ID   S35U4_HUMAN             Reviewed;         103 AA.
AC   L0R6Q1;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=SLC35A4 upstream open reading frame protein {ECO:0000305};
GN   Name=SLC35A4 {ECO:0000312|HGNC:HGNC:20753};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE INITIATION (ISOFORM 2).
RX   PubMed=23950983; DOI=10.1371/journal.pone.0070698;
RA   Vanderperre B., Lucier J.-F., Motard J., Tremblay G., Vanderperre S.,
RA   Wisztorski M., Salzet M., Boisvert F.-M., Roucou X.;
RT   "Direct detection of alternative open reading frames translation products
RT   in human significantly expands the proteome.";
RL   PLoS ONE 8:E70698-E70698(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   ALTERNATIVE INITIATION (ISOFORM 2).
RX   PubMed=25621764; DOI=10.7554/elife.03971;
RA   Andreev D.E., O'Connor P.B., Fahey C., Kenny E.M., Terenin I.M.,
RA   Dmitriev S.E., Cormican P., Morris D.W., Shatsky I.N., Baranov P.V.;
RT   "Translation of 5' leaders is pervasive in genes resistant to eIF2
RT   repression.";
RL   Elife 4:E03971-E03971(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=2; Synonyms=uORF {ECO:0000303|PubMed:25621764};
CC         IsoId=L0R6Q1-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q96G79-1; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform 2]: Product of the upstream open reading frame
CC       of this bicistronic gene. This may be the major product of the gene
CC       under normal conditions. {ECO:0000269|PubMed:25621764}.
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DR   EMBL; HF548106; CCO13817.1; -; Genomic_DNA.
DR   EMBL; AC011399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; L0R6Q1; -.
DR   BioMuta; SLC35A4; -.
DR   EPD; L0R6Q1; -.
DR   jPOST; L0R6Q1; -.
DR   MassIVE; L0R6Q1; -.
DR   PeptideAtlas; L0R6Q1; -.
DR   PRIDE; L0R6Q1; -.
DR   Antibodypedia; 45451; 24 antibodies from 12 providers.
DR   Ensembl; ENST00000623481.3; ENSP00000485218.1; ENSG00000176087.16. [L0R6Q1-1]
DR   UCSC; uc063hwg.1; human. [L0R6Q1-1]
DR   GeneCards; SLC35A4; -.
DR   HGNC; HGNC:20753; SLC35A4.
DR   HPA; ENSG00000176087; Low tissue specificity.
DR   neXtProt; NX_L0R6Q1; -.
DR   OpenTargets; ENSG00000176087; -.
DR   VEuPathDB; HostDB:ENSG00000176087; -.
DR   GeneTree; ENSGT00950000182827; -.
DR   HOGENOM; CLU_2262814_0_0_1; -.
DR   PathwayCommons; L0R6Q1; -.
DR   SignaLink; L0R6Q1; -.
DR   ChiTaRS; SLC35A4; human.
DR   Pharos; L0R6Q1; Tdark.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000176087; Expressed in islet of Langerhans and 178 other tissues.
DR   ExpressionAtlas; L0R6Q1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032056; P:positive regulation of translation in response to stress; IDA:UniProtKB.
DR   InterPro; IPR027854; STMP1.
DR   Pfam; PF15054; DUF4535; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..103
FT                   /note="SLC35A4 upstream open reading frame protein"
FT                   /id="PRO_0000439345"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   103 AA;  11133 MW;  7097D4CC63748FE3 CRC64;
     MADDKDSLPK LKDLAFLKNQ LESLQRRVED EVNSGVGQDG SLLSSPFLKG FLAGYVVAKL
     RASAVLGFAV GTCTGIYAAQ AYAVPNVEKT LRDYLQLLRK GPD