S35G6_HUMAN
ID S35G6_HUMAN Reviewed; 338 AA.
AC P0C7Q6;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Solute carrier family 35 member G6;
DE AltName: Full=Acyl-malonyl-condensing enzyme 1-like protein 3;
DE AltName: Full=Transmembrane protein 21B;
GN Name=SLC35G6; Synonyms=AMAC1L3, TMEM21B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP TISSUE SPECIFICITY, AND GENE EVOLUTION.
RX PubMed=17101974; DOI=10.1073/pnas.0603224103;
RA Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.;
RT "Emergence of primate genes by retrotransposon-mediated sequence
RT transduction.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in placenta and testis.
CC {ECO:0000269|PubMed:17101974}.
CC -!- MISCELLANEOUS: This gene appears to be the source locus of an SVA-
CC mediated retrotransposition event that gave rise to SLC35G3, SLC35G4
CC and SLC35G5 genes.
CC -!- SIMILARITY: Belongs to the SLC35G solute transporter family.
CC {ECO:0000305}.
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DR EMBL; AC113189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45603.1; -.
DR RefSeq; NP_001096084.1; NM_001102614.1.
DR AlphaFoldDB; P0C7Q6; -.
DR SMR; P0C7Q6; -.
DR STRING; 9606.ENSP00000396523; -.
DR TCDB; 2.A.7.28.6; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; P0C7Q6; -.
DR PhosphoSitePlus; P0C7Q6; -.
DR BioMuta; SLC35G6; -.
DR DMDM; 193806690; -.
DR PaxDb; P0C7Q6; -.
DR PeptideAtlas; P0C7Q6; -.
DR PRIDE; P0C7Q6; -.
DR DNASU; 643664; -.
DR Ensembl; ENST00000412468.4; ENSP00000396523.2; ENSG00000259224.3.
DR Ensembl; ENST00000639889.1; ENSP00000491424.1; ENSG00000284515.1.
DR GeneID; 643664; -.
DR KEGG; hsa:643664; -.
DR MANE-Select; ENST00000412468.4; ENSP00000396523.2; NM_001102614.2; NP_001096084.1.
DR UCSC; uc010cmj.2; human.
DR CTD; 643664; -.
DR GeneCards; SLC35G6; -.
DR HGNC; HGNC:31351; SLC35G6.
DR HPA; ENSG00000259224; Tissue enriched (testis).
DR neXtProt; NX_P0C7Q6; -.
DR PharmGKB; PA134919830; -.
DR VEuPathDB; HostDB:ENSG00000259224; -.
DR eggNOG; ENOG502RCFC; Eukaryota.
DR GeneTree; ENSGT00940000153249; -.
DR HOGENOM; CLU_055637_0_0_1; -.
DR InParanoid; P0C7Q6; -.
DR OMA; VTPFDIM; -.
DR OrthoDB; 1144983at2759; -.
DR PhylomeDB; P0C7Q6; -.
DR TreeFam; TF331838; -.
DR PathwayCommons; P0C7Q6; -.
DR SignaLink; P0C7Q6; -.
DR BioGRID-ORCS; 643664; 130 hits in 988 CRISPR screens.
DR GenomeRNAi; 643664; -.
DR Pharos; P0C7Q6; Tdark.
DR PRO; PR:P0C7Q6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P0C7Q6; protein.
DR Bgee; ENSG00000259224; Expressed in right testis and 18 other tissues.
DR Genevisible; P0C7Q6; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..338
FT /note="Solute carrier family 35 member G6"
FT /id="PRO_0000342676"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..174
FT /note="EamA 1"
FT DOMAIN 272..325
FT /note="EamA 2"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 51
FT /note="A -> T (in dbSNP:rs3760422)"
FT /id="VAR_044335"
FT VARIANT 251
FT /note="P -> L (in dbSNP:rs4491591)"
FT /id="VAR_044336"
FT VARIANT 263
FT /note="A -> T (in dbSNP:rs7209977)"
FT /id="VAR_059581"
SQ SEQUENCE 338 AA; 35103 MW; 5E5E5D10245050C3 CRC64;
MAGSHPYLNP PDSTHPSPPS APPSLRWHQC CQPSDATNGL LVALLGGGLP AGFVGPLSHM
AYQASNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGRAYFYALL NVLSIGCAYS
AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGSILGLI IIVGPGLWTL
QEGITGVYTA LGYGQAFVGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGSVPGLFV
LQPPVLPSDL PSWSCVGAVG ILALVSFTCV SYAVTKAHPA LVCAVLHSEV VVALILQYYM
LHETVAPSDI VGAGVVLGSI AIITAWNLSC EREGKVEE
