S35G2_HUMAN
ID S35G2_HUMAN Reviewed; 412 AA.
AC Q8TBE7; B2RA80; D3DNE1; Q9BWN4; Q9H0S6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Solute carrier family 35 member G2 {ECO:0000312|HGNC:HGNC:28480};
DE AltName: Full=Transmembrane protein 22 {ECO:0000303|PubMed:19148500};
GN Name=SLC35G2 {ECO:0000312|HGNC:HGNC:28480};
GN Synonyms=TMEM22 {ECO:0000303|PubMed:19148500};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-400.
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-400.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-400.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, VARIANT [LARGE SCALE
RP ANALYSIS] ARG-400, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, VARIANT [LARGE SCALE
RP ANALYSIS] ARG-400, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [8]
RP SUBCELLULAR LOCATION, TOPOLOGY, AND INTERACTION WITH RAB37.
RX PubMed=19148500;
RA Dobashi S., Katagiri T., Hirota E., Ashida S., Daigo Y., Shuin T.,
RA Fujioka T., Miki T., Nakamura Y.;
RT "Involvement of TMEM22 overexpression in the growth of renal cell carcinoma
RT cells.";
RL Oncol. Rep. 21:305-312(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, VARIANT [LARGE SCALE
RP ANALYSIS] ARG-400, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May play a role in cell proliferation.
CC {ECO:0000305|PubMed:19148500}.
CC -!- SUBUNIT: Interacts with RAB37. {ECO:0000269|PubMed:19148500}.
CC -!- INTERACTION:
CC Q8TBE7; Q13520: AQP6; NbExp=3; IntAct=EBI-727304, EBI-13059134;
CC Q8TBE7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-727304, EBI-18304435;
CC Q8TBE7; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-727304, EBI-18159983;
CC Q8TBE7; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-727304, EBI-2548832;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19148500};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH00111.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL136661; CAB66596.1; -; mRNA.
DR EMBL; AK314079; BAG36777.1; -; mRNA.
DR EMBL; AC011597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79111.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79112.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79113.1; -; Genomic_DNA.
DR EMBL; BC000111; AAH00111.1; ALT_INIT; mRNA.
DR EMBL; BC022557; AAH22557.1; -; mRNA.
DR CCDS; CCDS3091.1; -.
DR RefSeq; NP_001091068.1; NM_001097599.1.
DR RefSeq; NP_001091069.1; NM_001097600.1.
DR RefSeq; NP_079522.2; NM_025246.2.
DR RefSeq; XP_006713836.1; XM_006713773.3.
DR RefSeq; XP_011511516.1; XM_011513214.2.
DR RefSeq; XP_016862778.1; XM_017007289.1.
DR RefSeq; XP_016862779.1; XM_017007290.1.
DR RefSeq; XP_016862780.1; XM_017007291.1.
DR AlphaFoldDB; Q8TBE7; -.
DR SMR; Q8TBE7; -.
DR BioGRID; 123273; 24.
DR IntAct; Q8TBE7; 14.
DR STRING; 9606.ENSP00000400839; -.
DR TCDB; 2.A.7.28.2; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q8TBE7; -.
DR PhosphoSitePlus; Q8TBE7; -.
DR BioMuta; SLC35G2; -.
DR DMDM; 317373497; -.
DR EPD; Q8TBE7; -.
DR jPOST; Q8TBE7; -.
DR MassIVE; Q8TBE7; -.
DR MaxQB; Q8TBE7; -.
DR PaxDb; Q8TBE7; -.
DR PeptideAtlas; Q8TBE7; -.
DR PRIDE; Q8TBE7; -.
DR ProteomicsDB; 74001; -.
DR Antibodypedia; 62894; 51 antibodies from 14 providers.
DR DNASU; 80723; -.
DR Ensembl; ENST00000393079.3; ENSP00000376794.3; ENSG00000168917.9.
