ID   S35F6_RAT               Reviewed;         372 AA.
AC   Q5RKH7;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Solute carrier family 35 member F6;
DE   AltName: Full=ANT2-binding protein;
DE            Short=ANT2BP;
DE   AltName: Full=Transport and Golgi organization 9 homolog;
DE   Flags: Precursor;
GN   Name=Slc35f6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the maintenance of mitochondrial membrane
CC       potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes
CC       pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as
CC       a nucleotide-sugar transporter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SLC25A5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Lysosome membrane
CC       {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLC35F solute transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BC085904; AAH85904.1; -; mRNA.
DR   RefSeq; NP_001017451.1; NM_001017451.1.
DR   AlphaFoldDB; Q5RKH7; -.
DR   STRING; 10116.ENSRNOP00000012558; -.
DR   GlyGen; Q5RKH7; 1 site.
DR   jPOST; Q5RKH7; -.
DR   PaxDb; Q5RKH7; -.
DR   PRIDE; Q5RKH7; -.
DR   Ensembl; ENSRNOT00000012558; ENSRNOP00000012558; ENSRNOG00000009459.
DR   GeneID; 298851; -.
DR   KEGG; rno:298851; -.
DR   CTD; 54978; -.
DR   RGD; 1309228; Slc35f6.
DR   eggNOG; KOG3912; Eukaryota.
DR   GeneTree; ENSGT00390000017237; -.
DR   HOGENOM; CLU_025028_1_0_1; -.
DR   InParanoid; Q5RKH7; -.
DR   OMA; LWSKWQD; -.
DR   OrthoDB; 1169953at2759; -.
DR   PhylomeDB; Q5RKH7; -.
DR   TreeFam; TF105890; -.
DR   PRO; PR:Q5RKH7; -.
DR   Proteomes; UP000002494; Chromosome 6.
DR   Bgee; ENSRNOG00000009459; Expressed in liver and 19 other tissues.
DR   Genevisible; Q5RKH7; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0005764; C:lysosome; ISO:RGD.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   InterPro; IPR009262; SLC35_F1/F2/F6.
DR   InterPro; IPR012404; UCP036436.
DR   Pfam; PF06027; SLC35F; 1.
DR   PIRSF; PIRSF036436; UCP036436; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Lysosome; Membrane; Mitochondrion; Phosphoprotein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..372
FT                   /note="Solute carrier family 35 member F6"
FT                   /id="PRO_0000232517"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          105..160
FT                   /note="EamA"
FT   MOD_RES         366
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N357"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   372 AA;  41092 MW;  47649083703DC568 CRC64;
     MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FEAEGCGGSQ EHSFKHPFVQ AVGMFLGEFS
     CLAAFYLLKC RARRQSDSSV EPRQPFNALL FLPPALCDMT GTSIMYVALN MTSASSFQML
     RGAVIIFTGL FSVAFLDRRL VPSQWLGILI TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD
     LLIIMAQIII AIQMVLEEKF VYKHNIHPLQ AVGIEGFFGF VILSLLLVPM YYIPTASFSG
     NPRGVLEDAL DAFCQVGRQP LIALALLGNI SSIAFFNFSG ISVTKELSAT TRMVLDTLRT
     VVIWAFTLAL GWEVFHPLQI LGFLILLMGT ALYNGLHRPL LACLSRRWRH PTQEGEQERL
     LGDSRTPINE TS