S35G3_HUMAN
ID S35G3_HUMAN Reviewed; 338 AA.
AC Q8N808; B9EGE9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Solute carrier family 35 member G3;
DE AltName: Full=Acyl-malonyl-condensing enzyme 1;
DE AltName: Full=Transmembrane protein 21A;
GN Name=SLC35G3; Synonyms=AMAC1, TMEM21A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17101974; DOI=10.1073/pnas.0603224103;
RA Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.;
RT "Emergence of primate genes by retrotransposon-mediated sequence
RT transduction.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:17101974}.
CC -!- MISCELLANEOUS: The gene encoding this protein appears to have arisen by
CC SVA-mediated retrotransposition of the SLC35G6 gene in the primate
CC lineage.
CC -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK097473; BAC05067.1; -; mRNA.
DR EMBL; CH471147; EAW80161.1; -; Genomic_DNA.
DR EMBL; BC136422; AAI36423.1; -; mRNA.
DR EMBL; BC140700; AAI40701.1; -; mRNA.
DR CCDS; CCDS11293.1; -.
DR RefSeq; NP_689675.1; NM_152462.2.
DR AlphaFoldDB; Q8N808; -.
DR SMR; Q8N808; -.
DR STRING; 9606.ENSP00000297307; -.
DR TCDB; 2.A.7.28.7; the drug/metabolite transporter (dmt) superfamily.
DR BioMuta; SLC35G3; -.
DR DMDM; 74729329; -.
DR PaxDb; Q8N808; -.
DR PeptideAtlas; Q8N808; -.
DR PRIDE; Q8N808; -.
DR Antibodypedia; 64101; 16 antibodies from 8 providers.
DR DNASU; 146861; -.
DR Ensembl; ENST00000297307.7; ENSP00000297307.5; ENSG00000164729.8.
DR GeneID; 146861; -.
DR KEGG; hsa:146861; -.
DR MANE-Select; ENST00000297307.7; ENSP00000297307.5; NM_152462.2; NP_689675.1.
DR UCSC; uc002hjd.3; human.
DR CTD; 146861; -.
DR GeneCards; SLC35G3; -.
DR HGNC; HGNC:26848; SLC35G3.
DR HPA; ENSG00000164729; Tissue enriched (testis).
DR neXtProt; NX_Q8N808; -.
DR PharmGKB; PA134902447; -.
DR VEuPathDB; HostDB:ENSG00000164729; -.
DR eggNOG; ENOG502RCFC; Eukaryota.
DR GeneTree; ENSGT00940000153249; -.
DR HOGENOM; CLU_055637_0_0_1; -.
DR InParanoid; Q8N808; -.
DR OMA; LSVACAY; -.
DR OrthoDB; 1144983at2759; -.
DR PhylomeDB; Q8N808; -.
DR TreeFam; TF331838; -.
DR PathwayCommons; Q8N808; -.
DR BioGRID-ORCS; 146861; 42 hits in 991 CRISPR screens.
DR ChiTaRS; SLC35G3; human.
DR GenomeRNAi; 146861; -.
DR Pharos; Q8N808; Tdark.
DR PRO; PR:Q8N808; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8N808; protein.
DR Bgee; ENSG00000164729; Expressed in buccal mucosa cell and 9 other tissues.
DR Genevisible; Q8N808; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR000620; EamA_dom.
DR Pfam; PF00892; EamA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..338
FT /note="Solute carrier family 35 member G3"
FT /id="PRO_0000269553"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..174
FT /note="EamA 1"
FT DOMAIN 272..325
FT /note="EamA 2"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 35381 MW; 6BD0FD8D7A797A35 CRC64;
MAGSHPYFNQ PDSTHPSPPS APPSLRWYQR CQPSDATSGL LVALLGGGLP AGFVGPLSRM
AYQASNLPSL ELLIWRCLFH LPIALLLKLR GDPLLGTPDI RSRAFFCALL NILSIGCAYS
AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGCILGLI IIVGPGLWTL
QEGTTGVYTA LGYVEAFLGG LALSLRLLVY RSLHFPPCLP TVAFLSGLVG LLGSVPGLFV
LQAPVLPSDL LSWSCVGAVG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
LHETVAPSDI VAAGVVLGSI AIITAQNLSC ERTGRVEE
