S35G5_HUMAN
ID S35G5_HUMAN Reviewed; 338 AA.
AC Q96KT7; A2RRL6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Solute carrier family 35 member G5;
DE AltName: Full=Acyl-malonyl-condensing enzyme 1-like protein 2;
GN Name=SLC35G5; Synonyms=AMAC, AMAC1L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11896452; DOI=10.1038/sj.ejhg.5200750;
RA Appel S., Filter M., Reis A., Hennies H.C., Bergheim A., Ogilvie E.,
RA Arndt S., Simmons A., Lovett M., Hide W., Ramsay M., Reichwald K.,
RA Zimmermann W., Rosenthal A.;
RT "Physical and transcriptional map of the critical region for keratolytic
RT winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759.";
RL Eur. J. Hum. Genet. 10:17-25(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17101974; DOI=10.1073/pnas.0603224103;
RA Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.;
RT "Emergence of primate genes by retrotransposon-mediated sequence
RT transduction.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006).
CC -!- INTERACTION:
CC Q96KT7; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-13598465, EBI-747430;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta and testis.
CC {ECO:0000269|PubMed:17101974}.
CC -!- MISCELLANEOUS: The gene encoding this protein appears to have arisen by
CC SVA-mediated retrotransposition of the SLC35G6 gene in the primate
CC lineage.
CC -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AJ291677; CAC82744.1; -; mRNA.
DR EMBL; BC131696; AAI31697.1; -; mRNA.
DR CCDS; CCDS5980.1; -.
DR RefSeq; NP_473369.1; NM_054028.1.
DR AlphaFoldDB; Q96KT7; -.
DR SMR; Q96KT7; -.
DR BioGRID; 123711; 1.
DR IntAct; Q96KT7; 1.
DR STRING; 9606.ENSP00000371872; -.
DR TCDB; 2.A.7.28.5; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; Q96KT7; -.
DR PhosphoSitePlus; Q96KT7; -.
DR BioMuta; SLC35G5; -.
DR DMDM; 74751987; -.
DR MassIVE; Q96KT7; -.
DR PaxDb; Q96KT7; -.
DR PeptideAtlas; Q96KT7; -.
DR PRIDE; Q96KT7; -.
DR Antibodypedia; 54539; 58 antibodies from 12 providers.
DR DNASU; 83650; -.
DR Ensembl; ENST00000382435.5; ENSP00000371872.5; ENSG00000177710.6.
DR Ensembl; ENST00000646844.3; ENSP00000495515.1; ENSG00000285084.3.
DR GeneID; 83650; -.
DR KEGG; hsa:83650; -.
DR MANE-Select; ENST00000382435.5; ENSP00000371872.5; NM_054028.2; NP_473369.1.
DR UCSC; uc003wtp.2; human.
DR CTD; 83650; -.
DR GeneCards; SLC35G5; -.
DR HGNC; HGNC:15546; SLC35G5.
DR HPA; ENSG00000177710; Tissue enhanced (testis).
DR MIM; 615199; gene.
DR neXtProt; NX_Q96KT7; -.
DR OpenTargets; ENSG00000177710; -.
DR PharmGKB; PA24756; -.
DR VEuPathDB; HostDB:ENSG00000177710; -.
DR eggNOG; ENOG502RCFC; Eukaryota.
DR GeneTree; ENSGT00940000153249; -.
DR HOGENOM; CLU_055637_0_0_1; -.
DR InParanoid; Q96KT7; -.
DR OrthoDB; 1144983at2759; -.
DR PhylomeDB; Q96KT7; -.
DR TreeFam; TF331838; -.
DR PathwayCommons; Q96KT7; -.
DR SignaLink; Q96KT7; -.
DR BioGRID-ORCS; 83650; 11 hits in 990 CRISPR screens.
DR GenomeRNAi; 83650; -.
DR Pharos; Q96KT7; Tbio.
DR PRO; PR:Q96KT7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96KT7; protein.
DR Bgee; ENSG00000177710; Expressed in granulocyte and 56 other tissues.
DR Genevisible; Q96KT7; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..338
FT /note="Solute carrier family 35 member G5"
FT /id="PRO_0000269556"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..174
FT /note="EamA 1"
FT DOMAIN 272..325
FT /note="EamA 2"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 46
FT /note="G -> D (in dbSNP:rs6990563)"
FT /id="VAR_059579"
FT VARIANT 307
FT /note="L -> P (in dbSNP:rs12681991)"
FT /id="VAR_059580"
SQ SEQUENCE 338 AA; 35161 MW; 8421C9A5E1E48D35 CRC64;
MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP AGFVGPLSRM
AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGWACFCALL NVLSIGCAYS
AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLGGYEWC GLLGSILGLI IILGPGLWTL
QEGTTGVYTT LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV
LQTPVLPSDL LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE
