S36A3_MOUSE
ID S36A3_MOUSE Reviewed; 477 AA.
AC Q811P0; Q8CH37;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Proton-coupled amino acid transporter 3;
DE Short=Proton/amino acid transporter 3;
DE AltName: Full=Solute carrier family 36 member 3;
DE AltName: Full=Tramdorin-2;
GN Name=Slc36a3; Synonyms=Pat3, Tramd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12809675; DOI=10.1016/s0888-7543(03)00099-5;
RA Boll M., Foltz M., Rubio-Aliaga I., Daniel H.;
RT "A cluster of proton/amino acid transporter genes in the human and mouse
RT genomes.";
RL Genomics 82:47-56(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15058382; DOI=10.1007/s00335-003-2319-3;
RA Bermingham J.R. Jr., Pennington J.;
RT "Organization and expression of the SLC36 cluster of amino acid transporter
RT genes.";
RL Mamm. Genome 15:114-125(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in testis.
CC {ECO:0000269|PubMed:12809675, ECO:0000269|PubMed:15058382}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AF453745; AAN76273.1; -; mRNA.
DR EMBL; AY211261; AAO37089.1; -; mRNA.
DR EMBL; AL713870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL772357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24708.1; -.
DR RefSeq; NP_758462.2; NM_172258.3.
DR RefSeq; XP_006532892.1; XM_006532829.3.
DR AlphaFoldDB; Q811P0; -.
DR STRING; 10090.ENSMUSP00000020502; -.
DR iPTMnet; Q811P0; -.
DR PhosphoSitePlus; Q811P0; -.
DR PaxDb; Q811P0; -.
DR PRIDE; Q811P0; -.
DR ProteomicsDB; 256890; -.
DR Antibodypedia; 28190; 50 antibodies from 14 providers.
DR DNASU; 215332; -.
DR Ensembl; ENSMUST00000020502; ENSMUSP00000020502; ENSMUSG00000049491.
DR GeneID; 215332; -.
DR KEGG; mmu:215332; -.
DR UCSC; uc007iyx.1; mouse.
DR CTD; 285641; -.
DR MGI; MGI:2665001; Slc36a3.
DR VEuPathDB; HostDB:ENSMUSG00000049491; -.
DR eggNOG; KOG1304; Eukaryota.
DR GeneTree; ENSGT00940000162406; -.
DR HOGENOM; CLU_009646_0_2_1; -.
DR InParanoid; Q811P0; -.
DR OMA; HAVWGRY; -.
DR OrthoDB; 464614at2759; -.
DR PhylomeDB; Q811P0; -.
DR TreeFam; TF314873; -.
DR BioGRID-ORCS; 215332; 2 hits in 38 CRISPR screens.
DR ChiTaRS; Slc36a3; mouse.
DR PRO; PR:Q811P0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q811P0; protein.
DR Bgee; ENSMUSG00000049491; Expressed in seminiferous tubule of testis and 10 other tissues.
DR ExpressionAtlas; Q811P0; baseline and differential.
DR Genevisible; Q811P0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005280; F:amino acid:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015193; F:L-proline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0015816; P:glycine transport; IBA:GO_Central.
DR GO; GO:0015808; P:L-alanine transport; IBA:GO_Central.
DR GO; GO:0035524; P:proline transmembrane transport; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..477
FT /note="Proton-coupled amino acid transporter 3"
FT /id="PRO_0000326205"
FT TOPO_DOM 1..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..399
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 454..477
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 19..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 46
FT /note="E -> K (in Ref. 1; AAN76273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 477 AA; 53068 MW; ADEAF848A9F88E3F CRC64;
MGNVPLLREV GKCQRNMFGR STASSKGSSN SRSSSSTSPK KGPRREADAL MFIQIFIHLL
KSNIGTGFLG LPLAVKNAGL LVGPVSLLAI GALTVHCMDI LLNCACHLTQ RLQRSFVNYE
ETTMYSLETC PSPWLRTHSV WGRYVVSFLL IVTQLGFCSV YFMFLADNLQ QIMEEAHFTS
NVCQPRQSLV MTSILDTRFY MLTILPFLIL LVLIQNPQVL SIFSTLATIT TLSSLALIFE
YLIQTPHHSN LPLVANWKTF LLFFGTAIFT FEGVGMVLPL KSQMKSPQQF PAVLYLGMSF
VIFLYICLGT LGYMKFGTDT QASITLNLPI CWLYQSVKLM YSVGIFFTYA LQFHVPAEII
VPYVVSRVSE NWALFVDLTV RTALVCLTCF SAVLIPRLDL VISLVGSVSS SALAIIIPPL
LEIATFYSEN ISCATIVKDI MISILGLLGC VLGTYQALYE MTQQTHFYMA NSTRVHI
