ID   S35G2_RAT               Reviewed;         412 AA.
AC   Q5M7A3;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Solute carrier family 35 member G2;
DE   AltName: Full=Transmembrane protein 22;
GN   Name=Slc35g2; Synonyms=Tmem22;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BC088758; AAH88758.1; -; mRNA.
DR   RefSeq; NP_001012126.1; NM_001012126.1.
DR   RefSeq; XP_006243692.1; XM_006243630.3.
DR   RefSeq; XP_017451168.1; XM_017595679.1.
DR   AlphaFoldDB; Q5M7A3; -.
DR   SMR; Q5M7A3; -.
DR   STRING; 10116.ENSRNOP00000020610; -.
DR   iPTMnet; Q5M7A3; -.
DR   PhosphoSitePlus; Q5M7A3; -.
DR   PaxDb; Q5M7A3; -.
DR   PRIDE; Q5M7A3; -.
DR   Ensembl; ENSRNOT00000020610; ENSRNOP00000020610; ENSRNOG00000015370.
DR   Ensembl; ENSRNOT00000110639; ENSRNOP00000078957; ENSRNOG00000015370.
DR   GeneID; 315957; -.
DR   KEGG; rno:315957; -.
DR   UCSC; RGD:1306109; rat.
DR   CTD; 80723; -.
DR   RGD; 1306109; Slc35g2.
DR   eggNOG; ENOG502QV4H; Eukaryota.
DR   GeneTree; ENSGT00940000153249; -.
DR   HOGENOM; CLU_055637_0_0_1; -.
DR   InParanoid; Q5M7A3; -.
DR   OMA; SSQKYPV; -.
DR   OrthoDB; 630849at2759; -.
DR   PhylomeDB; Q5M7A3; -.
DR   TreeFam; TF331838; -.
DR   PRO; PR:Q5M7A3; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000015370; Expressed in cerebellum and 11 other tissues.
DR   Genevisible; Q5M7A3; RN.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..412
FT                   /note="Solute carrier family 35 member G2"
FT                   /id="PRO_0000244466"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          113..238
FT                   /note="EamA 1"
FT   DOMAIN          266..390
FT                   /note="EamA 2"
FT   REGION          68..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..88
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         409
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   412 AA;  46596 MW;  D6ECD206BB572B6B CRC64;
     MDTSPSKKYP IKKRVKIHPN TVMVKYTSHY PQPGEDGYEE INEDYGRFME ENPKKSLLSE
     MRRKGRTLFG TMDTQPPRSE DPRASSRGQF QSFAEKNIFQ SRKMWLVLFG SALAHGCVAL
     ITRLVSDRSK VPSLELIFIR SVLQVLSVIV VCYYQEAPFG PSGYRLRLFL YGVCNVISIT
     CAYTSFSIVP PSNGTTMWRA TTTVFSAVLA FLLVDEKMAY VDMATVVCSI LGVCLVMIPN
     IADEDNSLLN VWKEAFGYTM TVMAGLTTAL SMIVYRSIRE KISMWTALFT FGWTGTIWGL
     STMFVLQEPI IPLDGETWSY LIAICICSTV AFLGVYYALD KFHPALVSTV QHLEIVVAMV
     LQLLVLHIFP SVYDVFGGVI IMISVFVLAG YKLYWRNVRR EDYQEILDSP IK