ID   S35G2_MOUSE             Reviewed;         412 AA.
AC   D3YVE8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Solute carrier family 35 member G2;
DE   AltName: Full=Transmembrane protein 22;
GN   Name=Slc35g2; Synonyms=Tmem22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AC129223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466560; EDL21032.1; -; Genomic_DNA.
DR   CCDS; CCDS52898.1; -.
DR   RefSeq; NP_001094953.1; NM_001101483.1.
DR   AlphaFoldDB; D3YVE8; -.
DR   SMR; D3YVE8; -.
DR   STRING; 10090.ENSMUSP00000091308; -.
DR   iPTMnet; D3YVE8; -.
DR   PhosphoSitePlus; D3YVE8; -.
DR   MaxQB; D3YVE8; -.
DR   PaxDb; D3YVE8; -.
DR   PRIDE; D3YVE8; -.
DR   ProteomicsDB; 260776; -.
DR   Antibodypedia; 62894; 51 antibodies from 14 providers.
DR   Ensembl; ENSMUST00000093792; ENSMUSP00000091308; ENSMUSG00000070287.
DR   GeneID; 245020; -.
DR   KEGG; mmu:245020; -.
DR   UCSC; uc012gze.1; mouse.
DR   CTD; 80723; -.
DR   MGI; MGI:2685365; Slc35g2.
DR   VEuPathDB; HostDB:ENSMUSG00000070287; -.
DR   eggNOG; ENOG502QV4H; Eukaryota.
DR   GeneTree; ENSGT00940000153249; -.
DR   HOGENOM; CLU_055637_0_0_1; -.
DR   InParanoid; D3YVE8; -.
DR   OMA; SSQKYPV; -.
DR   OrthoDB; 630849at2759; -.
DR   PhylomeDB; D3YVE8; -.
DR   TreeFam; TF331838; -.
DR   BioGRID-ORCS; 245020; 0 hits in 72 CRISPR screens.
DR   PRO; PR:D3YVE8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; D3YVE8; protein.
DR   Bgee; ENSMUSG00000070287; Expressed in islet of Langerhans and 92 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..412
FT                   /note="Solute carrier family 35 member G2"
FT                   /id="PRO_0000416119"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          121..237
FT                   /note="EamA 1"
FT   DOMAIN          268..388
FT                   /note="EamA 2"
FT   MOD_RES         409
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   412 AA;  46395 MW;  975066E4E68A7E4D CRC64;
     MDTSPSKKYP IKKRVKIHPN TVMVKYTSHY PQPGDDGYEE INEDYGRFME ENPKKSLLSE
     MRRKGRTLFG TMDTQPSSSE DPRASGMGQF QSFAEKNIFQ SRKMWLVLFG SALAHGCVAL
     ITRLISDRSK VPSLELIFIR SVLQVLSVIV VCYYQEAPFG PSGYRLRLFF YGVCNVISIT
     CAYTSFSIVP PSNGTTMWRA TTTVFSAILA FLLVDEKMAY VDMATVVCSI LGVCLVMIPN
     IADEDNSLLN AWKEAFGYTM TVMAGLTTAL SMIVYRSIRE KISMWTALFT FGWTGTIWGL
     STMFVLQEPI IPLDGATWSY LIAICLCSTA AFLGVYYALD KFHPALVSTV QHLEIVVAMV
     LQLLVLHIFP SVYDVFGGVI IMISVFVLAG YKLYWRNVRR EDYQEILDSP IK