DR Ensembl; ENST00000446465.3; ENSP00000400839.2; ENSG00000168917.9.
DR GeneID; 80723; -.
DR KEGG; hsa:80723; -.
DR MANE-Select; ENST00000446465.3; ENSP00000400839.2; NM_025246.3; NP_079522.2.
DR UCSC; uc003erf.5; human.
DR CTD; 80723; -.
DR DisGeNET; 80723; -.
DR GeneCards; SLC35G2; -.
DR HGNC; HGNC:28480; SLC35G2.
DR HPA; ENSG00000168917; Low tissue specificity.
DR MIM; 617812; gene.
DR neXtProt; NX_Q8TBE7; -.
DR OpenTargets; ENSG00000168917; -.
DR PharmGKB; PA134946375; -.
DR VEuPathDB; HostDB:ENSG00000168917; -.
DR eggNOG; ENOG502QV4H; Eukaryota.
DR GeneTree; ENSGT00940000153249; -.
DR HOGENOM; CLU_055637_0_0_1; -.
DR InParanoid; Q8TBE7; -.
DR OMA; SSQKYPV; -.
DR OrthoDB; 630849at2759; -.
DR PhylomeDB; Q8TBE7; -.
DR TreeFam; TF331838; -.
DR PathwayCommons; Q8TBE7; -.
DR SignaLink; Q8TBE7; -.
DR BioGRID-ORCS; 80723; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; SLC35G2; human.
DR GeneWiki; TMEM22; -.
DR GenomeRNAi; 80723; -.
DR Pharos; Q8TBE7; Tdark.
DR PRO; PR:Q8TBE7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8TBE7; protein.
DR Bgee; ENSG00000168917; Expressed in sperm and 150 other tissues.
DR Genevisible; Q8TBE7; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..412
FT /note="Solute carrier family 35 member G2"
FT /id="PRO_0000244465"
FT TOPO_DOM 1..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:19148500"
FT TRANSMEM 105..125
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..130
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 131..151
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 169..189
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..193
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 194..214
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 218..238
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..254
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..318
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 319..339
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 346..366
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 367
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:19148500"
FT TRANSMEM 368..388
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..412
FT /note="Cytoplasmic"
FT /evidence="ECO:0000269|PubMed:19148500"
FT DOMAIN 119..237
FT /note="EamA 1"
FT /evidence="ECO:0000255"
FT DOMAIN 268..388
FT /note="EamA 2"
FT /evidence="ECO:0000255"
FT MOD_RES 409
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983,
FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163"
FT VARIANT 400
FT /note="K -> R (in dbSNP:rs1052618)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4,
FT ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976,
FT ECO:0007744|PubMed:23186163"
FT /id="VAR_026907"
FT CONFLICT 155
FT /note="Q -> E (in Ref. 5; AAH22557)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 412 AA; 46422 MW; 94EB36A60A83355D CRC64;
MDTSPSRKYP VKKRVKIHPN TVMVKYTSHY PQPGDDGYEE INEGYGNFME ENPKKGLLSE
MKKKGRAFFG TMDTLPPPTE DPMINEIGQF QSFAEKNIFQ SRKMWIVLFG SALAHGCVAL
ITRLVSDRSK VPSLELIFIR SVFQVLSVLV VCYYQEAPFG PSGYRLRLFF YGVCNVISIT
CAYTSFSIVP PSNGTTMWRA TTTVFSAILA FLLVDEKMAY VDMATVVCSI LGVCLVMIPN
IVDEDNSLLN AWKEAFGYTM TVMAGLTTAL SMIVYRSIKE KISMWTALFT FGWTGTIWGI
STMFILQEPI IPLDGETWSY LIAICVCSTA AFLGVYYALD KFHPALVSTV QHLEIVVAMV
LQLLVLHIFP SIYDVFGGVI IMISVFVLAG YKLYWRNLRK QDYQEILDSP IK
