S38A4_PONAB
ID S38A4_PONAB Reviewed; 547 AA.
AC Q5RE87;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Sodium-coupled neutral amino acid transporter 4;
DE AltName: Full=Amino acid transporter A3;
DE AltName: Full=Na(+)-coupled neutral amino acid transporter 4;
DE AltName: Full=Solute carrier family 38 member 4;
DE AltName: Full=System A amino acid transporter 3;
GN Name=SLC38A4; Synonyms=ATA3, SNAT4;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sodium-dependent amino acid transporter. Mediates
CC electrogenic symport of neutral amino acids and sodium ions. Has a
CC broad specificity, with a preference for Ala, followed by Ser, Gly,
CC Cys, Asn, Thr, Pro and Met. May mediate sodium-independent transport of
CC cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-
CC dependent, with highest transport activity between pH 7.5 and 8.5 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: The disulfide bond plays an important role in substrate transport,
CC but has no effect on trafficking to the cell surface. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; CR857647; CAH89920.1; -; mRNA.
DR RefSeq; NP_001129012.1; NM_001135540.1.
DR AlphaFoldDB; Q5RE87; -.
DR SMR; Q5RE87; -.
DR STRING; 9601.ENSPPYP00000005067; -.
DR GeneID; 100190852; -.
DR KEGG; pon:100190852; -.
DR CTD; 55089; -.
DR eggNOG; KOG1305; Eukaryota.
DR InParanoid; Q5RE87; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 2.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Cell membrane; Disulfide bond; Glycoprotein;
KW Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..547
FT /note="Sodium-coupled neutral amino acid transporter 4"
FT /id="PRO_0000247862"
FT TOPO_DOM 1..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..220
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..332
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 354..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 391..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..476
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 498..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 536..547
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9EQ25"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 249..321
FT /evidence="ECO:0000250"
SQ SEQUENCE 547 AA; 60681 MW; FF08445DCF50FDF7 CRC64;
MDPMELRNVN IEPDDESSSG ESVPDSYIGI GNSEKAAMSS QFANEDAESQ KFLTNGFLGK
KKLADYGDEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM ANTGIILFII MLLAVAILSL
YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG KIGAFISITM QNIGAMSSYL FIIKYELPEV
IRAFMGLEEN TGEWYPNGNY LIVFVSLGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV
IYKKFQIPCP LPVLDHSVGN LSFNNTLSMH VVMLPNNSES SDVNFMMDYT HRNPAGLDEN
KAKGSLHDSG VEYEAHSDDK CQPKYFVFNS RTAYAIPILA FAFVCHPEVL PIYSELKDRS
RRKMQTVSNI SITGMLVMYL LAALFGYLTF YGEVEDELLH AYSKVYTFDI PLLMVRLAVL
VAVTLTVPIV LFPIRTSVTT LLFPKRPFSW IRHFLIAAVL IALNNVLVIL VPTIKYIFGF
IGASSATMLI FILPAVFYLK LVKKESFRSP QKVGALIFLV VGIIFMIGSM ALIIIDWIYD
PPNSKHH
