ID   S35G4_HUMAN             Reviewed;         338 AA.
AC   P0C7Q5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Putative solute carrier family 35 member G4;
DE   AltName: Full=Acyl-malonyl-condensing enzyme 1-like protein 1;
GN   Name=SLC35G4; Synonyms=AMAC1L1, SLC35G4P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2]
RP   GENE EVOLUTION.
RX   PubMed=17101974; DOI=10.1073/pnas.0603224103;
RA   Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.;
RT   "Emergence of primate genes by retrotransposon-mediated sequence
RT   transduction.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. The intronless gene
CC       encoding this protein has arisen by SVA-mediated retrotransposition of
CC       the SLC35G6 gene in the primate lineage. There is no evidence for
CC       transcription (PubMed:17101974). {ECO:0000305|PubMed:17101974}.
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DR   EMBL; AP001120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS82241.1; -.
DR   RefSeq; NP_001269229.1; NM_001282300.1.
DR   AlphaFoldDB; P0C7Q5; -.
DR   SMR; P0C7Q5; -.
DR   STRING; 9606.ENSP00000485584; -.
DR   TCDB; 2.A.7.28.4; the drug/metabolite transporter (dmt) superfamily.
DR   BioMuta; SLC35G4; -.
DR   DMDM; 193806689; -.
DR   PeptideAtlas; P0C7Q5; -.
DR   PRIDE; P0C7Q5; -.
DR   ProteomicsDB; 52360; -.
DR   Antibodypedia; 79249; 6 antibodies from 3 providers.
DR   DNASU; 646000; -.
DR   Ensembl; ENST00000588001.2; ENSP00000490812.1; ENSG00000236396.8.
DR   GeneID; 646000; -.
DR   KEGG; hsa:646000; -.
DR   MANE-Select; ENST00000588001.2; ENSP00000490812.1; NM_001282300.2; NP_001269229.1.
DR   CTD; 646000; -.
DR   GeneCards; SLC35G4; -.
DR   HGNC; HGNC:31043; SLC35G4.
DR   HPA; ENSG00000236396; Not detected.
DR   neXtProt; NX_P0C7Q5; -.
DR   OpenTargets; ENSG00000236396; -.
DR   PharmGKB; PA134875980; -.
DR   VEuPathDB; HostDB:ENSG00000236396; -.
DR   eggNOG; ENOG502RCFC; Eukaryota.
DR   GeneTree; ENSGT00940000153249; -.
DR   InParanoid; P0C7Q5; -.
DR   OMA; RNLICER; -.
DR   OrthoDB; 1144983at2759; -.
DR   PhylomeDB; P0C7Q5; -.
DR   SignaLink; P0C7Q5; -.
DR   BioGRID-ORCS; 646000; 4 hits in 112 CRISPR screens.
DR   GenomeRNAi; 646000; -.
DR   Pharos; P0C7Q5; Tdark.
DR   PRO; PR:P0C7Q5; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; P0C7Q5; protein.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
PE   5: Uncertain;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..338
FT                   /note="Putative solute carrier family 35 member G4"
FT                   /id="PRO_0000342675"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          49..174
FT                   /note="EamA 1"
FT   DOMAIN          272..325
FT                   /note="EamA 2"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         104
FT                   /note="T -> A (in dbSNP:rs8087447)"
FT                   /id="VAR_061556"
SQ   SEQUENCE   338 AA;  35378 MW;  E99932C4BE7683D9 CRC64;
     MAGSHPYFNL PDSTHPSPPS TPPSLHWHQR CQPSDATNGL LVALLGGGLP AGFVGPLSRM
     AYQASNLPSL ELVICRCLFH LPIALLLKLR GDPLLGPPDI RGRTCFCALL NVLNIGCAYS
     AVQVVPTGNA ATVRKHSSTV CSAILTLCLE SQVLSGYDWC GLLGSILGLI IIVGPGLWTL
     QEGTTGVYTG LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV
     LQSPVLPSDL LSWSCVGAVG ILTLVSFTCV GYAVTKAHPA LVCAVLHSEV VMALILQYFM
     LHETVAPSDI MGAGVVLGSI AIITARNLIC ERTGKVEE