S36A3_RAT
ID S36A3_RAT Reviewed; 477 AA.
AC Q4V8B1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Proton-coupled amino acid transporter 3;
DE Short=Proton/amino acid transporter 3;
DE AltName: Full=Solute carrier family 36 member 3;
DE AltName: Full=Tramdorin-2;
GN Name=Slc36a3; Synonyms=Pat3, Tramd2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; BC097463; AAH97463.1; -; mRNA.
DR RefSeq; NP_001019935.1; NM_001024764.1.
DR RefSeq; XP_008765907.1; XM_008767685.2.
DR AlphaFoldDB; Q4V8B1; -.
DR SMR; Q4V8B1; -.
DR STRING; 10116.ENSRNOP00000037827; -.
DR PaxDb; Q4V8B1; -.
DR Ensembl; ENSRNOT00000037274; ENSRNOP00000037827; ENSRNOG00000021310.
DR GeneID; 303148; -.
DR KEGG; rno:303148; -.
DR UCSC; RGD:1309092; rat.
DR CTD; 285641; -.
DR RGD; 1309092; Slc36a3.
DR eggNOG; KOG1304; Eukaryota.
DR GeneTree; ENSGT00940000162406; -.
DR HOGENOM; CLU_009646_0_2_1; -.
DR InParanoid; Q4V8B1; -.
DR OMA; HAVWGRY; -.
DR OrthoDB; 464614at2759; -.
DR PhylomeDB; Q4V8B1; -.
DR TreeFam; TF314873; -.
DR PRO; PR:Q4V8B1; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000021310; Expressed in testis and 3 other tissues.
DR Genevisible; Q4V8B1; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005280; F:amino acid:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015187; F:glycine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015180; F:L-alanine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015193; F:L-proline transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0015816; P:glycine transport; IBA:GO_Central.
DR GO; GO:0015808; P:L-alanine transport; IBA:GO_Central.
DR GO; GO:0035524; P:proline transmembrane transport; IBA:GO_Central.
DR GO; GO:1902600; P:proton transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..477
FT /note="Proton-coupled amino acid transporter 3"
FT /id="PRO_0000326206"
FT TOPO_DOM 1..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..77
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..374
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..399
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..439
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..477
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 52850 MW; 62E8D79CB75452D0 CRC64;
MGKTPLLRED GRCQRNTFGG SKASSKGSSS SSSNNTVSSK KKPRRKADAL MFIQIFIHLL
KSNIGTGFLG LPLAVKNAGL LVGPVSLLAI GALTVHCMDI LLNCACHLTS RLQRSFVNYE
ETTMYSLETC PSPWLRTHSV WGRYVVSFLL IVTQLGFCSV YFMFMADNLQ QIVEEAHFTS
NVCQPRQSLV MTSILDTRFY MLTILPFLIL LVLVQNPQVL SIFSTLATIT TLSSLALIFE
YLIQIPHHSH LPLVASWKTF LLFFGTAIFT FEGVGMVLPL KSQMKSPQQF PAVLYLGMSF
VIFLYICLGT LGYMKFGADT QASITLNLPN CWLYQSVKLM YSVGIFFTYA LQFHVPAEII
VPYVVSRASE NWALFIDLTV RAALVCLTCF SAVLIPRLDL VISLVGSVSS SALALIIPPL
LEIATFYSEN ISCTTIAKDI MISILGLLGC VLGTYQALYE MTQQSRFPML NSTNVHT
