DR AlphaFoldDB; Q8VE96; -.
DR SMR; Q8VE96; -.
DR STRING; 10090.ENSMUSP00000058680; -.
DR GlyGen; Q8VE96; 1 site.
DR iPTMnet; Q8VE96; -.
DR PhosphoSitePlus; Q8VE96; -.
DR SwissPalm; Q8VE96; -.
DR jPOST; Q8VE96; -.
DR MaxQB; Q8VE96; -.
DR PaxDb; Q8VE96; -.
DR PeptideAtlas; Q8VE96; -.
DR PRIDE; Q8VE96; -.
DR ProteomicsDB; 256564; -.
DR Antibodypedia; 28001; 135 antibodies from 21 providers.
DR Ensembl; ENSMUST00000062962; ENSMUSP00000058680; ENSMUSG00000029175.
DR GeneID; 74919; -.
DR KEGG; mmu:74919; -.
DR UCSC; uc008wvs.2; mouse.
DR CTD; 54978; -.
DR MGI; MGI:1922169; Slc35f6.
DR VEuPathDB; HostDB:ENSMUSG00000029175; -.
DR eggNOG; KOG3912; Eukaryota.
DR GeneTree; ENSGT00390000017237; -.
DR HOGENOM; CLU_025028_1_0_1; -.
DR InParanoid; Q8VE96; -.
DR OMA; LWSKWQD; -.
DR OrthoDB; 1169953at2759; -.
DR PhylomeDB; Q8VE96; -.
DR TreeFam; TF105890; -.
DR BioGRID-ORCS; 74919; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Slc35f6; mouse.
DR PRO; PR:Q8VE96; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8VE96; protein.
DR Bgee; ENSMUSG00000029175; Expressed in interventricular septum and 235 other tissues.
DR ExpressionAtlas; Q8VE96; baseline and differential.
DR Genevisible; Q8VE96; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR GO; GO:0005764; C:lysosome; IDA:MGI.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR InterPro; IPR009262; SLC35_F1/F2/F6.
DR InterPro; IPR012404; UCP036436.
DR Pfam; PF06027; SLC35F; 1.
DR PIRSF; PIRSF036436; UCP036436; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Lysosome; Membrane; Mitochondrion; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..372
FT /note="Solute carrier family 35 member F6"
FT /id="PRO_0000232515"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 105..160
FT /note="EamA"
FT MOD_RES 366
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N357"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 36
FT /note="C -> W (in Ref. 1; BAC34613)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="Y -> C (in Ref. 1; BAE30131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 372 AA; 40978 MW; 1F542074F5EB3EAA CRC64;
MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FVAEGCGGSQ EHSFKHPFVQ AVGMFLGEFS
CLAAFYLLKC QGRRQSASSV EPQQPFNTLL FLPPALCDMT GTSIMYVALN MTSASSFQML
RGAVIIFTGL FSVAFLDRRL APSQWLGILI TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD
LLIIMAQIII AIQMVLEEKF VYKHNIHPLQ AVGIEGFFGF VILSLLLVPM FYIPTASFSG
NPRGVLEDAL DAFCQVGRQP LIALALLGNI SSIAFFNFSG ISVTKELSAT TRMVLDTLRT
IVIWAFTLAL GWEIFYPLQI LGFLILLMGT ALYNGLHRPL LAFLSRRWRL PTQEGEQERL
LGDSRTPINE AS
