S35G1_MOUSE
ID S35G1_MOUSE Reviewed; 368 AA.
AC Q8BY79; B2RPY9;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Solute carrier family 35 member G1;
DE AltName: Full=Transmembrane protein 20;
GN Name=Slc35g1; Synonyms=Tmem20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in intracellular calcium sensing and
CC homeostasis. May act as a negative regulator of plasma membrane
CC calcium-transporting ATPases preventing calcium efflux from the cell
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STIM1; stimulated by depletion of intracellular
CC calcium. Interacts with ORAI1. Interacts with the plasma membrane
CC calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1,
CC ATP2A2, KPNB1 and XPO1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Note=Translocates from the
CC endoplasmic reticulum to the cell membrane in response to a depletion
CC of intracellular calcium and is detected at punctae corresponding to
CC junctions between the endoplasmic reticulum and the cell membrane.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TMEM20 family. {ECO:0000305}.
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DR EMBL; AK041618; BAC31006.1; -; mRNA.
DR EMBL; AK171987; BAE42760.1; -; mRNA.
DR EMBL; BC137663; AAI37664.1; -; mRNA.
DR EMBL; BC137664; AAI37665.1; -; mRNA.
DR CCDS; CCDS29787.1; -.
DR RefSeq; NP_780716.1; NM_175507.3.
DR AlphaFoldDB; Q8BY79; -.
DR SMR; Q8BY79; -.
DR BioGRID; 232219; 1.
DR STRING; 10090.ENSMUSP00000061282; -.
DR TCDB; 2.A.7.28.1; the drug/metabolite transporter (dmt) superfamily.
DR PhosphoSitePlus; Q8BY79; -.
DR PaxDb; Q8BY79; -.
DR PeptideAtlas; Q8BY79; -.
DR PRIDE; Q8BY79; -.
DR ProteomicsDB; 260775; -.
DR DNASU; 240660; -.
DR Ensembl; ENSMUST00000054098; ENSMUSP00000061282; ENSMUSG00000044026.
DR GeneID; 240660; -.
DR KEGG; mmu:240660; -.
DR UCSC; uc008hjn.1; mouse.
DR CTD; 159371; -.
DR MGI; MGI:2444789; Slc35g1.
DR VEuPathDB; HostDB:ENSMUSG00000044026; -.
DR eggNOG; KOG4510; Eukaryota.
DR GeneTree; ENSGT00940000153249; -.
DR HOGENOM; CLU_032828_1_2_1; -.
DR InParanoid; Q8BY79; -.
DR OMA; MGVCVKL; -.
DR OrthoDB; 630849at2759; -.
DR PhylomeDB; Q8BY79; -.
DR TreeFam; TF323956; -.
DR BioGRID-ORCS; 240660; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8BY79; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8BY79; protein.
DR Bgee; ENSMUSG00000044026; Expressed in urinary bladder urothelium and 155 other tissues.
DR Genevisible; Q8BY79; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:1990034; P:calcium ion export across plasma membrane; ISO:MGI.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:MGI.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..368
FT /note="Solute carrier family 35 member G1"
FT /id="PRO_0000244464"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 83..205
FT /note="EamA 1"
FT DOMAIN 236..360
FT /note="EamA 2"
SQ SEQUENCE 368 AA; 40217 MW; F0BEC10BC67457DF CRC64;
MGPPESAAEL AAEAVELREP ELQLADPASP GEEHVDVEAE GAPGRGRCWP CGAWACGSRG
EPEAKKKAPC PGLGLFYTVL SAFLFSVASL FVKKVQGVHA VEISAFRCVV QMLVIIPCLI
YRKTGFIGPK GQRLFLFLRG VFGSSAMILM YYAFQTTSLA DATVIAFSCP VFTSIFAWIF
LKEKYSLWDA FFTLFAIAGV ILIVRPPFIF GSDTSGMRES YSEHIKGTFA AIGHAVLAAI
TLVILRKMGK SVDYFLSIWY YVILGLPEAI IILFVIGEWS LPYCGLDRLF LILIGLLGLG
GQIFITKAVQ IEKAGLVAIM KTMDIVFAFI FQIAFFDNVP TWWTVGGALC VVVSTTGATI
RRWLQGSK
