ID   S36A4_XENLA             Reviewed;         522 AA.
AC   Q4KL91; Q6DDP2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Proton-coupled amino acid transporter 4;
DE            Short=Proton/amino acid transporter 4;
DE   AltName: Full=Solute carrier family 36 member 4;
GN   Name=slc36a4; Synonyms=pat4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary, and Tadpole;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC077500; AAH77500.1; -; mRNA.
DR   EMBL; BC099353; AAH99353.1; -; mRNA.
DR   RefSeq; NP_001086438.1; NM_001092969.1.
DR   AlphaFoldDB; Q4KL91; -.
DR   SMR; Q4KL91; -.
DR   GeneID; 445866; -.
DR   KEGG; xla:445866; -.
DR   CTD; 445866; -.
DR   Xenbase; XB-GENE-994063; slc36a4.L.
DR   OMA; ALCYATF; -.
DR   OrthoDB; 697331at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 445866; Expressed in liver and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Glycoprotein; Membrane; Reference proteome; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..522
FT                   /note="Proton-coupled amino acid transporter 4"
FT                   /id="PRO_0000308320"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        467..487
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        515
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   522 AA;  58745 MW;  54238FB66837B450 CRC64;
     MDATELGVSG EGEEIDMEVM RPLIESEDRF EGTYGEKKHL QRYLNSDNKK DEEVMKPLIE
     NEDDSDGTCD EHQYLQRHPD LDNKDGLTFF QTLIHLLKGN IGTGLLGLPL AMKNAGVLLG
     PISLLFFGII SIHCMNILVR CSHFLCQRYK KANLGYSDTV GLALEVGPGV LQRHASFGRN
     LVDWFLVVTQ LGFCSVYFVF LAENIKQVFE VFLETKLQQS EIGIWSLDLR IYMFSFLPLI
     IPLVFIRDLK NLSLLSFFAN VSMAISLLIV YQYVIRNLSD PRTLPLGTSW KTYPLFFGTA
     IFAFEGIGVV LPLENRMRDK KDFSKALNIG MAIVTTLYIS LATLGYFCFG DQIKGSITLN
     LPQDSWLYQL VKILYSFGIY VTYAIQYYVP AEIILPAVTS RVQKTRKLLC EFTMRFFLVC
     LTCAVAVLIP RLDLVISFVG AVSSSTLALI LPPLVEIITY HKENLSPWVI MKDVGIAVIG
     FVGFIAGTYV TIEEMIYPIS YVPPNVSHSD FGVLNNTVLE GH