S38A2_XENTR
ID S38A2_XENTR Reviewed; 493 AA.
AC Q5XH90;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Sodium-coupled neutral amino acid transporter 2;
DE AltName: Full=Amino acid transporter A2;
DE AltName: Full=Solute carrier family 38 member 2;
DE AltName: Full=System A amino acid transporter 2;
DE AltName: Full=System A transporter 1;
DE AltName: Full=System N amino acid transporter 2;
GN Name=slc38a2; Synonyms=snat2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sodium-dependent amino acid transporter.
CC Mediates the saturable, pH-sensitive and electrogenic cotransport of
CC neutral amino acids and sodium ions with a stoichiometry of 1:1 (By
CC similarity). {ECO:0000250}.
CC -!- ACTIVITY REGULATION: Inhibited by N-methyl-D-glucamine and choline.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; BC084182; AAH84182.1; -; mRNA.
DR RefSeq; NP_001011056.1; NM_001011056.1.
DR AlphaFoldDB; Q5XH90; -.
DR SMR; Q5XH90; -.
DR PaxDb; Q5XH90; -.
DR DNASU; 496466; -.
DR GeneID; 496466; -.
DR KEGG; xtr:496466; -.
DR CTD; 54407; -.
DR Xenbase; XB-GENE-6258676; slc38a2.
DR eggNOG; KOG1305; Eukaryota.
DR InParanoid; Q5XH90; -.
DR OrthoDB; 1109791at2759; -.
DR Reactome; R-XTR-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-XTR-352230; Amino acid transport across the plasma membrane.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR GO; GO:0006868; P:glutamine transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Reference proteome; Sodium; Sodium transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..493
FT /note="Sodium-coupled neutral amino acid transporter 2"
FT /id="PRO_0000311375"
FT TOPO_DOM 1..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..357
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 379..400
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..423
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 445..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..493
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..92
FT /note="Regulates protein turnover upon amino acid
FT deprivation"
FT /evidence="ECO:0000250"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 241..268
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 493 AA; 54846 MW; 275386D0F423A217 CRC64;
MNNAEVLNVA LDEDSSNSND DLNYSEYQPK NHPIKSHYDM DIENVHFLLE PTMSKKKCET
EYLPGTTSFG MSVFNLSNAI VGSGILGLSY AMANTGIALF MILLVFVTVF SLYSIHLLLK
TANEGGSLLY EQLGLKAFGI PGKLAASGSV TLQNIGAMSS YLYIVKYELP LVIKALMDIK
ESNGEWYLNG DYLVIMVSLA IILPLSLLRN LGYLGYTSGF SPLCMVFFLI VVIYKKFEIP
CPLEAMNMTS NSSSHDHMAH NETDDEMCKP KYFVFNSQTV YAVPILTFSF VCHPAVLPIY
QELKGRSRRR MMNVSNVSFF AMFIMYLLAA LFGYLTFYSK VEPELLHTYS KVFGAGVIFV
VVRLAVLMAV TLTVPIVIFP IRSSLNELFC SGKDFAWIRH ILITFLILAF TNVLVIFVPT
IRDIFGFIGA SAAAMLVFIL PSAFYIRLVK KESMKSVQKI GALLFLIGGI IVMIGSMTLI
ILDWIHNSTS GGN
