ID   S35F6_PONAB             Reviewed;         371 AA.
AC   Q5RFT1;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Solute carrier family 35 member F6;
DE   AltName: Full=ANT2-binding protein;
DE            Short=ANT2BP;
DE   AltName: Full=Transport and Golgi organization 9 homolog;
DE   Flags: Precursor;
GN   Name=SLC35F6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maintenance of mitochondrial membrane
CC       potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes
CC       pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as
CC       a nucleotide-sugar transporter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SLC25A5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Lysosome membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC       {ECO:0000305}.
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DR   EMBL; CR857071; CAH89376.1; -; mRNA.
DR   RefSeq; NP_001124578.1; NM_001131106.1.
DR   AlphaFoldDB; Q5RFT1; -.
DR   SMR; Q5RFT1; -.
DR   STRING; 9601.ENSPPYP00000014041; -.
DR   GeneID; 100171413; -.
DR   KEGG; pon:100171413; -.
DR   CTD; 54978; -.
DR   eggNOG; KOG3912; Eukaryota.
DR   InParanoid; Q5RFT1; -.
DR   OrthoDB; 1169953at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR009262; SLC35_F1/F2/F6.
DR   InterPro; IPR012404; UCP036436.
DR   Pfam; PF06027; SLC35F; 1.
DR   PIRSF; PIRSF036436; UCP036436; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Mitochondrion; Phosphoprotein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..371
FT                   /note="Solute carrier family 35 member F6"
FT                   /id="PRO_0000232516"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          104..160
FT                   /note="EamA"
FT   REGION          347..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         365
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N357"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   371 AA;  40216 MW;  DFE5A679912AA5AC CRC64;
     MAWTKHQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ AVGMFLGEFS
     CLAAFYLLRC RATGQSDSSV DPQQPFNPLL FLPPALCDMT GTSLMYVALN MTSASSFQML
     RGAVIIFTGL FSVAFLGRRL VLSQWLGILA TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD
     LLIIMAQIIV AIQMVLEEKF VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG
     NPRGTLEDAL DAFCQVGRQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT
     VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPP AEESEQERLL
     GGSRTPINDA S